News Releases & Research Results Treatment of malignant tumors by “poison control by poisoning” - A novel therapeutic strategy for refractory tumors by reverse thinking -

The results of research conducted by Associate Professor Mikiko Suzuki and Professor Masayuki Yamamoto of the Tohoku University Graduate School of Medicine.

• The effectiveness of a novel therapy for tumors resistant to anticancer drugs and radiation therapy was demonstrated in a mouse experiment.
• Specifically, the progression of treatment-resistant tumors with the activation of transcription factor Nrf2, a DNA-binding protein that regulates gene expression, could be suppressed by activating Nrf2 in surrounding normal cells.
• Activation of transcription factor Nrf2 should protect normal cells and provide a novel therapy with few side effects.

This program was conducted with the support of the Project for Cancer Research and Therapeutic Evolution (P-CREATE) by AMED.

The results of this research project were published online in the academic journal Cancer Research (American Cancer Society) on July 8.

Hayashi M., et al. Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors Cancer Research
DOI：10.1158/0008-5472.CAN-19-2888