Department of Basic Medical Research Interdisciplinary Cutting-edge Research
Outline
The Interdisciplinary Cutting-edge Research program supports basic research on the control of emerging and reemerging infectious diseases that integrates multiple disciplines and is conducted by researchers and clinicians in diverse fields. This will enable new concepts to be established for prevention, diagnosis, and treatment based on the understanding of the pathogenesis of infectious diseases.
To support a wide range of novel basic research that will contribute to countermeasures against infectious diseases from a long-term perspective, funded research projects involve researchers and clinicians from diverse fields to discover new perspectives and create innovative results using the latest technologies.
Ongoing Research Projects
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Study of brain organoids and mouse models for the therapeutic application of paramyxovirus central nervous system infection | HASHIGUCHI Takao | Kyoto University, Professor |
| Elucidation of the mechanisms of multiple organ failure in the streptococcal toxic shock syndrome, and the investigation of novel therapeutic strategies | HIROSE Yujiro | Osaka University, Assistant Professor |
| Beyond CRISPR: Development of Antimicrobials using Defens Systems | KIGA Kotaro | National Institute of Infectious Diseases, Group leader |
| Study for elucidation of the onset mechanism of infant botulism | KOBAYASHI Nobuhide | Kanazawa University, Assistant Professor |
| Design of modified T cell antigens inducing potent antiviral activity | MOTOZONO Chihiro | Kumamoto University, Lecturer |
| Development of immunoassay technologies contributing to nextgeneration vaccine science | SANO Kaori | National Institute of Infectious Diseases, Researcher |
| Study of HTLV-1-related pathogenesis via multiple disciplinary approach | SATO Yorifumi | Kumamoto University, Professor |
| Interdisciplinary Research on the Molecular Basis of the Liver Specificity on Malaria Parasite Infection | SHINZAWA Naoaki | Tokyo Medical and Dental University, Lecturer |
| Elucidation of molecular mechanisms of severe bacterial pneumonia based on spatial multi-omics analysis and establishment of novel infection control measures | SUMITOMO Tomoko | Tokushima University, Professor |
| Elucidation of stem cell carcinogenesis mechanism of HPV18-associated cervical cancer by integration of single-cell analysis technologies. | TAGUCHI Ayumi | Osaka University, Specially Appointed Researcher |
| Research and development for morbillivirus infections | TAKEDA Makoto | The University of Tokyo, Professor |
| Development of a human vascular infection model to evaluate the pathogenicity of Bartonella species and their contribution in tumorigenesis | TSUKAMOTO Kentaro | Fujita Health University, Senior assistant professor |
| Engineering natural products by Chem-Bio hybrid synthesis for drug discovery of dysentery amoebiasis | TSUNEMATSU Yuta | Nagoya University, Associate Professor |
| Integrated data science for deciphering the epigenomic code and molecular network of HTLV-1 infection and strategic drug discovery | YAMAGISHI Makoto | The University of Tokyo, Associate Professor |
| Study of transmission and pathogenesis of arthropod-borne virus and development of treatment for virus infection by interdisciplinary approaches | YOSHII Kentaro | Nagasaki University, Professor |
（In alphabet order of surnames）
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Creation of novel therapeutic strategies for nontuberculous pulmonary disease focusing on small airway disease | ASAKURA Takanori | Kitasato University, Assistant Professor |
| Discovery for pathogenic factors involved in the pathological progression of pulmonary nontuberculous mycobacterial infection and developmental studies for prognosis prediction | FUKANO Hanako | National Institute of Infectious Diseases, Senior Research Scientist |
| Control of aggravation of novel coronavirus infection by elucidation of endotheliopathy | MAISHI Nako | Hokkaido University, Assistant professor |
| Unravelling the molecular mechanism underlying virulence and transmission of Plasmodium falciparum | MIYAZAKI Shinya | Nagasaki University, Assistant Professor |
| The development of TMRPSS2 inhibitors for viral respiratory infection | YAMAMOTO Mizuki | The University of Tokyo, Senior Assistant Professor |
（In alphabet order of surnames）
