News Releases & Research Results Development and validation of new diagnostic criteria for allergic bronchopulmonary mycosis

The results of the collaborative research project conducted by Professor Koichiro Asano of the Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, and others.

• The research group proposed new diagnostic criteria for allergic bronchopulmonary mycosis (ABPM) that had been difficult to diagnose with conventional diagnostic criteria and also validated that they provide a more sensitive and accurate diagnosis.
• The newly proposed diagnostic criteria enabled highly accurate diagnosis of ABPM with a sensitivity of 94–96% while maintaining a specificity of 90%. Moreover, the diagnostic sensitivity of ABPM caused by non-Aspergillus fungi was 90.5%, which was markedly higher than that of the conventionally used Rosenberg-Patterson criteria (14.3%) and the International Society for Human and Animal Mycology criteria proposed in 2013 (47.6%).
• The results of this research project should help reduce delays in the diagnosis of ABPM and to establish proper therapies to be applied before bronchus and lung destruction progress.

This research project was conducted with the support of the Practical Research Project for Allergic Diseases and Immunology by AMED.

The results of this research project were published online in Journal of Allergy and Clinical Immunology on September 10.

Asano K., et al. New Clinical Diagnostic Criteria for Allergic Bronchopulmonary Aspergillosis/Mycosis and its Validation Journal of Allergy and Clinical Immunology
DOI：10.1016/j.jaci.2020.08.029