News Releases & Research Results Identification of potential susceptibility genes for Japanese familial pancreatic cancer - To overcome pancreatic cancer -

News Releases & Research Results


The results of collaborative research by Professor Shinichi Yachida of the Graduate School of Medicine/Faculty of Medicine, Osaka University, Professor Toru Furukawa of Tohoku University Graduate School of Medicine, National Cancer Center, Tokyo Women's Medical University, Kyorin University, and Mizuho Information & Research Institute, Inc.

The key results of research are as follows:

  • Potential susceptibility genes for the Japanese familial pancreatic cancer (*) were successfully identified.
    *Two or more family members (parents or siblings) develop pancreatic cancer.
  • Specifically, potential susceptibility genes (ATM, BRCA2, BRCA1, CHEK2, and PALB2) for the Japanese familial pancreatic cancer and novel candidate genes (FAT4, FAT1, and SMAD4) were identified by germline whole-exome sequencing analysis in 81 patients with familial pancreatic cancer.

This program was supported by the Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT) by AMED.

The results of this research project were published in the American scientific journal Annals of Surgery on August 8.


Takai E., et al. Whole-exome Sequencing Reveals New Potential Susceptibility Genes for Japanese Familial Pancreatic Cancer Annals of Surgery
DOI: 10.1097/SLA.0000000000004213


Last updated 08/11/20