Division of Basic Medical Research FY2020 List of Projects - Research Program on Hepatitis

Program for Basic and Clinical Research on Hepatitis

First Year Principal Investigator Affiliation Project Title
FY2018 HIASA Yoichi Ehime University Professor Establishment of clinical immunotherapy against hepatitis B virus to stop the administration of nucleotide analogue
FY2018 MURATA Kazumoto Jichi Medical University Professor Investigation for new therapeutic strategies and drug-discovery for withdrawal of drugs in HBV infection, based on novel cytokines’ production  by nucleotide analogues
FY2018 MIZOKAMI Masashi National Center for Global Health and Medicine Project Leader Development of cost-effective prevention protocols and elucidation of the mechanism for hepatitis B reactivation
FY2018 WATASHI Koichi National Institute of Infectious Diseases Senior Researcher Nuclear hormone receptor ligands for controlling difficult-to-treat hepatitis C and steatohepatitis
FY2018 TAKEBE Takanori Tokyo Medical and Dental University Professor Development of human NAFLD organoid panel for innovative drug screening
FY2018 UMEZAWA Akihiro National Center for Child Health and Development Director Development of novel embryonic stem cell-based products for liver cirrhosis and liver failure
FY2018 INAGAKI Yutaka Tokai University Professor Novel Diagnostic and Treatment Strategies for Regeneration of Fibrotic Liver by Focusing on an Exosome-carrying Regenerating Factor
FY2018 KOIKE Kazuhiko The University of Tokyo Professor Study on the pathogenesis of metabolism-associated liver cancer including those associated with viral hepatitis
FY2018 KANTO Tatsuya National Center for Global Health and Medicine Director General Development of tailored medicine for NASH patients with liver cancer based on lipidgenomics research
FY2018 NISHINA Hiroshi Tokyo Medical and Dental University Professor Study of an innovative HBV-related liver disease therapy based on abnormal hepatocyte elimination
FY2018 TOITA Riki National Institute of Advanced Industrial Science and Technology Researcher Development of inflammatory immune cell-targeted nanomedicine for the prevention and treatment of NASH/NAFLD
FY2018 YOSHIO Sachiyo National Center for Global Health and Medicine Chief Development of novel therapy for the patients with cirrhosis based on immunological analysis targeting muscle-liver axis
FY2018 SHIRASAKI Takayoshi Kanazawa University Assistant Professor Studies on a novel immune control mechanism against liver diseases
FY2019 ENOMOTO Nobuyuki University of Yamanashi Professor Study on  factors influencing post treatment pathological status in hepatitis C patients receiving direct acting antiviral agents using next generation sequencing technology
FY2019 TANAKA Yasuhito Nagoya City University Professor Genome-wide research aimed at identifying host factors affecting the changes in disease conditions after direct acting antiviral therapies for hepatitis C
FY2019 KANEKO Shuichi Kanazawa University Professor Study of preventing hepatocarcinogenesis from chronic hepatitis C
FY2019 KAWADA Norifumi Osaka City University Professor Study on the development of regression therapy for liver fibrosis by using recombinant human Cytoglobin
FY2019 OHDAN Hideki Hiroshima University Professor Research and development of immune-therapy using pluripotent stem cells as potential anti-hepatitis/hepatoma therapeutics
FY2019 KATO Naoya Chiba University Professor Development of Hepatocarcinogenesis Prevention in Hepatitis C by Activating Innate Immune Response
FY2019 MURAMATSU Masamichi National Institute of Infectious Diseases Director Basic research and development of novel diagnostic and therapeutic approaches for viral hepatitis
FY2019 OTSUKA Motoyuki The University of Tokyo

