Calls for Proposals AMED selected R&D projects to adopt for the FY 2018 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME)


Status of Grants/Funding Opportunities Awarded projects
R&D phase Basic Study
Key Fields Other programs(1st)
Division of Emerging Research, Department of Research Infrastructure
E-mail: kenkyuk-kobo “AT” (Please replace “AT” with “@”)
Please contact us, preferably by e-mail using the above contact information.

Adoption contents

AS a result of scrupulous deliberation conducted by a Project Evaluation Panel, Japan Agency for Medical Research and Development (AMED) selected the R&D projects to adopt for the FY 2018 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME) as follows:

R&D Area: Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms
Tissue Adaptation and Repair)

Unit-type (AMED-CREST)

Project Principal Investigator Affiliation
Dissecting intestinal fibrogenic diseases by a newly developed 4D disease model system Toshiro Sato Keio University
Study of the regulatory mechanisms of cell-cell interaction underlying liver remodeling in NASH for the development of innovative therapeutic and diagnostic procedure Minoru Tanaka National Center for Global Health and Medicine
Elucidation of the pathophysiology of tissue remodeling fibrosis in the airway; towards the development of a new strategy for treating fibrotic diseases Toshinori Nakayama Chiba University
Stem cell system-based four dimensional ocular tissue remodeling in homeostatic and pathological states Kohji Nishida Osaka University
Comprehensive study of resilience control by interaction between the nervous system and the biological system Toshihide Yamashita Osaka University

※For this FY, in order to further improve the quality of project evaluations and help internationalize the R&D environment, AMED introduced AMED reviewers, researchers affiliated with overseas research institutions, to participate in the ex-ante evaluation process for the unit-type (AMED-CREST) project in the “Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms” R&D area.

Solo-type (PRIME)

Project Principal Investigator Affiliation
Study on the roles and mechanisms of adaptive remodeling of the intrahepatic biliary epithelial tissue that supports liver regeneration Tohru Itoh The University of Tokyo
Elucidation of neuronal signal-regulated cell proliferation for tissue adaptation and repair Junta Imai Tohoku University
Study of the central nervous system regeneration by regulating glial scar Seiji Okada Kyushu University
Study of the cellular and cell adhesion molecule mechanisms underlying peripheral nerve axon regeneration Ken Kadoya Hokkaido University
4D multi-scale imaging study sheds light on the tissue remodeling mechanism Junichi Kikuta Osaka University
Investigation of a resilient system for organogenesis during development Asako Shindo Nagoya University
The cellular and molecular basis of lymphoid tissue remodeling by adrenergic nerves Kazuhiro Suzuki Osaka University
Study on the mechanism of inflammatory memory in intestinal regeneration Koji Taniguchi Keio University
Study of endothelial stem cell and vascular homeostasis Hisamichi Naito Osaka University
Organism-level single-cell 4D dynamics in cardiac stress response Seitaro Nomura The University of Tokyo

R&D Area: Clarification of the mechanisms of individual’s functional impairment over the entire life course
Functional Impairment)

Unit-type (AMED-CREST)

Project Principal Investigator Affiliation
Molecular basis of time-related deterioration of mitochondrial function by mtDNA mutation Naotada Ishihara Osaka University
Study on life-long and cross-generation effects of epigenetic memories Hiroyuki Takeda The University of Tokyo
Individual's functional impairment caused by changes in sleep quality: its mechanism & intervention by manipulating sleep architecture Yu Hayashi University of Tsukuba
Biological dysfunction related to T cell senescence, exhaustion, and rejuvenation Akihiko Yoshimura Keio University

Solo-type (PRIME)

Project Principal Investigator Affiliation
Revealing and treating of stress-experience related body dysfunction Kentaro Abe Tohoku University
Understanding the mechanism of maternal epigenetic inheritance of metabolic disorders Azusa Inoue RIKEN
Roles of mitophagy in prevention of hypofunction in whole body Tomotake Kanki Niigata University
Elucidation of mechanisms how social environment regulates the functional impairment Akiko Koto National Institute of Advanced Industrial Science and Technology
Comprehensive analysis of ageing-related decreases in mental-body functions Takuya Sasaki The University of Tokyo
Elucidating the cellular and molecular mechanisms of epithelial stem cell aging Aiko Nishimura (Sada) University of Tsukuba
Study of the mechanistic contribution of defects in amino acid-response systems to aging Masamitsu Fukuyama The University of Tokyo
Age-associated changes in the neural plasticity gene expression profile Sakiko Honjoh University of Tsukuba
Elucidation of mechanism of decreased brain function for regulation of social behavior caused by
disturbed homeostasis of gut ecosystem
Michio Miyajima RIKEN
Understanding of molecular mechanism underlying age-related changes in hematopoiesis based on biology of long-term hematopoietic stem cell Masanori Miyanishi RIKEN

R&D Area: Understanding the interactions and symbiosis between the microbiome and the host organism, leading to an understanding of the mechanisms of disease onset

Unit-type (AMED-CREST)

Project Principal Investigator Affiliation
The mechanism of liver diseases involved in gut-liver axis-mediated gut microbial components and metabolites. Naoko Ohtani Osaka City University
Exploring the molecular mechanisms of the systemic changes caused by the oral microbial dysbiosis in association with periodontal disease. Shinya Murakami Osaka University
Study of microbiota-mediated modulation of neuroinflammation, neurodegeneration and neural
Takashi Yamamura National Center of Neurology and Psychiatry

Solo-type (PRIME)

Project Principal Investigator Affiliation
Mucosal immunity developed by microbe-host interaction through D-amino acids and its
pathological role in the immunological diseases
Jumpei Sasabe Keio University
Comprehensive analysis of microbiome by single cell glycomics Hiroaki Tateno National Institute of Advanced Industrial Science and Technology
The occurrence and control of diabetes and obesity: exploring the multidimensional interaction
between host, antagonist bacteria, and protagonist viruses
Hideyuki Tamaki National Institute of Advanced Industrial Science and Technology
Mechanism for acceleration of T cell senescence and transformation by intestinal flora Hiroko Nakatsukasa Keio University
Elucidation of inhibitory receptor-microbiome interaction in health and disease Kouyuki Hirayasu Kanazawa University
Study of mechanism of pancreatic cancer initiation based on the interaction between microbial flora and host Akihisa Fukuda Kyoto University
Understanding of immunity and metabolism network through nutrient-specific intestinal microbial control and bacterial metabolites Shifo Fujisaka University of Toyama
Unraveling the anti-inflammatory mechanisms of human 2 Bacteroides species and their application for treating chronic inflammatory diseases Tomoya Yamashita Kobe University

Selection Process Schedules and Related Data

Solicitation Period

2018.4.10 Tue - 2018.5.29 Tue Noon (Japan standard time)

Interview Schedule
(Interview Selection Meeting)

R&D Area: Tissue Adaptation and Repair
Unit-type (AMED-CREST): 2018.8.13 Mon
Solo-type (PRIME): 2018.8.15 Wed, 2018.8.16 Thu

R&D Area: Functional Impairment
Unit-type (AMED-CREST): 2018.8.10 Fri
Solo-type (PRIME): 2018.8.13 Mon, 2018.8.14 Tue

R&A Area: Microbiome
Unit-type (AMED-CREST): 2018.9.2 Sun
Solo-type (PRIME): 2018.8.6 Mon, 2018.8.7 Tue


Last updated 10/01/18