News Releases & Research Results Optical biopsy for the immediate diagnosis of cancer without excision - Stereoscopic observation without tissue damage by imaging, followed by AI-based automatic diagnosis -

The results of the collaborative R&D project conducted by Professor Masaru Ishii of the Department of Immunology and Cell Biology, Associate Professor Takahiro Matsui of the Department of Pathology, and Professor Tadashi Kimura of the Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Professor Kiyoko Kato of the Department of Gynecology and Obstetrics, Kyushu University Graduate School of Medicine, and Yasujiro Kiyota of Nikon Corporation.

• In vivo real-time three-dimensional observation of cervical tissues without formalin fixation or staining was realized using biological imaging technology with a multiphoton excitation microscope.
• Cervical cancers could be diagnosed more rapidly and quantitatively than conventional diagnostic methods without tissue damage by combining the observation technology with image analysis based on artificial intelligence (AI).
• The results of R&D should be applied to medical devices to realize less invasive and more rapid and quantitative diagnosis of cancer tissues than conventional methods.

This program was conducted with the support of the Development of Medical Devices and Systems for Advanced Medical Services by AMED.

The results of this R&D project were published online in the American Cancer Society’s journal Cancer Research on July 23.

Matsui T., et al. Nonlinear optics with near-infrared excitation enable real-time quantitative diagnosis of human cervical cancers Cancer Research
DOI：10.1158/0008-5472.CAN-20-0348