News Releases & Research Results Enhanced therapeutic effects of EGFR inhibitors by transdermal administration of tumor-suppressive miRNA-634 - For practical applications of microRNA ointment for squamous cell skin cancer -

News Releases & Research Results


The results of the collaborative research and development project conducted by Associate Professor Jun Inoue and Professor Johji Inazawa of the Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University and MEDRx Co., Ltd.

The key results of R&D are as follows:

  • An ointment containing “miR-634,” a tumor-suppressive microRNA, was developed.
  • The ointment was demonstrated to have antitumor effects and combined effects with EGFR inhibitors using mouse models of cutaneous squamous cell cancer and chemical carcinogenesis in the skin.
  • The results of this R&D should promote the practical applications of new anticancer nucleic acid therapeutics with microRNA.

This project was conducted with the support of the Project for Cancer Research and Therapeutic Evolution by AMED.

The results were published online in the international scientific journal Molecular Therapy - Oncolytics on November 23.


Inoue J., et al. Improving the efficacy of EGFR inhibitors by topical treatment of cutaneous squamous cell carcinoma with miR-634 ointment Molecular Therapy - Oncolytics
DOI: 10.1016/j.omto.2020.10.009


Last updated 11/24/20