News Releases & Research Results Identification of the genes responsible for oocyte morphogenesis - Mass production of egg cytoplasm -

News Releases & Research Results


The results of research conducted by Professor Katsuhiko Hayashi and Assistant Professor Nobuhiko Hamazaki (currently Washington University/HHMI Research Fellow) of the Graduate School of Medical Sciences, Kyushu University, and Team Leader Tomoya Kitajima and Visiting Research Fellow Hirohisa Kyogoku of the RIKEN Center for Biosystems Dynamics Research.

The key results of research are as follows:

  • Large amounts of oocyte-like cells were successfully produced in a short time by identifying the genes responsible for mouse oocyte morphogenesis and introducing these genes into embryonic stem (ES) and induced pluripotent stem (iPS) cells.
  • The results of this research should facilitate the elucidation of the formation mechanism of oocyte cytoplasm required for ontogenesis and the development of fertility treatment with artificial oocyte cytoplasm.

This project was conducted with the support of AMED.

The results were published in the American scientific journal Nature on December 17.


Hamazaki K., et al. Reconstitution of the oocyte transcriptional network with transcription factors Nature
DOI: 10.1038/s41586-020-3027-9


Last updated 12/17/20