Division of Basic Medical Research FY2023 List of Projects - Research Program on Hepatitis

Program for Basic and Clinical Research on Hepatitis

First Year	Principal Investigator	Affiliation		Project Title
FY2021	HIASA Yoichi	Ehime University	Professor	Development of immune therapy to achieve drug-free for the patient with chronic hepatitis B
FY2021	SUZUKI Fumitaka	Toranomon Hospital	Director	The analyses of factors associated with drug free status and try to establish the therapies for setting out to drug free status and HBsAg
FY2021	YOSHIZUMI Tomoharu	Kyushu University	Professor	Development of cost-effective prophylaxis and treatment for hepatitis B virus (HBV) reactivation
FY2021	SUZUKI Tetsuro	Hamamatsu University School of Medicine	Professor	Development of a novel class of anti-HCV agents targeting the viral NS2
FY2021	SAKAI Katsuya	Kanazawa University	Associate Professor	A versatile hepatitis treatment based on recovery from liver dysfunctions and fibrosis achieved by an engineered
FY2021	MIZUGUCHI Hiroyuki	Osaka University	Professor	Development of hepatic tissue derived organoids for the novel treatment of cirrhosis and liver failure
FY2021	KANEYAMA Shuri	Showa University School of Medicine	Associate Professor	Development of the antisense nucleic acid aiming to treat liver fibrosis via extracellular matrix remodeling
FY2021	KOIKE Kazuhiko	The University of Tokyo	Professor Emeritus	Study of pathogenesis of metabolism-associated liver cancer on the background of steatohepatitis
FY2021	KANTO Tatsuya	National Center for Global Health and Medicine	Director General	Development of medicine for NASH patients with liver cancer based on inflammaging lipid-genomics research 2.0
FY2021	OTSUKA Motoyuki	Okayama University	Professor	Elucidation of the mechanisms of chronic inflammation-induced hepatocarcinogenesis and development of novel
FY2021	NAKATSURA Tetsuya	National Cancer Center	Chief	Development of technology to suppress the onset and recurrence of liver cancer with circulating tumor cells and personalized immunotherapy
FY2021	YOSHIO Sachiyo	National Center for Global Health and Medicine	Chief	Development of novel therapy for the patients with chronic liver disease based on comprehensive understanding of muscle-liver-metabolism axis and immune system
FY2021	YAMASHITA Taro	Kanazawa University	Professor	Development of a novel synthetic ligand optimized for the activation of hepatocyte nuclear factor 4α, a master regulator of liver metabolism, regeneration, and carcinogenesis, to develop an innovative treatment strategy on liver cancer
FY2021	NAKAMOTO Nobuhiro	Keio University	Associate Professor	Study to elucidate the mechanism of liver fibrosis and resolution via inter-organ network
FY2021	YOSHIJI Hitoshi	Nara Medical University	Professor	Development research of novel pathophysiology and therapy for hepatorenal syndrome in cirrhosis -Thrombotic microangiopathy and recombinant ADAMTS13 therapy-
FY2021	SHIOZAWA Yusuke	Nippon Medical School	Assistant Professor	Specific excision of hepatitis B virus covalently closed circular DNA using Cas9 nickase
FY2021	MATSUMOTO Tomonori	Osaka University	Assistant Professor	Exploration of novel treatment strategies for drug resistance and emergence of liver cancers targeting ploidy alterations and senescence escape
FY2021	Xian Yang QIN	RIKEN	Research Scientist	Molecular pathology and drug discovery of liver cancer by tracing dynamic changes of cancer stem cell marker expression
FY2022	MIZUKOSHI Eishiro	Kanazawa University	Associate Professor	Study to prevent liver carcinogenesis after treatment for chronic hepatitis C
FY2022	TANAKA Shinji	Tokyo Medical and Dental University	Professor	Subtype-specific prevention and treatment for occurrence and recurrence of post-SVR hepatocellular carcinoma
