News Releases & Research Results Identification of calcium and integrin-binding protein 1 as a novel molecule involved in the early pathogenesis of Alzheimer's disease
News Releases & Research Results
The results of collaborative research conducted by Professor Taisuke Tomita, Lecturer Yukiko Hori, and Graduate student Yung Wen Chiu of the University of Tokyo Graduate School of Pharmaceutical Sciences, Professor Takeshi Ikeuchi of Niigata University Brain Research Institute, and others.
The key results of research are as follows:
- In the mechanism of onset of Alzheimer's disease (AD), which has yet to be fully elucidated, “amyloid β peptide (Aβ)” accumulates as the earliest stage of pathogenesis. The research group identified calcium and integrin-binding protein 1 (CIB1), a novel molecule involved in Aβ production, and clarified the mechanism through which it regulates Aβ production.
- Particularly, through the identification of the novel Aβ production regulator CIB1 using the CRISPR/Cas9 genome-editing tool and elucidation of its regulatory mechanism, the research group showed that changes in the CIB1 expression level might be involved in the development of AD.
- The results of research should lead to the establishment of new therapies for Alzheimer's disease.
This research project was conducted with the support of the Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) by AMED.
The results of research were published in The FASEB Journal on April 20.
Yung Wen Chiu, et al. Identification of calcium and integrin-binding protein 1 as a novel regulator of production of Amyloid β peptide using CRISPR/Cas9-based screening system The FASEB Journal
Last updated 04/20/20