News Releases & Research Results Multiomics analysis of HIV-1-infected cells in vivo - Clues for the development of an HIV-1 cure -
2020.7.15News Releases & Research Results
The key results of research are as follows:
- An HIV-1 infection model was created using a small animal model “humanized mouse.” The samples collected were subjected to multiomics analysis*, revealing the multifaceted characteristics of HIV-1 infected cells in vivo.
*A research method for global genetic and gene expression analyses.
- Specifically, HIV-1-infected cells in vivo are a heterogeneous cell population with various characteristics. Of these cells, those that strongly express “CXCL13,” a type of cell chemokine, and those that weakly express the interferon-inducible genes may contribute to efficient viral spread in vivo.
- The results of this R&D project should provide a foundation for basic research to develop an HIV-1 cure.
This project was conducted with the support of the Japanese Initiative for Progress of Research on Infectious Disease for Global Epidemic (J-PRIDE) by AMED.
The results of this R&D project were published online in the American scientific journal Cell Reports on July 15.
Aso H., et al. Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo Cell Reports
Last updated 2020.7.15