Calls for Proposals FY 2020 Awarded Projects under Advanced Research & Development Programs for Medical Innovation (AMED-CREST, PRIME)
Outline
| Status of Grants/Funding Opportunities | Awarded projects |
|---|---|
| R&D phase | Basic Study |
| Key Fields | Innovation and Clinical Research Center Project |
| Contact |
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Adoption contents
AS a result of scrupulous deliberation conducted by a Project Evaluation Panel , Japan Agency for Medical Research and Development (AMED) selected the R&D projects to adopt for the FY 2020 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME) as follows:
R&D Area: Understanding proteostasis and discovering innovative medical applications
(Proteostasis)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Protein aggregation and translation: yin and yang of diseased neurons | IWASAKI Shintaro | RIKEN | Chief Scientist |
| Study of mitochondrial proteostasis controlled by protein trafficking | ENDO Toshiya | Kyoto Sangyo University | Professor |
| Cytosolic Glycobiology – Toward comprehensive understanding of the cellular homeostasis | SUZUKI Tadashi | RIKEN | Chief Scientist |
| Study on organelle homeostasis by post-translational modifications | MATSUDA Noriyuki | Tokyo Metropolitan Institute of Medical Science | Project Leader |
| Study on understanding of the molecular mechanisms of tissue-specific unfolded protein responses for radical cure of human chronic diseases | MORI Kazutoshi | Kyoto University | Professor |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Phase-separation-initiated proteolysis by degraders | ARIMOTO Hirokazu | Tohoku University | Professor |
| The quality control mechanisms of nascent organellar proteins – Molecular basis for organellostasis and development of therapeutic strategies– |
IZAWA Toshiaki | Tohoku University | Assistant Professor |
| Understanding of cell-type-specific proteostasis of ribosome and elucidation of novel disease development mechanism | IWASAKI Mio | Kyoto University | Assistant Professor |
| Development of ultra-sensitive quantitative glycome analysis method and elucidation of spatial glycostasis in tissue microenvironment and its medical application | KAWAI Takayuki | RIKEN | Research Scientist |
| Proteostatic regulation for maintaining the function of adult neural stem cells | KOBAYASHI Taeko | Kyoto University | Assistant Professor |
| Basic study toward diagnosis and treatment of mental disorder using disease-related molecule, polySia-NCAM | SATO Chihiro | Nagoya University | Professor |
| Study of cellular proteostasis dynamics by imaging or manipuration of proteasome activity | HAMAZAKI Jun | Tokyo University | Assistant professor |
| Mechanism of autophagy driven by liquid-liquid phase separation | FUJIOKA Yuko | Microbial Chemistry Research Foundation | Researcher |
| Study for physiological regulation and cancer metastasis through modification with glycerol phosphate as a glycosylation termination factor of dystroglycan | YAGI Hirokazu | Nagoya City University | Assistant Professor |
R&D Area: Understanding of the biological phenomena and responses at the early life stages to improve the quality of health and medical care
(Early Life Stage)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Identification of the mechanisms of epigenetic fragility and strategy to prevent AYA cancers | USHIJIMA Toshikazu | National Cancer Center | Chief |
| Elucidation of the molecular basis of environmental memory from early life that prevents lifestyle diseases | SAKAI Juro | Tohoku University | Professor |
| Elucidation of common mechanistic principle for environmental change-induced neuropsychiatric disorders and development of a therapeutic strategy using completely noninvasive cell replacement | NAKASHIMA Kinichi | Kyushu University | Professor |
| Elucidation of metabolic and immune imprinting by prenatal exposure to maternal gut environmental factors | HASE Koji | Keio University | Professor |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Regulatory mechanism of longevity through developmental environment | OBATA Fumiaki | The University of Tokyo | Lecturer |
| Development of a robust computational platform for data-driven epigenome analysis | NAKATO Ryuichiro | The University of Tokyo | Lecturer |
| A new foundation for post-implantation developmental biology in primate | NAKAMURA Tomonori | Kyoto University | Assistant professor |
| Study of the contribution of mechanosensory neurons to establishing proper breathing pattern in mammalian newborns | NONOMURA Keiko | National Institute for Basic Biology | Assistant professor |