Lecturer

Development of novel interventional methods against hepatitis B based on the comprehensive elucidation of its pathogenesis
FY2019 OKAMOTO Toru Osaka University Professor Development of novel therapeutics for pathogenesis induced by hepatitis viruses
FY2019 TOKUNAGA Katsushi National Center for Global Health and Medicine Co-Director, Genome Medical Science Project Study for clinical sequencing based on genome analysis of host and viral factors
FY2019 YAMAMOTO Takuya National Institutes of Biomedical Innovation, Health and Nutrition Project Leader Establishment of therapeutic strategies toward a functional cure for HBV by innovative immunotherapies
FY2019 TAKEHARA Tetsuo Osaka University Professor Study of outcome of liver cirrhotic patients received HCV elimination therapy
FY2019 NAKAGAWA Hayato The University of Tokyo Specially Appointed Lecturer Relevance of burned-out phenomenon to the pathogenesis of NASH: Development of a new therapeutic strategy based on lipid metabolism
FY2019 ASAHINA Yasuhiro Tokyo Medical and Dental University Professor Development of an innovative disease model using human iPS cell-derived liver organoids and creation of treatments to suppress hepatic fibrosis and hepatocarcinogenesis
FY2019 SUGIYAMA Masaya National Center for Global Health and Medicine Vice Director Development of full-length HBV-POL expression system for drug discovery
FY2019 YAMANE Daisuke Tokyo Metropolitan Institute of Medical Science Chief Researcher Study of Intrinsic Antiviral Signaling Pathways in Hepatocytes Toward the Development of Novel Antiviral Strategies
FY2019 TAKAYAMA Kazuo Kyoto University Junior Assistant Professor Functional analysis and regulation of liver disease-associated gene TLL1
FY2020 TAKEHARA Tetsuo Osaka University Professor Elucidation of the progression of liver pathology such as liver carcinogenesis after hepatitis C virus elimination and its predictors
FY2020 CHAYAMA Kazuaki Hiroshima University Professor Study of factors associated with health status and prognosis after successful HCV
eradication
FY2020 AIZAKI Hideki National Institute of Infectious Disease Chief Study on pathology and course of liver carcinogenesis after sustained virologic response in hepatitis C
FY2020 KUROSAKI Masayuki Musashino Red Cross Hospital Vice President Study on the effect of resistance associated substitutions on clinical features of hepatitis C virus infection
FY2020 TAJIRI Hitoshi Kindai University Nara Hospital Researcher Studies on evaluation of progression of viral hepatitis during childhood and on development of treatment strategy
FY2020 YATSUHASHI Hiroshi National Hospital Organization Nagasaki Medical Center Vice President Study of contributing to improvement of QOL and improvement of prognosis in patients with liver cirrhosis
FY2020 TERAI Shuji Niigata University Professor Translational research aiming for development of next generation exosome therapy for cirrhosis
FY2020 OSAFUNE Kenji Kyoto University Professor Development of cell therapy against liver cirrhosis using human iPS cells and nonhuman primate liver disease models
FY2020 SAKAMOTO Naoya Hokkaido University Professor Screening of prognostic biomarker by comprehensive serum and liver tissue glycomics
FY2020 HONDA Masao Kanazawa University Professor Revealing the association of impaired barrier function of liver sinusoidal endothelial cells and the onset of lifestyle disease related non-B, non-C hepatitis and hepatocellular carcinoma
FY2020 KODAMA Takahiro Osaka university Assistant professor Study of molecular mechanisms of NASH and non-B non-C liver cancer and exploration of their therapeutic targets
FY2020 KANDA Tatsuo Nihon University School of Medicine Associate Professor Research and development of infection prevention, pathological mechanism, diagnosis and treatment for hepatitis A and E viruses
FY2020 UENO Hideki Kyoto University Professor Promoting HBs seroconversion in chronic HBV infection
FY2020 NAKAMOTO Yasunari University of Fukui Professor Development of Novel Targeted Immunotherapy for Chronic Hepatitis B to Regulate both Virus and Carcinogenesis
FY2020 NISHIDA Nao National Center for Global Health and Medicine Senior Researcher Predictive Model to Prevent Development of Liver Disease Based on the Polygenic Risk Score (PRS)
FY2020 MIYOSHI Eiji Osaka University Graduate School of Medicine Professor Study of novel hepatocarcinogenesis mechanism using glycotechnology and its application
FY2020 SEKIBA Kazuma The University of Tokyo Staff Doctor Comprehensive identification of host factors maintaining HBV cccDNA by CRISPR technology for the development of new therapeutic methods
FY2020 MURAI Kazuhisa Kanazawa University Assistant Professor Establishment of the research infrastructure for liver cancer microenvironment and exploratory research of a novel cancer immunotherapeutic target
FY2020 ABE Yuichi Aichi Cancer Center Research Institute Senior Scientist Screening of novel diagnostic markers and therapeutic targets for NASH-derived hepatocellular carcinoma by ultra-sensitive multi-omics

Program on the Innovative Development and the Application of New Drugs for Hepatitis B

 
First Year Principal Investigator Affiliation Project Title
FY2017 TANAKA Yasuhito Nagoya City University Professor Drug screening for developing HBV therapeutics and optimization of the hit compounds
FY2017 MORIYA Kyoji The University of Tokyo Professor Search for drug candidates with novel mechanisms capable of efficient inhibition of hepatitis B virus propagation
FY2017 MURAMATSU Masamichi National Institute for Infectious Diseases Director Basic research on hepatitis B virus life cycle and anti-viral development
FY2017 KATSUJI Kunio Kobe University Professor Analysis of HBV life cycle by using sophisticated reporter HBV systems and its application to the development of a new strategy to suppress HBV infection and replication
FY2017 UEDA Keiji Osaka University Professor Exploitation of anti-HBV strategies by targeting cellular factors functioning in the HBV life cycle
FY2017 KANTO Tatsuya National Center for Global Health and Medicine Director General Establishment of novel therapeutic strategies against HBV - An integrated Immuno-omics approach
FY2017 FUJITA Takashi Kyoto University Visiting Professor Research for HBV therapy development based on the establishment of HBV-sensitive cell and animal models
FY2017 TAKEHARA Tetsuo Osaka University Professor Development of molecular pathogenesis and drug discovery using HBV infection models
FY2017 CHAYAMA Kazuaki Hiroshima University Professor Hepatitis B virus eradication therapy development using a highly efficient cell culture system and a long term active chronic hepatitis B mouse model
FY2017 KANEKO Shuichi Kanazawa University Professor Development of new antiviral therapies for hepatitis B virus
FY2017 MIZOKAMI Masashi National Center for Global Health and Medicine Project Leader Comprehensive development of innovative therapeutic methods for complete inactivation of the HBV genome in the liver through application of genome-editing technology in personalized medicine
FY2017 MATSUURA Tomokazu RIKEN Visiting Senior Researcher Drug discovery researches for licensing-out the next generation anti-HBV drugs
FY2017 MITSUYA Hiroaki Kumamoto University Distinguished Guest Professor Development of novel anti-hepatitis B virus (HBV) agents potent against wild-type- and drug-resistant-HBVs
FY2017 WATASHI Koichi National Institute of Infectious Diseases Senior Researcher Drug development against hepatitis B virus using chemical biological approaches and mathematical models
FY2017 ITO Kiyoaki Aichi Medical University Professor Regulation of hepatitis B virus targeting by the control mechanisms of bile acid metabolism

Last updated 05/25/21