News Releases & Research Results Elucidation of the chronic mechanisms of acute kidney injury using Mincle, a sensor for cell death - Development of novel preventive methods for chronic kidney diseases -

News Releases & Research Results

Outline

The results of research and development project conducted by Professor Takayoshi Suganami, Lecturer Miyako Tanaka, Professor Shoichi Maruyama, and researcher Marie Saka of the Research Institute of Environmental Medicine/Graduate School of Medicine, Nagoya University, and Professor Yoshihiro Ogawa of Kyushu University Graduate School of Medicine.

The key results of R&D are as follows:

  • Mincle (macrophage-inducible C-type lectin) expressed in microphages was demonstrated to be involved in the pathological progression from acute kidney injury to chronic kidney disease.
  • Specifically, Mincle detects necrotic tubules in a mouse model of acute renal injury, resulting in chronic inflammation. Furthermore, activated Mincle increases the production of macrophage inflammatory cytokines and suppresses the phagocytosis of dead cells.
  • The results of this R&D project should facilitate the development of novel preventive methods for chronic kidney diseases.

This program was conducted with the support of the Advanced Research & Development Programs for Medical Innovation by AMED

The results were published in the international scientific journal Journal of Experimental Medicine on August 14.

Article

Tanaka M., et al. C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury Journal of Experimental Medicine
DOI:10.1084/jem.20192230

08/17/20

Last updated 08/17/20