Division of Emerging Research Advanced Research & Development Programs for Medical Innovation(AMED-CREST, PRIME)

Elucidation of Mechanobiological Mechanisms and Their Application to the Development of Innovative Medical Instruments and Technologies

[Research and Development Objective] Elucidation of Mechanobiological Mechanisms Leading to the Development of Innovative Medical Instruments and Technologies

Outline of the Research & Development (R&D) Area

The main objective of the R&D area is to elucidate the mechanisms by which cells and tissues sense, transduce, and respond to physical stimulations and to utilize such mechanobiologic knowledge to develop new fundamental technologies that will lead to medical applications.

In recent years it has become apparent that cells in a human body are exposed to a variety of physical forces created by the motion of skeletal muscles and organs and by blood stream, gravity, and neighboring cells (including mechanical forces created by the microenviroment around cells), and that the cells utilize such physical stimulations to control their own growth, differentiation, proliferation, death, morphogenesis, migration, etc. However, the precise molecular mechanisms remain unclear by which cells sense physical stimulations and convert them into intracellular biochemical signals and their ultimate physiological or pathological responses. In order to clarify the roles of physical stimulations in the structure and function of cells, tissues, organs, and organisms, mechanobiology has come into being as a new research field based on physics, engineering, biology, and medicine.

Elucidation of the mechanisms by which organisms sense and respond to physical stimulations has the potential to lead to breakthroughs in the effort to solve various biological and medical problems, e.g. problems concerning ordered formation of tissues during the growth and development of individuals and wound healing, and regenerative medicine. Moreover, by utilizing Japan’s state of the art technologies such as bio-nano surface technology and MEMS (micro-electro-mechanical systems), it should become possible to develop new devices, e.g., devices capable of quantitatively applying and controlling physical stimulations and apparatus capable of precisely measuring biological reactions to physical stimulations.

The aim of the R&D area is to promote mechanobiology research and develop basic techniques that will lead to innovative medical instruments and technologies so as to contribute the achievement of a society in which people are healthy and live a long life.

Year the Area adopted


Management and Evaluation Framework

Program Supervisor (PS)

Masahiro Sokabe
Professor, Mechanobiology Laboratory, Nagoya University Graduate School of Medicine

Program Officer (PO)

Joji Ando
Professor, Laboratory of Biomedical Engineering, School of Medicine, Dokkyo Medical University

R&D Area Advisors

Yoshihito Osada
Senior Visiting Scientist, RIKEN
Hidetoshi Kotera
Executive Director, RIKEN
Masaaki Sato
Executive Adviser, Tohoku University, Frontier Research Institute for Interdisciplinary Sciences
Takashi Shigematsu
Quality Assurance & Regulatory Affairs Department, OLYMPUS TERUMO BIOMATERIALS CORP.
Shinichi Takeda
Exective director, National Center of Neurology and Psychiatry
Keiji Naruse
Professor, Okayama University
Takahiro Nishimoto
Deputy General Manager, Technology Research Laboratory, Shimadzu Corporation
Kazue Mizumura
Professor Emeritus, Nagoya University


Last updated 2019.1.31