News Releases & Research Results Development of engineered immune cells sensing pathogenic virus with high sensitivity to prevent infection

News Releases & Research Results


The results of collaborative research and development led by Professor Akihide Ryo and Assistant Professor Satoko Matsunaga of Department of Microbiology, Yokohama City University School of Medicine; Department of Immunology, Yokohama City University School of Medicine; National Institute of Infectious Diseases; and National Center for Global health and Medicine.

The key results of R&D are as follows:

  • A customization of extracellular and intracellular portions of the “synNotch receptor,” a membrane protein developed for immunological therapy for cancer, led to the successful development of engineered immune cells sensing Hepatitis B Virus (HBV) surface antigen prior to enhancement of intracellular transcription.
  • It was confirmed at the cellular level that activated engineered immune cells can control HBV transmission through the secretion of a neutralizing antibody—an antibody with the capacity to inhibit viral infection—and interferon.
  • The results of R&D suggested that engineered immune cells with synNotch receptor may be an important tool for development of novel treatment for intractable infectious diseases.

This R&D project was conducted with the support of Research Program on Hepatitis by AMED.

The results of R&D were published in iScience , a multidisciplinary open access journal published by Cell Press, on February 27.



Last updated 02/27/20