Calls for Proposals AMED selected R&D projects to adopt for the FY 2018 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME)
Outline
| Status of Grants/Funding Opportunities | Awarded projects |
|---|---|
| R&D phase | Basic Study |
| Key Fields | Other programs(1st) |
| Contact |
|
Adoption contents
AS a result of scrupulous deliberation conducted by a Project Evaluation Panel, Japan Agency for Medical Research and Development (AMED) selected the R&D projects to adopt for the FY 2018 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME) as follows:
R&D Area: Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms
(Tissue Adaptation and Repair)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Dissecting intestinal fibrogenic diseases by a newly developed 4D disease model system | Toshiro Sato | Keio University |
| Study of the regulatory mechanisms of cell-cell interaction underlying liver remodeling in NASH for the development of innovative therapeutic and diagnostic procedure | Minoru Tanaka | National Center for Global Health and Medicine |
| Elucidation of the pathophysiology of tissue remodeling fibrosis in the airway; towards the development of a new strategy for treating fibrotic diseases | Toshinori Nakayama | Chiba University |
| Stem cell system-based four dimensional ocular tissue remodeling in homeostatic and pathological states | Kohji Nishida | Osaka University |
| Comprehensive study of resilience control by interaction between the nervous system and the biological system | Toshihide Yamashita | Osaka University |
※For this FY, in order to further improve the quality of project evaluations and help internationalize the R&D environment, AMED introduced AMED reviewers, researchers affiliated with overseas research institutions, to participate in the ex-ante evaluation process for the unit-type (AMED-CREST) project in the “Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms” R&D area.
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Study on the roles and mechanisms of adaptive remodeling of the intrahepatic biliary epithelial tissue that supports liver regeneration | Tohru Itoh | The University of Tokyo |
| Elucidation of neuronal signal-regulated cell proliferation for tissue adaptation and repair | Junta Imai | Tohoku University |
| Study of the central nervous system regeneration by regulating glial scar | Seiji Okada | Kyushu University |
| Study of the cellular and cell adhesion molecule mechanisms underlying peripheral nerve axon regeneration | Ken Kadoya | Hokkaido University |
| 4D multi-scale imaging study sheds light on the tissue remodeling mechanism | Junichi Kikuta | Osaka University |
| Investigation of a resilient system for organogenesis during development | Asako Shindo | Nagoya University |
| The cellular and molecular basis of lymphoid tissue remodeling by adrenergic nerves | Kazuhiro Suzuki | Osaka University |
| Study on the mechanism of inflammatory memory in intestinal regeneration | Koji Taniguchi | Keio University |
| Study of endothelial stem cell and vascular homeostasis | Hisamichi Naito | Osaka University |
| Organism-level single-cell 4D dynamics in cardiac stress response | Seitaro Nomura | The University of Tokyo |
R&D Area: Clarification of the mechanisms of individual’s functional impairment over the entire life course
(Functional Impairment)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Molecular basis of time-related deterioration of mitochondrial function by mtDNA mutation | Naotada Ishihara | Osaka University |
| Study on life-long and cross-generation effects of epigenetic memories | Hiroyuki Takeda | The University of Tokyo |
| Individual's functional impairment caused by changes in sleep quality: its mechanism & intervention by manipulating sleep architecture | Yu Hayashi | University of Tsukuba |
| Biological dysfunction related to T cell senescence, exhaustion, and rejuvenation | Akihiko Yoshimura | Keio University |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Revealing and treating of stress-experience related body dysfunction | Kentaro Abe | Tohoku University |
| Understanding the mechanism of maternal epigenetic inheritance of metabolic disorders | Azusa Inoue | RIKEN |
| Roles of mitophagy in prevention of hypofunction in whole body | Tomotake Kanki | Niigata University |
| Elucidation of mechanisms how social environment regulates the functional impairment | Akiko Koto | National Institute of Advanced Industrial Science and Technology |
| Comprehensive analysis of ageing-related decreases in mental-body functions | Takuya Sasaki | The University of Tokyo |
| Elucidating the cellular and molecular mechanisms of epithelial stem cell aging | Aiko Nishimura (Sada) | University of Tsukuba |
| Study of the mechanistic contribution of defects in amino acid-response systems to aging | Masamitsu Fukuyama | The University of Tokyo |
| Age-associated changes in the neural plasticity gene expression profile | Sakiko Honjoh | University of Tsukuba |
| Elucidation of mechanism of decreased brain function for regulation of social behavior caused by disturbed homeostasis of gut ecosystem |
Michio Miyajima | RIKEN |
| Understanding of molecular mechanism underlying age-related changes in hematopoiesis based on biology of long-term hematopoietic stem cell | Masanori Miyanishi | RIKEN |
R&D Area: Understanding the interactions and symbiosis between the microbiome and the host organism, leading to an understanding of the mechanisms of disease onset
(Microbiome)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| The mechanism of liver diseases involved in gut-liver axis-mediated gut microbial components and metabolites. | Naoko Ohtani | Osaka City University |
| Exploring the molecular mechanisms of the systemic changes caused by the oral microbial dysbiosis in association with periodontal disease. | Shinya Murakami | Osaka University |
| Study of microbiota-mediated modulation of neuroinflammation, neurodegeneration and neural development |
Takashi Yamamura | National Center of Neurology and Psychiatry |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Mucosal immunity developed by microbe-host interaction through D-amino acids and its pathological role in the immunological diseases |
Jumpei Sasabe | Keio University |
| Comprehensive analysis of microbiome by single cell glycomics | Hiroaki Tateno | National Institute of Advanced Industrial Science and Technology |
| The occurrence and control of diabetes and obesity: exploring the multidimensional interaction between host, antagonist bacteria, and protagonist viruses |
Hideyuki Tamaki | National Institute of Advanced Industrial Science and Technology |
| Mechanism for acceleration of T cell senescence and transformation by intestinal flora | Hiroko Nakatsukasa | Keio University |
| Elucidation of inhibitory receptor-microbiome interaction in health and disease | Kouyuki Hirayasu | Kanazawa University |
| Study of mechanism of pancreatic cancer initiation based on the interaction between microbial flora and host | Akihisa Fukuda | Kyoto University |
| Understanding of immunity and metabolism network through nutrient-specific intestinal microbial control and bacterial metabolites | Shifo Fujisaka | University of Toyama |
| Unraveling the anti-inflammatory mechanisms of human 2 Bacteroides species and their application for treating chronic inflammatory diseases | Tomoya Yamashita | Kobe University |
Selection Process Schedules and Related Data
|
Solicitation Period |
2018.4.10 Tue - 2018.5.29 Tue Noon (Japan standard time) |
|---|---|
|
Interview Schedule |
R&D Area: Tissue Adaptation and Repair R&D Area: Functional Impairment R&A Area: Microbiome |
10/01/18
Last updated 10/01/18