Calls for Proposals AMED selected R&D projects to adopt for the FY 2019 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME)
Outline
| Status of Grants/Funding Opportunities | Awarded projects |
|---|---|
| R&D phase | Basic Study |
| Key Fields | Other programs(1st) |
| Contact |
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Adoption contents
AS a result of scrupulous deliberation conducted by a Project Evaluation Panel, Japan Agency for Medical Research and Development (AMED) selected the R&D projects to adopt for the FY 2019 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME) as follows:
R&D Area: Understanding of the biological phenomena and responses at the early life stages to improve the quality of health and medical care
(Early Life Stage)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Elucidation of the mechanisms underlying human placental development and design of a placenta-on-a-chip platform | Takahiro Arima | Tohoku University |
| Elucidating cellular and molecular mechanisms of Tfh2 response in allergy in human infants and toddlers | Hideki Ueno | Kyoto University |
| Innovative imaging platform for elucidating pathophysiology of neurodevelopmental disorders | Shigeo Okabe | The University of Tokyo |
| Regulation of embryonic neural stem cells and its relation to postnatal brain development and autism spectrum disorder | Yukiko Gotoh | The University of Tokyo |
| Molecular basis of fetomaternal immune cross-talk controlling homeostasis and disease susceptibility | Yoshinori Fukui | Kyushu University |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Clarification of neuronal network maturation in early life stages | Aya Ito-Ishida | Keio University |
| Developing treatment for abnormal emotional circuits in early life stress model | Akira Uematsu | The University of Tokyo |
| Molecular and neural mechanism of polyphenism responding to light | Misako Okumura | Hiroshima University |
| Study of mechanisms that environmental factors result in developmental disorders | Ken-ichiro Kubo | Keio University |
| Molecular evolutional study reveals the pathogenesis of maternal and child diseases caused by hypoxemia during pregnancy | Nobuaki Takahashi | Kyoto University |
| Understanding human-specific developmental mechanism of the cerebral cortex at the early life stages | Ikuo K. Suzuki | The University of Tokyo |
| Study of intestinal immune tolerance induced by activated Innate Lymphoid Cells | Shinichiro Sawa | Kyushu University |
| Comprehensive study of CHD8-mediated chromatin remodeling on the neurogenesis underlying the onset of ASD | Masaaki Nishiyama | Kanazawa University |
| Is epigenome transgenerationally inherited or not? | Sumiyo Morita | Gunma University |
| Study of the establishment of DNA methylation during primate germ cell development | Toshiaki Watanabe |
Central Institute for Experimental Animals
|
R&D Area: Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms
(Tissue Adaptation and Repair)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Adaptation and repair of skin barrier via multi-cellular interactions | Kenji Kabashima | Kyoto University |
| Neuronal migration: strategies for adaptation and endogenous repair in the injured brain | Kazunobu Sawamoto | Nagoya City University |
| Discovery of tissue repairing immune cells for the development of therapeutic strategy | Hiroshi Takayanagi | The University of Tokyo |
| Identification of cellular and molecular constituents in unique microenvironments regulating tissue damage and repair to prevent chronic kidney disease |
Motoko Yanagita | Kyoto University |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Study of how thermal stress induces beige fat and aging effects on beige fat induction | Kenji Ikeda | Tokyo Medical and Dental University |
| Elucidation of neural repair mechanism by immune cells in the brain injury | Minako Ito | Keio University |
| Elucidation of cell interaction mechanism in suppression of chronic kidney disease progression through nervous and immune systems | Tsuyoshi Inoue | The University of Tokyo |
| Study of the epithelial repair mechanism by the new bioactive peptide | Yukako Oda | Kyoto University |
| Correlation network analysis of neural differentiation in disease iPS cells | Fumi Kano | Tokyo Institute of Technology |
| Study on the crosstalk between stromal cells and immune cells in intestinal homeostasis | Hisako Kayama | Osaka University |
| Regulatory mechanism segregating blood and lymphatic vascular systems | Yoshiaki Kubota | Keio University |
| Exploring and exploiting regulatory T cell-dependent mechanisms of tissue homeostasis | Shohei Hori | The University of Tokyo |
| Removal repair of pre-cancerous cells by spatiotemporally sensing suboptimal cells | Takeshi Maruyama | Waseda University |
| Restoration of regenerative system in the aged central nervous system | Rieko Muramatsu | National Center of Neurology and Psychiatry |
※In order to further improve the quality of project evaluations and help internationalize the R&D environment, AMED introduced AMED reviewers, researchers affiliated with overseas research institutions, to participate in the ex-ante evaluation process for the unit-type (AMED-CREST) project in the "Understanding of the biological phenomena and responses at the early life stages to improve the quality of health and medical care" R&D area and “Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms” R&D area.
R&D Area: Clarification of the mechanisms of individual’s functional impairment over the entire life course
(Functional Impairment)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Study of the aged ribosome and reinforcing ribosome function for the extension of a healthy life | Toshifumi Inada | Tohoku University |
| Research on altered tissue functions caused by clonal expansion and remodeling of apparently normal tissues related to normal aging or exposure to chronic inflammation and other lifestyles | Seishi Ogawa | Kyoto University |
| Investigation of the mechanisms underlying age-associated accumulation of senescent cells | Tohru Minamino | Niigata University |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation |
|---|---|---|
| Comprehensive identification of enhancers in developmental and aging process of in vivo neurons | Yusuke Kishi | The University of Tokyo |
| Study of age-dependent mechanosensory response decline by whole life-course, whole brain imaging technology | Takuma Sugi | Shiga University of Medical Science |
| Clarification of the heterogeneity of cellular senescence in functional impairment | Akiko Takahashi | Japanese Foundation for Cancer Research |
| Mechanism of memory impairment through age related metabolic change | Ayako Tonoki | Chiba University |
| Investigating mechanisms of rejuvenation in basal metazoans and their potential applications | Yuichiro Nakajima | Tohoku University |
| Effect of aging on time-restricted feeding in common marmoset, a non-human primate | Megumi Hatori | Keio University |
| Understanding the mechanism of individual’s functional impairment mediated by age-associated changes in osteocyte-derived osteokines | Mikihito Hayashi | Tokyo Medical and Dental University |
| Individual’s functional impairment and age-related disorders in organs by cytosolic dsDNA of mitochondrial origin | Hideaki Matsui | Niigata University |
| Elucidation of lifespan extension mechanism by S-adenosyl-L-methionine metabolism | Masaki Mizunuma | Hiroshima University |
| Study of age-related formation of super-enhancers and 3D genome dynamics in adaptive lymphocyte development throughout the whole life | Masaki Miyazaki | Kyoto University |
Selection Process Schedules and Related Data
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Solicitation Period |
2019.4.9 Tue - 2019.5.28 Tue Noon (Japan standard time) |
|---|---|
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Interview Schedule |
R&D Area: Early Life Stage R&D Area: Tissue Adaptation and Repair R&A Area: Functional Impairment |
09/26/19
Last updated 09/26/19