News Releases & Research Results Repair of articular cartilage damage by transplantation of allogeneic iPS cell-derived cartilage

The results of the collaborative research and development led by Professor Noriyuki Tsumaki of the Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Professor Shuichi Matsuda of the Department of Orthopedic Surgery, Kyoto University Hospital, and others.

• A protocol for regenerative medicine to treat knee joint cartilage damage with human iPS cell-derived cartilage was submitted to the Minister of Health, Labour and Welfare on November 7, 2019.
• The protocol was approved by the Health Sciences Council held on January 24 (Fri), 2020, because it met the criteria for regenerative medicine.
• In the future clinical study, cartilage tissue will be prepared from chondrocytes derived from an iPS cell stock to be transplanted into the knee joint cartilage lesions of four patients. Subsequently, the patients will be followed up for one year.

This R&D project was conducted with the support of Research Project for Practical Applications of Regenerative Medicine, and Research Center Network for Realization of Regenerative Medicine by AMED.