News Releases & Research Results Multiomics analysis of HIV-1-infected cells in vivo - Clues for the development of an HIV-1 cure -

2020.7.15News Releases & Research Results

Outline

The results of research and development by Associate Professor Kei Sato of the Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, and others.

The key results of research are as follows:

  • An HIV-1 infection model was created using a small animal model “humanized mouse.” The samples collected were subjected to multiomics analysis*, revealing the multifaceted characteristics of HIV-1 infected cells in vivo.
    *A research method for global genetic and gene expression analyses.
  • Specifically, HIV-1-infected cells in vivo are a heterogeneous cell population with various characteristics. Of these cells, those that strongly express “CXCL13,” a type of cell chemokine, and those that weakly express the interferon-inducible genes may contribute to efficient viral spread in vivo.
  • The results of this R&D project should provide a foundation for basic research to develop an HIV-1 cure.

This project was conducted with the support of the Japanese Initiative for Progress of Research on Infectious Disease for Global Epidemic (J-PRIDE) by AMED.

The results of this R&D project were published online in the American scientific journal Cell Reports on July 15.

Article

Aso H., et al. Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo Cell Reports
DOI:10.1016/j.celrep.2020.107887

Last updated 2020.7.15