News Releases & Research Results Unknown effects of intestinal flora on the spread of systemic inflammation

The results of the research project conducted by graduate student Hina Kosakamoto, Lecturer Fumiaki Obata, and Professor Masayuki Miura of the Graduate School of Pharmaceutical Sciences, the University of Tokyo.

• Systemic inflammatory responses and shortened individual lifespan, observed upon local induction of (cell) necrosis in Drosophila wings, were significantly suppressed under aseptic conditions.
• Specifically, as a result of distant host-bacterial interactions, necrosis of tissues other than the intestinal ones induces changes in the intestinal flora, exacerbating systemic inflammatory responses.
• The results of this research should facilitate the understanding of the mechanism of malignant transformation of diseases due to disturbed intestinal flora.

This program was conducted with the support of the Advanced Research and Development Programs for Medical Innovation (PRIME) by AMED.

The results of this research project were published in Cell Reports on July 22.

Kosakamoto H., et al. Local necrotic cells trigger systemic immune activation via gut microbiome dysbiosis in Drosophila Cell Reports
DOI：10.1016/j.celrep.2020.107938