News Releases & Research Results Identification of genomic abnormalities involved in the onset and progression of dedifferentiated liposarcoma ― development of the database toward the implementation of precision medicine for soft tissue sarcomas

News Releases & Research Results


The results of collaborative research led by Project Lecturer (at the time of the research) Makoto Hirata, Assistant Professor Kotoe Katayama, and Associate Professor (at the time of the research) Rui Yamaguchi of the Institute of Medical Science, the University of Tokyo, Professor Koichi Matsuda of the Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, the University of Tokyo, Volunteer Trainee (at the time of the research) Naofumi Asano and Department of Clinical Genomics Hitoshi Ichikawa from the National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Kyushu University, Osaka International Cancer Institute, the Chiba Cancer Center, Nagoya University, the Kanagawa Cancer Center, the Hokkaido Cancer Center, RIKEN, and others.

The key results of research are as follows

  • A comprehensive genomic analysis of dedifferentiated liposarcoma (*), one of malignant soft tissue tumors, was performed through the Japanese Sarcoma Genome Consortium (The Office: the Institute of Medical Science, the University of Tokyo) that conducts research on genome sequencing by collecting samples of malignant bone and soft tissue tumors (sarcoma) as a rare cancer from all over Japan.
    * A type of malignant tumor that develops in soft tissues, such as subcutaneous tissues or muscles. Tumor cells similar to fat cells grow to form tumors, which is the most common tumor among soft tissue sarcomas.
  • Based on the results of a comprehensive genome sequencing obtained from samples of 115 patients with soft tissue sarcoma, the study identified the characteristics of gene abnormalities involved in the stages of onset and progression of dedifferentiated liposarcoma.
  • Further analyses and efforts to expand the database are expected to advance precision medicine for malignant bone and soft tissue tumors.

This project was conducted with the support of Project for Cancer Research and Therapeutic Evolution, Project for Development of Innovative Research on Cancer Therapeutics, and Practical Research for Innovative Cancer Control by AMED.

The results of research were published in Nature Communications, a British online scientific journal, on December 12.


Hirata M., et al. Integrated exome and RNA sequencing of dedifferentiated liposarcoma Nature Communications



Last updated 12/13/19