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Multidisciplinary research into the molecular dissection of malaria for innovative cure and radical treatment | ANNOURA Takeshi | National Institute of Infectious Diseases Chief (Head of Division 3) |
| Production of novel monoclonal antibody focused on the inhibitory effects on Plasmodium sporozoite migration in the skin, which targets conserved CSP sequence | ISHINO Tomoko | Tokyo Medical and Dental University Professor |
| Platform development for novel therapeutic approaches to combat drug-resistant bacterial infections by integrating medical big data analysis, clinical pharmacology, and bacteriology | ISHIZAWA Keisuke | Tokushima University Professor |
| Development of computing/information platform for analysis of B-cell repertoires associated with infectious diseases | KURODA Daisuke | National Institute of Infectious Diseases Senior Research Scientist |
| Development of basic technology for drug discovery of antimalarial drugs that do not become resistant through integrated research of medicine, evolutionary chemistry, and information science | MITA Toshihiro | Juntendo University Professor |
| Understanding of regulated necrosis leads to the novel vaccine and drug development against infectious diseases | MORIWAKI Kenta | Toho University Associate Professor |
| Design and evaluation of molecularly-assembled antioxidant drugs that control cytokine storms | NAGASAKI Yukio | University of Tsukuba Professor |
| Elucidating the host-parasite interplay in Chagas cardiomyopathy and revolutionizing novel drug discovery/development through human iPS cardiomyocyte modeling | NAKAGAMA Yu | Osaka Metropolitan University Associate Professor |
| Development and optimization of HLA Class1-restricted HTLV-1-specific T-cell therapy through multidisciplinary fusion | NAKASONE Hideki | Jichi Medical University Associate Professor |
| Creation of novel therapeutic strategies for pulmonary NTM disease using artificial intelligence and genomic drug discovery | NAMKOONG Ho | Keio University Assistant Professor |
| CRISPR based RNA virus suppression technologies | NISHIMASU Hiroshi | The University of Tokyo Professor |
| Spatio-temporal analysis of nuclear compartments in virus-infected cells using AI-combined superresolution imaging | SATO Yoshitaka | Nagoya University Associate Professor |
| Comprehensive profiling of IgM against Plasmodium falciparum merozoite proteins for development of vaccines and point-of-care diagnosis kits for severe malaria | TAKASHIMA Eizo | Ehime University Associate Professor |
| Elucidation of the interaction between SARS CoV 2 and human glycan receptors and development of neutralizing antibodies | TATENO Hiroaki | National Institute of Advanced Industrial Science and Technology Group Leader |
（In alphabet order of surnames）
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Elucidation of the pathophysiology of the sequelae of coronavirus disease 2019 using a multidisciplinary approach | ISHII Makoto | Nagoya University Professor |
| Lipidomics metadata-based research on Entamoeba lipid metabolism; E. histolytica physiology and anti-amoebiasis drug development | MI-ICHI Fumika | Nagasaki University Professor |
| Characterization of Ebolavirus budding by single molecule approaches for development of novel therapeutics | NANBO Asuka | Nagasaki University Professor |
| Platform for rational drug design of mid-sized synthetic inhibitors targeting PPIs causing infectious diseases | OSAWA Masanori | Keio University Professor |
| Spatial and single cell transcriptomics to study pathogenesis of Severe Fever with Thrombocytopenia Syndrome | SUZUKI Tadaki | National Institute of Infectious Diseases Director |
| Study of environmental adaptation in pathogenic fungi | TAKAHASHI Hiroki | Chiba University Associate Professor |
（In alphabet order of surnames）
Completed Research Projects
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Development research on anti-paramyxoviruses based on virus-host interactome analysis | KATOH Hiroshi | National Institute of Infectious Diseases Chief |
| Development of broad-host-range biologics capable of killing drug resistant bacteria | KIGA Kotaro | National Institute of Infectious Diseases Chief |
| Fundamental and clinical study for elucidation of the onset mechanism of infant botulism |
KOBAYASHI Nobuhide | Kanazawa University Associate Professor |
| Development of an AI-based blood clot characterizer for COVID-19-related thrombosis and elucidation of its physiology with the characterizer | NISHIKAWA Masako | University of Tokyo Assistant Professor |
