News Releases & Research Results Elucidation of the mechanism of SINEUP that increases protein synthesis - Future application to nucleic acid drugs -

The results of international collaborative research conducted by Part-time Researcher Naoko Toki (Doctoral Course Student of the Graduate School of Medical Life Science, Yokohama City University), Special Fixed Term Contract Researcher Hazuki Takahashi (Visiting Researcher), and Team Leader Piero Carninci (Visiting Professor) of the Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences.

• Functional non-coding RNA, SINEUP, discovered as an antisense RNA that promotes protein synthesis, was demonstrated to move intracellularly with a SINEUP-binding protein and act on a translation initiation complex, thereby promoting the translation of target messenger RNA (mRNA).
• The results of this research should facilitate the elucidation of the intracellular behaviors of SINEUP, which is potentially applicable to gene therapy for diseases caused by haploinsufficiency, and improve the productivity of antibody drugs, thereby promoting drug development.

This project was conducted with the support of the Basic Science and Platform Technology Program for Innovative Biological Medicine by AMED.

The results were published online in the scientific journal Nucleic Acids Research on November 2.

Toki N., et al. SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies Nucleic Acids Research
DOI: 10.1093/nar/gkaa814