News Releases & Research Results Regeneration of renal tissue from multiple renal progenitor cells separately differentiated from human iPS cells

The results of research and development led by graduate student Hiraku Tsujimoto, former graduate student Tomoko Kasahara, former graduate student Shin-ichi Sueda, and Professor Kenji Osafune et al. of the Center for iPS Cell Research and Application (CiRA), Kyoto University.

• Major renal progenitor cells, "metanephric nephron progenitor cells" and "ureteric buds," were successfully differentiated from cultured human iPS cells.
• Also, human renal tissue with nephron (*)-like tissue with glomeruli and renal tubules connected to the collecting tubes was successfully generated for the first time on a culture dish.
  * Tissue responsible for urine production through hemofiltration, the main function of the kidneys. This tissue is composed of a structure for hemofiltration from a mass of blood capillaries called the glomerulus and tubules connected to the structure.
• The results of this R&D should provide new findings in the developmental biology of the human kidney, elucidate the pathogenesis of kidney diseases, and promote research on the regenerative medicine of the kidneys.

This R&D project was conducted with the support of the Research Center Network for Realization of Regenerative Medicine by AMED.

The results were published online in Cell Reports on April 8.

Tsujimoto H., et al. A modular differentiation system maps multiple human kidney lineages from pluripotent stem cells Cell Reports
DOI：10.7554/eLife.45145.001