International Collaborative Research Program for Tackling the NTDs (Neglected Tropical Diseases) Challenges in African countries

This program will be implemented at universities and other research institutes both in Japan and African countries to achieve the goal of controlling NTDs. The program covers research and development in the medical and public hygiene fields, including from basic research to the establishment of methods for diagnosis, surveillance, prevention, drug discovery and treatment. It also includes research on proposing policies and operations, such as a public-hygiene system to control NTDs, based on the results of the aforementioned research and development. During these activities, through close cooperation at local sites, centers for international joint research and cooperative activities will be established to help local researchers continue and extend their efforts over a long period. These centers are also expected to provide training and education to prospective young African researchers with the aim of contributing to innovation in Africa.

Seventeen infectious diseases* designated by the World Health Organization as neglected tropical diseases (NTDs), which must be controlled by humankind.

* Buruli ulcer, Chagas disease, Cysticercosis, Dengue, Dracunculiasis (guinea-worm disease), Echinococcosis, Endemic treponematoses (Yaws), Foodborne trematodiases, Human African trypanosomiasis (sleeping sickness), Leishmaniases, Leprosy (Hansen disease), Lymphatic filariasis, Onchocerciasis (river blindness), Rabies, Schistosomiasis, Soil-transmitted helminthiases, Trachoma causing blindness

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Implementing Body

Title of Research and Development Establishment of the model for controlling neglected tropical diseases based on the development of rapid diagnostic methods and risk analysis
Representative institutions Hokkaido University
Principal Investigator Yasuhiko Suzuki
Foreign representative institutions(Country) The University of Zambia (Republic of Zambia)
Summary of research and development

To control neglected tropical diseases in African continent, we will try to complete following items targeting leprosy and human African trypanosomiasis (HAT) as model diseases.

  1. To grasp the actual situation of leprosy and HAT in Zambia
  2. To develop rapid diagnostic methods for leprosy and HAT and implement them at field sites in Zambia
  3. To establish the control measure packages of leprosy and HAT and provide them to Zambia
Title of Research and Development Integrated research program for the control of dengue fever mosquito in Burkina Faso, West Africa
Foreign representative institutions The Jikei University School of Medicine
Principal Investigator Hirotaka Kanuka
Foreign representative institutions(Country) Université de Ouagadougou (Burkina Faso)
Summary of research and development Integrated vector management (IVM) is defined as a rational decision-making process for the optimal use of resources for vector control. Its aim is to improve the efficacy, cost-effectiveness, ecological soundness and sustainability of disease vector control. The framework in our proposal focuses particularly on four key elements for a holistic IVM strategy in Burkina Faso: a) development of rapid diagnosis methods for pathogen and its vector, b) vector surveillance with systematic monitoring of the seasonality and abundance of vector population, c) understanding mechanism related to vector competency and its control by microbe-based paratransgenesis, and d) neuro-ethological analysis of vector behavior in particular host sensing and blood-feeding. These IVM strategies are additional to, and compatible with, conventional measures (such as use of bed nets) and medicinal therapies. Several small research teams (“mobile-unit”) consisting of faculty members, postdocs, graduate students, and/or technicians will be involved in each study element.
Title of Research and Development An innovative continent-wide NTD surveillance network based on simultaneous multiplex assay technology in Africa
Representative institutions Nagasaki University
Principal Investigator Satoshi Kaneko
Foreign representative institutions(Country) Kenya Medical Research Institute (Republic of Kenya)
Summary of research and development

This program intends to develop a continent wide NTD surveillance network based on a multiple assay system. During the research period, it will achieve the following objectives:

  1. Development and Optimization of a multiple assay system based on regional characteristics of NTD infections
  2. Development and evaluation of an implementable NTD surveillance system in Africa
  3. Development of a multiplex assay network, human resources capacity development and information sharing related to NTD surveillance
  4. Sharing of information on NTD’s and NTD surveillance in Africa
  5. Design of an NTD information dissemination platform for the international community.

Results Report

Management Framework

PS(Program Supervisor)

PO(Program Officer)

Reference

Brochure

Contact

Division of International Collaboration, Department of International Affairs
Tel : +81-3-6870-2216
Email : africa-ntds”at”amed.go.jp

※Replace”at”with @.

Last updated 2017.5.18

Research Integrity