| Validation of the causal relationship between early-life myelination in the prefrontal cortex and social behavior | MAKINODAN Manabu | Nara Medical University | Associate Professor |
| Understanding of normal brain development and the CNS pathologies through early life stages of the CNS immune cells | MASUDA Takahiro | Kyushu University | Assistant professor |
| Study of maternal-effect anemia caused by defective ribosome quality control | MISHIMA Yuichiro | Kyoto Sangyo University | Associate Professor |
| Tracing and manipulation of maternal-to-fetal/infant essential fatty acid transmission to understand molecular basis of mental development | YANAGIDA Keisuke | National Center for Global Health and Medicine | Senior Research Fellow |
| Understanding molecular mechanisms of post-weaning environmental effects on adaptative winter survival strategies | YAMAGUCHI Yoshifumi | Hokkaido University | Professor |
| Study of environmental factor-induced diversity in disease phenotype | YOSHIDA Keisuke |
RIKEN
|
Research & Development Researcher |
R&D Area: Understanding of pathophysiological processes and discovery of medical technology seeds through spatiotemporal research of tissue adaptation and repair mechanisms
(Tissue Adaptation and Repair)
Unit-type (AMED-CREST)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Achieving sustainable reconstruction of damaged neural network toward complete recovery in stroke and dementia | SHICHITA Takashi | Tokyo Metropolitan Institute of Medical Science | Project Leader |
| Metabolic reprogramming driving hematological aging | TAKUBO Keiyo | National Cencer for Global Health and Medicine Research Institute | Project Director |
| Mechanism of endocrine dysregulation in hepatic inflammation and fibrosis using patientderived organoids | TAKEBE Takanori | Tokyo Medical and Dental University | Professor |
| New mechanisms of tissue adaptation and repair based on disease-associated lipid metabolism and their applications to novel medical seeds | MURAKAMI Makoto | The University of Tokyo | Professor |
Solo-type (PRIME)
| Project | Principal Investigator | Affiliation | |
|---|---|---|---|
| Spatiotemporal-functional analysis of the enteric nervous system in tissue remodeling | ISHIGAME Harumichi | RIKEN | Senior Research Associate |
| Clarifying and targeting integrated network of hematopoiesis under age-related stress | INOUE Daichi | Foundation for Biomedical Research and Innovation at Kobe | Group Leader |
| Mechanisms of skeletal muscle regeneration mediated by increased macrophage diversity | OISHI Yumiko | Nippon Medical School | Professor |
| Enteric mesenchymal-neural circuit for the mucosal regeneration and fibrogenesis | KURASHIMA Yosuke | Chiba University | Associate Professor |
| Study of the mechanism of lung repair in interstitial lung diseases by temporal cell-cell interaction network analysis | SHICHINO Shigeyuki | Tokyo University of Science | Assistant Professor |
| Spatiotemporal effects of a novel signaling molecule, bicarbonate, in neurovascular unit reconstruction | JO-WATANABE Airi | Juntendo University | Assistant Professor |
| Analysis of sparse and hidden tissue remodeling regions indicated by active astrocytes | SUSAKI Etsuo A. | The University of Tokyo | Associate Professor |
| The roles of oxygen environment on the pathogenesis of cardiac fibrosis | TAKEDA Norihiko | Jichi Medical University | Professor |
| Modeling and studying cholestatic liver diseases using a novel hepato-biliary organoid system | TANIMIZU Naoki | Sapporo Medical University | Associate Professor |
| A challenge to reveal and regulate multi-cellular networks that remove abnormal cells and maintain tissue homeostasis | MOROISHI Toshiro | Kumamoto University | Professor |
※In order to further improve the quality of project evaluations and help internationalize the R&D environment, AMED introduced AMED reviewers, researchers affiliated with overseas research institutions, to participate in the ex-ante evaluation process for the unit-type (AMED-CREST) project.
Selection Process Schedules and Related Data
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Solicitation Period |
2020.3.24 Tue - 2020.5.12 Tue Noon (Japan standard time) |
|---|---|
|
Interview Schedule |
R&D Area: Proteostasis R&D Area: Early Life Stage R&A Area: Tissue Adaptation and Repair |
| Proteostasis | Early Life Stage | Tissue Adaptation and Repair |
||||
|---|---|---|---|---|---|---|
| AMED-CREST | PRIME | AMED-CREST | PRIME | AMED-CREST | PRIME | |
| Number of applicants recieved | 41 | 96 | 39 | 98 | 39 | 146 |
| Number of proposals interviewed | 10 | 17 | 9 | 24 | 9 | 20 |
| Number of proposals selected for funding | 5 | 9 | 4 | 10 | 4 | 10 |
09/28/20
Last updated 09/28/20