News Releases & Research Results Identification of an intracellular signal critical for the development of head and neck cancer - Creation of a mouse model for the fastest cancer development -

News Releases & Research Results

Outline

The results of collaborative research and development conducted by Professor Akira Suzuki and Associate Professor Tomohiko Maehama of Kobe University Graduate School of Medicine and Dr. Muneyuki Masuda of Kyushu Cancer Center.

The key results of R&D are as follows:

  • Mice carrying mutations in the signaling pathway of transcription cofactor Yes-Associated Protein (YAP) were found to develop head and neck cancer in a very short period of time.
  • Specifically, the loss of MOB1 (a brake on YAP) and the strong activation of YAP in the tongue of the cancer mouse model caused cancer in a short period of time (at about one week).
  • The cancer mouse model, created through the R&D, should serve as an excellent resource for general cancer research as well as for new drug development for head and neck cancer.

This R&D project was conducted with the support of Practical Research for Innovative Cancer Control by AMED.

The results of R&D were published in an American scientific journal, Science Advances, on March 19.

Article

Omori, H, et al. YAP1 is a Potent Driver of the Onset and Progression of Oral Squamous Cell Carcinoma Science Advances
DOI:10.1126/sciadv.aay3324

03/19/20

Last updated 03/19/20