FY2022	TANAKA Yasuhito	Kumamoto University	Professor	Elucidation of disease progression including liver carcinogenesis after hepatitis C virus eradication and establishment of preventive method
FY2022	ENOMOTO Nobuyuki	University of Yamanashi	Professor	Study on the mechanism of hepatocellular carcinoma development and pathological changes after hepatitis C virus elimination using next generation sequencing technology
FY2022	INAGAKI Yutaka	Tokai University	Professor	Development of novel anti fibrotic therapy based on deactivation of collagen producing cells and original in silico drug design
FY2022	ASAHINA Yasuhiro	Tokyo Medical and Dental University	Professor	Elucidation of mechanisms for liver fibrogenesis and hepatocarcinogenesis using innovative organoid technology and creation of breakthrough anti fibrogenic/carcinogenic treatments
FY2022	KAWADA Norifumi	Osaka Metropolitan University	Professor	Molecular understanding and therapy development of liver cirrhosis based on bioinformatics analysis of genes associated with hepatic microvascular cell-derived secretome
FY2022	OHDAN Hideki	Hiroshima University	Professor	Research and development of novel hepatitis and hepatocellular carcinoma treatment by immunotherapy using differentiation-regulated NK cells
FY2022	SUZUKI Ryosuke	National Institute of Infectious Diseases	Chief	Basic research to control the propagation and pathogenicity of hepatitis viruses
FY2022	OKAMOTO Toru	Juntendo University	Professor	Elucidating pathogenesis of hepatitis viruses for drug discovery
FY2022	TOKUNAGA Katsushi	National Center for Global Health and Medicine	Director	Clinical genome analysis for personalized management of hepatitis B and practical usage of data storage (KANEN-DS)
FY2022	MURATA Kazumoto	Jichi Medical University	Professor	Study of therapeutic strategies and drug discovery for HBsAg reduction in HBV infection, based on immunomodulatory effects of nucleotide analogs
FY2022	TAKEHARA Tetsuo	Osaka University	Professor	Study of elucidating the impact of interferon free treatment on the outcomes, including prognosis, in patients with cirrhosis C
FY2022	KAKAZU Eiji	National Center for Global Health and Medicine	Chief	Study of mitochondria and communication among organ systems in MAFLD
FY2022	NAKAGAWA Hayato	Mie University	Professor	AFP revisited: Development of new therapeutic strategies to promote liver regeneration and prevent carcinogenesis
FY2022	SUZUKI Atsushi	Kyushu University	Professor	The study for developing a method to treat the hepatic cirrhosis using induced hepatic progenitor cells and their secretory component
FY2022	WADA Haruka	Hokkaido University	Associate Professor	Research and development of macrophage therapy for liver cirrhosis aiming an investigator-initiated clinical trial
FY2022	MIYOSHI Masato	Tokyo Medical and Dental University	Assistant Professor	Analysis of molecular mechanisms underlying the initial phase of activation of hepatic stellate cells using an original culture method
FY2022	ARIMA Yuichiro	Kumamoto University	Associate Professor	Development of non-alcoholic fatty liver disease treatment method through ketone body metabolism
FY2022	WAKAE Kousho	National Institute of Infectious Diseases	Chief Investigator	Development of a novel relapse marker of hepatocellular carcinoma, based on the amount of human-HBV chimeric DNA
FY2023	TAKEHARA Tetsuo	Osaka University	Professor	Elucidation of long-term course after hepatitis C virus elimination and　pathogenesis of Post-SVR hepatopathy
FY2023	CHAYAMA Kazuaki	Hiroshima University	Professor	Study of prognostic factors affecting life
FY2023	KUROSAKI Masayuki	Musashino Red Cross Hospital	Vice President	Study of changes in clinical course of viral hepatitis caused by drug resistance and its treatment
FY2023	TAJIRI Hitoshi	Wakayama Medical University	Postdoctoral Researcher	Studies on the clinical courses and impact of treatment for viral hepatitis during childhood and on development of treatment strategy
