News Releases & Research Results Development of a monitoring method for tumorigenicity following iPS cells transplantation: Visualization of tumorigenic changes of neural stem/progenitor cells

News Releases & Research Results


The results of a collaborative research conducted by Professor Hideyuki Okano of the Department of Physiology, Professor Masaya Nakamura and Assistant Professor Yuji Tanimoto of the Department of Orthopedic Surgery, Keio University School of Medicine, Chief Researcher Tomoteru Yamasaki and Director Ming-Rong Zhang of the Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology and others.

The key results of study are as follows:

  • Tumorigenic change* (which is a concern following iPS cells transplantation) were successfully detected in vivo for the first time by clinically applicable positron emission tomography (PET) imaging of undifferentiated neural cells in a mouse model, where human iPS cell-derived neural stem/progenitor cells were transplanted.
    * Tumor formation after long-term residual undifferentiation following transplantation of neural stem/progenitor cells derived from a part of iPS cell lines into an animal model of spinal cord injury.
  • The results of the study will serve as an in vivo cell monitoring technique to observe clinical processes following transplantation of pluripotent stem cell-derived neural stem/progenitor cells in patients with spinal cord injury or brain trauma.

This project was conducted with the support of Research Center Network for Realization of Regenerative Medicine by AMED.

The study results were published in the journal STEM CELLS Translational Medicine on January 6.



Last updated 01/06/20