News Releases & Research Results Study successfully develops a new three-dimensional model to reconstruct the morphogenesis of the early mouse embryo using only gene expression data

Results of research and development by a group of Assistant Professor Tomoya Mori of the Bioinformatics Center, Institute for Chemical Research, Kyoto University, Professor Wataru Fujibuchi of the Department of Life Science Frontiers, CiRA, Kyoto University, and others.

• Historically, 3-dimensional analysis of embryonic development has required information about both the spatial positions of cells and gene expression in each cell. However, in this study, a new computational model to reconstruct the three-dimensional morphology of the early mouse embryo was successfully developed using data on only 18 genes.
• This is expected to be applied to the analysis of quality identification, etc. of artificial tissues derived from iPS cells such as organoids (three-dimensional tissues differentiated and induced from diverse stem cells or tissue stem cells) in the future.

This research and development was conducted with the support of Research Center Network Program for Realization of Regenerative Medicine - Core Center for iPS Cell Research by AMED.

The results of research and development were published on August 29 in Scientific Reports, a British scientific journal.

Mori T., et al. Novel computational model of gastrula morphogenesis to identify spatial discriminator genes by self-organizing map (SOM) clustering, Scientific Reports
DOI：10.1038/s41598-019-49031-1