News Releases & Research Results Genomic analysis for uterine adenomyosis identifies genetic mutations associated with the concurrence of disease onset and uterine endometriosis; elucidation of the pathogenesis of adenomyosis is expected
News Releases & Research Results
The key results of research are as follows
- Characteristic genetic mutations associated with uterine adenomyosis* were identified for the first time in the world.
*Uterine adenomyosis is a benign gynecological condition in which endometrium-like tissues appear in the uterine myometrium. It may be associated with intense menstrual pain, and may also lead to infertility.
- Specifically, the genome analysis of patients with uterine adenomyosis combined with uterine endometriosis was conducted, and the analysis data was collated with the patients’ clinical information. As a result, uterine adenomyosis was found to be an oligoclonal proliferation disease associated with genomic abnormalities.
- The research results revealed a mechanism for the frequent concurrence of uterine endometriosis and uterine adenomyosis.
This project was conducted with the support of Project for Cancer Research and Therapeutic Evolution (P-CREATE) and Project for Whole Implementation to Support and Ensure the Female Life (WISE) by AMED.
The research results were published in Nature Communications, a British scientific journal available online, on December 19.
Inoue S., et al. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutationseLife
Last updated 12/19/19