News Releases & Research Results A method of generating iPS cell-derived liver buds for regenerative medicine - Improved functionality and stability for application to regenerative medicine -

The results of the collaborative research and development project conducted by Special Contract Professor Hideki Taniguchi and Visiting Associate Professor Keisuke Sekine of the Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, Ajinomoto Co., Inc., and the Institute of Medical Science, the University of Tokyo.

• An optimal method for inducing differentiation of three types of cells (hepatic, vascular endothelial, and mesenchymal cells), required for the generation of human iPS cell-derived liver buds, from human iPS cells and culturing the liver buds and a differentiation-inducing supplement (StemFit^® For Differentiation) for clinical use, which meets the standards for biological raw materials, was successfully developed.
• The results of this R&D project should improve safety, stability, and functionality in the generation of human iPS cell-derived liver buds.

This program was conducted with the support of the Research Center Network for Realization of Regenerative Medicine by AMED.

The results were published in Scientific Reports on October 21.

Sekine K., et al. Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media Scientific Reports
DOI: 10.1038/s41598-020-73908-1