News Releases & Research Results A project (J-TRC) to recruit 20,000 healthy individuals aged 50-85 in the preclinical and prodromal stages of dementia for the largest domestic online study for the development of future therapeutic and prophylactic agents

The Graduate School of Medicine and Faculty of Medicine, University of Tokyo, and the University of Tokyo Hospital will start the largest domestic project “Research for the Construction of Trial Ready Cohort (J-TRC)” on October 31 (Thu) for recruiting participants in an online study on preclinical ^(*1) and prodromal ^(*2) dementia, with a goal of early commercialization of therapeutics and prophylactic agents for dementia.

^(*1) Preclinical stage: Pathological changes without dementia symptoms.
^(*2) Prodromal stage: Mild cognitive impairment.

• After obtaining consent and registering basic information through the website, the researchers will conduct two cognitive function tests, which can be completed within about 15 minutes, on the participants.
  Subsequently, the tests will be repeated on the Internet every three months to measure changes over time. Those suspected of having an increased risk of developing AD in the future can participate in a second-stage study (work-up, including blood tests and imaging) which will be conducted at a medical research institution.
• As a result of participation in the second-stage study, those who desire participation in clinical trials will receive information on the clinical trials on acceptable therapeutic and prophylactic drugs.
• Professor Takeshi Iwatsubo represents the research and development of the research team. The research team of the University of Tokyo plays a major role in promoting the research in collaboration with academic societies, medical research institutions throughout Japan, pharmaceutical companies, and foreign countries.

This project was implemented with the support of the Research and Development Grants for Dementia of the AMED.