FY2023	UMEMURA Takeji	Shinshu University	Professor	Development of novel therapy for liver fibrosis, elucidation of mechanisms, and establishment of evaluation methods
FY2023	SAKAMOTO Naoya	Hokkaido University	Professor	Study on novel glycobiomarkers for non-invasive assessment of liver fibrosis
FY2023	TERAI Shuji	Niigata University	Professor	Establishment of Rehabilitation Medicine for Muscle Regeneration in Cirrhosis of the Liver – An Exploratory Study of New Biomarkers through the Analysis of Liver Repair Mechanisms
FY2023	NAKAYA Michio	Kyushu University	Associate Professor	Creation of a novel liver fibrosis treatment and a minimally invasive specifically expressed in activated hepatic stellate cells
FY2023	KODAMA Takahiro	Osaka university	Assistant Professor	Study of the pathogenesis of NAFLD/NASH and non-viral liver cancer and development of therapeutics
FY2023	NAKAGAWA Hayato	Mie University	Professor	Development of “next-generation precision medicine” for NAFLD
FY2023	HONDA Masao	Kanazawa University	Professor	Revealing the association of impaired barrier function of liver sinusoidal endothelial cells and the onset of non alcoholic steatohepatitis and hepatocellular carcinoma
FY2023	KANDA Tatsuo	Nihon University School of Medicine	Associate Professor	Study of Prevention, Pathological Development and Treatment for Hepatitis A and E Virus Infection
FY2023	UENO Hideki	Kyoto University	Professor	Development of a novel liver-immune organoid model and its application for the establishment of methods to achieve HBV functional cure via HBs Ab induction
FY2023	OTSUKA Motoyuki	Okayama University	Professor	Development of new regulatory methods based on the elucidation of HBV pathogenesis through focusing on RNAs
FY2023	SUGIYAMA Masaya	National Center for Global Health and Medicine	Director (Tenure track)	Research on elucidating the microenvironment of hepatitis B pathogenesis and developing new treatment modalities, using cutting-edge technology
FY2023	TANAKA Shinji	Tokyo Medical and Dental University	Professor	Development of prevention and treatment of immuno-resistant subtypes in hepatocellular carcinoma with chronic hepatitis
FY2023	NISHIDA Nao	Tokyo Medical and Dental University	Associate Professor	Study to elucidate mechanism of HBV related liver carcinogenesis by deep spatial omics analysis
FY2023	HIKITA Hayato	Osaka University	Associate Professor	Study for elucidating the effects and mechanisms of sinusoidal hypertension in liver cirrhosis on the progression of liver pathology
FY2023	NAKANO Yasuhiro	Kanazawa University	Assistant Professor	Identification of Novel Therapeutic Target Molecules by Single-Cell Resolution Analysis of Senescent Cells in Nonalcoholic Steatohepatitis
FY2023	MURAI Kazuhisa	Kanazawa University	Assistant Professor	Elucidation of the immunosuppressive mechanism in liver cancer based on the understanding of cancer cell metabolism
FY2023	YAMAGISHI Ryota	Osaka Metropolitan University	Assistant professor	Elucidation of the molecular mechanism of hepatocellular carcinoma suppression by exercise: toward identification of the exercise-mimicking molecules for prevention and treatment of cancer

Program on the Innovative Development and the Application of New Drugs for Hepatitis B

First Year	Principal Investigator	Affiliation		Project Title
FY2022	SAKAMOTO Naoya	Hokkaido University	Professor	High-throughput screening of antiviral seed compounds by using HBV cell culture and antiviral response reporter models
FY2022	ITO Kiyoaki	Aichi Medical University	Professor	Development of novel antiviral agents that enable HBV elimination by inhibiting infection of uninfected hepatocytes
FY2022	KATO Takanobu	National Institute of Infectious Diseases	Chief	Study of viral and host factors for the production and maintenance of hepatitis B virus cccDNA
