News Releases & Research Results Temperature-dependent malignant progression of breast cancer - Elucidation of new molecular mechanisms including exosomes responsible for cancer metastasis -

The results of research conducted by Professor Takahiro Ochiya of the Institute of Medical Science, Tokyo Medical University, and Senior Staff Scientist Yusuke Yamamoto and Visiting Fellow Kurataka Otsuka of the Division of Cellular Signaling, National Cancer Center Research Institute.

• Temperature, one of the environmental factors of cancer, contributes to the malignant progression of breast cancer. Mechanisms by which exosome secretion, which influences cancer microenvironments (e.g., metastasis), increase in a temperature-dependent manner were partially elucidated.
• The results of this research project should facilitate the elucidation of new mechanisms of metastasis, identification of new biomarkers, and research on exosome-targeting cancer treatment through the accumulation of findings on exosome biology.

This project was conducted with the support of the Project for Cancer Research and Therapeutic Evolution (P-CREATE) by AMED.

The results were published in Journal of Extracellular Vesicles on December 31.

Otsuka K., et al. Uncovering temperature-dependent extracellular vesicle secretion in breast cancer Journal of Extracellular Vesicles
DOI: 10.1002/sctm.20-0269