Division of Infectious Disease Research List of Projects -Japanese Initiative for Progress of Research on Infectious Disease for global Epidemic (J-PRIDE)

Core Research Program

Principal Investigator	Affiliation		Project Title
Shigeru Kohno	Nagasaki University	President	Establishment of the research base for BSL-4 facility and capacity building of researchers on 'category I' (highly pathogenic) pathogen

Open Research program

1.Research on viral infectious diseases that are extremely lethal to humans

1-(1) Research on viruses belonging to the Arenaviridae, Filoviridae and Bunyaviridae families, etc.

Principal Investigator	Affiliation		Project Title
Manabu Igarashi	Hokkaido University	Associate Professor	Structural bioinformatics to investigate protein functions of highly pathogenic viruses
Tadaki Suzuki	National Institute of Infectious Diseases	Chief	Investigation of pathogenesis of SFTS using comprehensive immunoglobulin gene repertoire analysis
Takeshi Noda	Kyoto University	Professor	Molecular mechanisms of Lassa virus replication

2. Research on infection control mechanism and interactions between pathogens and host factors

2-(1) Exploratory research to establish new treatment concepts based on understanding of infectious diseases

Principal Investigator	Affiliation		Project Title
Hisashi Arase	Osaka University	Professor	Regulation of infectious diseases targeting for paired receptors
Hiroshi Katoh	National Institute of Infectious Diseases	Senior Researcher	Omics analysis of host-virus interactions in the paramyxovirus infection
Kei Sato	The University of Tokyo	Associate Professor	Next-generation investigation leading to HIV/AIDS cure through systems virology approach
Tomoko Sumitomo	Osaka University Graduate School of Dentistry	Associate Professor	Exploration of host and bacterial factors contributing to exacerbation of bacterial pneumonia following influenza infection for development of preventive and therapeutic measures against superinfection
Noriyuki Nishida	Nagasaki University	Professor	Establishment of method for prediction of emergence drug resistant RNA viruses and rapid in silico drug design
Takasuke Fukuhara	Osaka University	Associate Professor	Identification of novel RNA viruses involved in pathogenesis and prognosis of patients after liver transplantation
Yukako Fujinaga	Kanazawa University	Professor	Exploratory research into environmental factor(s) in intestine influencing on infant botulism

2-(2) Research on molecular mechanism in the formation, maintenance and reactivation of latent and persistent infections

Principal Investigator	Affiliation		Project Title
Norifumi Iijima	National Institutes of Biomedical Innovation, Health and Nutrition	Sub-project leader	Dissecting the mechanism of latent virus reactivation by focusing on the function of tissue-resident memory T cells
Yorifumi Satou	Kumamoto University	Professor	Elucidation of key mechanisms of persistent/latent HTLV-1 infection by analyzing single cell data with data mining technique
Ayumi Taguchi	Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital	Clinical fellow	Elucidation of regulatory mechanisms for latent infection in progenitor cells and molecular mechanisms for virus reactivation along with cell differentiation
Keizo Tomonaga	Kyoto University	Professor	Analysis of the evolutionary strategy of RNA virus persistent infection in the nucleus
Hideki Nakasone	Jichi Medical University	Assistant Professor	Molecular mechanisms of immune escape in viral reactivations and host immune reconstitutions following hematopoietic cell transplantation
Takayuki Murata	Fujita Health University	Professor	Reactivation of EBV: leveraging novel clinical data and creative technologies
Hiroyuki Yamamoto	National Institute of Infectious Diseases	Chief (Group leader)	Analysis of B-cell Akt modulation-based virus-neutralizing antibody induction designed from animal AIDS models and development of its novel quantitative prediction model
Masahiro Yamamoto	Osaka University	Professor	Elucidation of host factors involving PCVs to develop a novel therapeutic strategy against protozoan pathogens
Koichi Watashi	National Institute of Infectious Diseases	Senior Researcher	Clarification of the determinant for chronicity of infection by analyzing dynamics of viral infection network

2-(3) Research on the molecular mechanism of transplacental infections or infections caused by blood-brain barrier failure

Principal Investigator	Affiliation		Project Title
Yasutoshi Kido	University Public Corporation Osaka, Osaka City University	Associate Professor	Metabolic interaction between pathogens and hosts in the course of central nerve system invasion by African Trypanosome
Cevayir Coban	The University of Tokyo	Professor	Brain-specific immuno-pathogenesis during systemic malaria infection; BBB disruption and beyond
Takao Hashiguchi	Kyushu University	Associate Professor	Structure‑guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system
Masaaki Murakami	Hokkaido University	Director, Professor	Investigation of gateway reflex-mediated entry site formation for pathogen invasion

3. Research on pathogen ecosystems based on the "one health" concept

3-(1) Research on the environmental adaptation mechanisms of pathogens in ecosystems

Principal Investigator	Affiliation		Project Title
Hiroki Takahashi	Chiba University	Associate Professor	Understanding of adaptation heterogeneity by mathematical modelling in pathogenic fungus Aspergillus fumigatus
Fumika Mi-ichi	Saga University	Research Associate	Sulfolipid metabolism of Entamoeba histolytica - New targets of anti-amebic drug and amoebiasis transmission blocking drug -

3-(2) Research on the molecular mechanism that determines the host range of　pathogens

Principal Investigator	Affiliation		Project Title
Masatoshi Okamatsu	Hokkaido University	Associate Professor	Study on novel receptor novel receptor structures involved in interspecies transmission of influenza viruses

3-(3) Research on new treatment methods for drug-resistant pathogens

Principal Investigator	Affiliation		Project Title
Ken Daniel Inaoka	Nagasaki University	Assistant Professor	Targeting novel isocitrate metabolism involved in adaptation to host environment from African trypanosome
Longzhu Cui	Jichi Medical University	Professor	Development of a novel tracking type antimicrobial therapy against antibiotic-resistant bacteria
Tomohiro Sawa	Kumamoto University	Professor	Development of a novel chemotherapeutic strategy targeting bacterial oxidative stress resistance
Ichiro Nakagawa	Kyoto University	Professor	Development of a new bacterial species-specific growth inhibitory drug based on molecular interaction