News Releases & Research Results Postulated action mechanism of anti-PD-1 antibody for Hodgkin Lymphoma - Transfer of PD-L1/L2 from cancer cells to cancer-supporting monocytes/macrophages through trogocytosis -

News Releases & Research Results


The results of collaborative research conducted by Graduate student Masaharu Kawashima, Professor Ai Kotani of the Institute of Medical Science, Tokai University, Lecturer Carreras Esteban Joaquim, and Professor Naoya Nakamura of the Department of Pathology, Tokai University School of Medicine.

The key results of research are as follows:

  • In classical Hodgkin lymphoma *1, PD-L1/L2 on the cell membrane was demonstrated to be transferred from cancer cells to their surrounding monocytes/tumor-associated macrophages (TAMs) *2.
    *1: Malignant lymphoma in which lymphocytes, a blood component, become cancerous and develop lumps mainly in the systemic lymph nodes.
    *2: Macrophages that infiltrate and accumulate in tumor tissue and exert immunosuppressive effects to promote tumorigenesis.
  • Further investigation should elucidate the pathological effects of surrounding immune cells on cancer and develop new therapies for inhibiting direct contact between cancer cells and monocytes/TAMs.

This research project was conducted with the support of the Program for Basic and Clinical Research on Hepatitis and the Advanced Research and Development Programs for Medical Innovation (PRIME) by AMED.

The results of research were published in Leukemia on February 24.



Last updated 02/24/20