| Genetic dissection of artemisinin resistance of malaria parasites by combination of genetics and bioinformatics with field-isolate strains | SHINZAWA Naoaki | Tokyo Medical and Dental University Assistant Professor |
| Elucidation of mechanism underlying exacerbation of bacterial pneumonia following influenza infection for development of preventive and therapeutic measures against superinfection | SUMITOMO Tomoko | Osaka University Associate Professor |
| Study of visualization system for intracellular dynamics of highly pathogenic viruses by using cellular biological approach | TAKAMATSU Yuki | Nagasaki University Associate Professor |
| Study for anti (+)ssRNA virus agents by inducing G-quadruplexes | TERA Masayuki | Tokyo University of Agriculture and Technology Associate Professor |
| Development of anti-amoebic dysentery drug stand on complexity generating chem/biological hybrid biosynthesis | TSUNEMATSU Yuta | Nagoya University Associate Professor |
| Deep exploration for retrovirus reservoir heterogeneity and host-virus interaction by multi-phase single-cell epigenetic analysis | YAMAGISHI Makoto | The University of Tokyo Project lecturer |
（In alphabet order of surnames）
| Project Title | Principal Investigator | Affiliation, Position |
|---|---|---|
| Elucidation of molecular basis of persistent infection by herpesviruses through single cell analysis | ARII Jun | Kobe University Specially Appointed Associate Professor |
| Development of novel antibiotic lead compounds for intractable bacteria based on innovative natural product discovery approach | ASAI Teigo | Tohoku University Professor |
| Elucidation of properties and evolutionary mechanisms of virome involed in progress of pathogenesis | FUKUHARA Takasuke | Hokkaido University Professor |
| Drug developments based on the study of molecular mechanisms of paramyxovirus infections in the central nervous system | HASHIGUCHI Takao | Kyoto University Professor |
| Interdisciplinary study for grouping HBV patients and finding an optimal drug strategy based on “Hybrid” big data | IWAMI Shingo | Nagoya University Professor |
| Single-cell analysis of immune dynamics in HTLV-1 infection and its related disorders | KATAOKA Keisuke | National Cancer Center Japan Chief |
| Elucidation of SARS-CoV-2 transmission mechanism using advanced forward and reverse genetics | MAKINO Akiko | Kyoto University Assistant Professor |
| Multidiscipline research of EBV infection and Oncogenesis | MURATA Takayuki | Fujita Health University Professor |
| Dissection of host liquid-phase as a target for antiviral therapy and vaccine development | SAITO Akatsuki | University of Miyazaki Associate Professor |
| Idetification of surrogate markers for the prediction of HTLV-1-related diseases by multiple-layered single cell analysis | SATO Yorifumi | Kumamoto University Professor |
| Study of HPV-18 persistent infection and carcinogenesis in the squamocolumnar junction cells using novel culture technologies | TAGUCHI Ayumi | The University of Tokyo Assistant Professor |
| Elucidating the regulatory mechanism of influenza virus propagation by liquid-liquid phase separation | TAKIZAWA Naoki | Microbial Chemistry Research Foundation Researcher |
| Investigation of the role of host aging and local environment in invasive pneumococcal disease | YAMAGUCHI Masaya | Osaka University Assistant Professor |
| Signalo-geometrical and computational fluid dynamics analysis of lymph node local B-cell responses as a basal domain of virus-neutralizing antibody induction | YAMAMOTO Hiroyuki | National Institute of Infectious Diseases Chief |
| Atomic-level elucidation of host defense to disrupt Toxoplasma-containing vacuole disruption and of the parasite counterdefense mechanism | YAMAMOTO Masahiro | Osaka University Professor |
（In alphabet order of surnames）
Evaluation and Management System
- Program Supervisor (PS)
-
- KANDA Tadahito, Honorary member, National Institute of Infectious Diseases
- Program Officer (PO)
-
- DOI Yohei, Professor, Fujita Health University
- KITA Kiyoshi, Dean and Professor, Nagasaki University
- MATSUURA Yoshiharu, Director, Osaka University
- MITSUYAMA Masao, Professor Emeritus, Kyoto University
- SATO Hironori, Senior Researcher, National Institute of Infectious Diseases
- SHIROZU Mikako, Team Leader, RIKEN
- TANAKA Mayumi, President, MT Development Consulting
- YANAGI Yusuke, Professor, Nagasaki University
Completed programs
Brochures
For more information about the program, please refer to the brochure below.
The 25 research projects funded under this program (the joint research meeting booklet from March 2021)Last updated 06/20/23