News Releases & Research Results Prevention of dry eye disease with ω-hydroxy lipids in tear film - For the development of a new treatment for dry eye disease -

• The results of research conducted by Professor Akio Kihara of the Faculty of Pharmaceutical Sciences, Hokkaido University.

• Omega-hydroxy lipids in tear film were demonstrated to prevent dry eye disease.
• Furthermore, the synthase of omega-hydroxy lipids was successfully identified, and mice lacking this enzyme could not produce the lipids, resulting in dry eye disease. Various omega-hydroxy lipids were found in tears.
• The results of this research should facilitate the development of innovative new treatments for dry eye disease by targeting the lipids in tears.

This research project was conducted with the support of the Advanced Research and Development Programs for Medical Innovation (AMED-CREST) by AMED.

The results of research were published in eLife on April 7.

Miyamoto M., et al. Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease eLife
DOI：10.7554/eLife.53582