FY2022	WATASHI Koichi	National Institute of Infectious Diseases	Director, Division of Drug Development	Regulation of hepatitis B virus infection by the receptor cofactor and its application to drug development
FY2022	UEDA Keiji	Osaka University Graduate School of Medicine	Professor	Study of host-virus interaction to develop anti-HBV strategy
FY2022	MORIISHI Kohji	Graduate Faculty of Interdisciplinary Research, University of Yamanashi	Professor	Study contributing to the elucidation of the mechanism of genomic activation and replication of hepatitis B virus and the identification of antivirals and host targets
FY2022	SHOJI Ikuo	Kobe University Graduate School of Medicine	Professor	Study of hepatitis B virus propagation and drug discovery research using the reporter HBV system
FY2022	NISHINA Hiroshi	Tokyo Medical and Dental University	Professor	Study of host elimination mechanism of HBV-infected hepatocytes and identification of drug target
FY2022	MIZUKOSHI Eishiro	Kanazawa University	Associate Professor	Study of elucidation of host defense mechanisms against hepatitis B virus and development of immunotherapy
FY2022	FUJITA Takashi	Kyoto University	Visiting Professor	Studies on replication mechanism of HBV and development of novel therapy for HBV infection: novel HBV infection mouse model and screening for cccDNA inhibitors
FY2022	AIZAKI Hideki	National Institute of Infectious Disease	Chief	Elucidation of pathology and development of new treatment methods using hepatitis B virus persistent infection model
FY2022	TAKEHARA Tetsuo	Osaka University	Professor	Elucidation of the pathogenesis and development of new treatment using persistent hepatitis B virus infection models
FY2022	CHAYAMA Kazuaki	Hiroshima University	Professor	Development of curative therapy of chronic hepatitis B virus infection using persistent hepatitis B mouse model
FY2022	HONDA Masao	Kanazawa University	Professor	Study of the optimization of new therapies for the removal of HBV and the establishment of theoretical backgrounds
FY2022	MIZOKAMI Masashi	National Center for Global Health and Medicine	Project Leader	Comprehensive research towards the practical application of genome-editing therapy to eliminate the hepatitis B virus
FY2022	KANTO Tatsuya	National Center for Global Health and Medicine	Director General	Development of therapy against chronic hepatitis B with an orallyavailable TLR-7 agonist, SA-5, and establishment of the system for an investigator-initiated FIH study
FY2022	MURAMATSU Masamichi	Foundation for Biomedical Research and Innovation at Kobe	Director	Research and development of anti-HBV therapy and diagnostic drugs
FY2022	TANAKA Yasuhito	Kumamoto University	Professor	Development of new hepatitis B therapeutic agents for clinical application
FY2022	ISOGAWA Masanori	National Institute of Infectious Diseases	Chief	Study for developing novel immunotherapies to achieve functional cure of chronic hepatitis B
FY2022	SUGIYAMA Masaya	National Center for Global Health and Medicine	Director (Tenure track)	Elucidation of hepatitis B virus (HBV) POL function and development of new drugs on the basis of technology for full-length HBV-POL expression
FY2022	SAWASAKI Tatsuya	Ehime University	Professor	Study of development of AI-designed Hepatitis B virus polymerase and its inhibitors
FY2022	FUJIMOTO Akihiro	The University of Tokyo	Professor	Comprehensive analysis of full-length transcripts in hepatitis and liver cancer tissues
FY2022	FUKUHARA Takasuke	Hokkaido University	Professor	Development of genome-editing drugs of adenovirus vector expressing eight multiplex guide RNAs using models of HBV replication in humanized mice and of HBV carcinomas
FY2022	TAKETOMI Akinobu	Hokkaido University	Professor	Study of the clinical significance of previous infection with HBV in HCC and the molecular mechanism of hepatocarcinogenesis in HBc antibody positive patients

Last updated 04/24/23