Calls for Proposals FY 2023 Advanced Research and Development Programs for Medical Innovation (AMED-CREST, PRIME)

Change log

30th May, 2023
"Interview schedule" has been corrected. [R&D area (AMED-CREST): Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system]

18th May, 2023
“Public invitation briefing” has been updated. [R&D area: Elucidation of mechanisms for stress responses to disease development]

12th May, 2023
"Public offering content", "Interview Schedule", "Public invitation briefing", "Proposal Documents", and "Application Guidelines" have been updated.

Outline

Status of Grants/Funding Opportunities Grants/Funding Opportunities
R&D Phase Basic Study
Key Fields Project for Seeds Development and Research Base, Cancer, Life style disease (Diabetes, Hypertension etc.), Neurological and Psychiatric disorders, Aging and Dementia, Intractable disease/Rare disease, Child health and development, Infectious disease, other
Submission Deadline 05/30/23 Tue Noon (Japan standard time) No exceptions for delay
Contact
Division of Innovative Research and Development, Department of Innovation and Clinical Research Center
E-mail: kenkyuk-kobo “AT”amed.go.jp (Please replace “AT” with “@”)
Remarks:
Please contact us by e-mail using the above contact information.

Public offering content

Elucidation of mechanisms for stress responses to disease development

Program Supervisor (PS): ISO Hiroyasu, Director of Institute for Global Health Policy Research (iGHP), National Center for Global Health and Medicine

Program Officer (PO): ICHIJO Hidenori, Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Program Officer (PO): SEKITANI Tsuyoshi, Professor, SANKEN, Osaka University

In this R&D area, the goal is to develop a scientific understanding of stress responses at the individual level and the mechanisms leading to disease onset. Further goals are identifying new stress markers that provide objective indicators of biological responses to stress exposure, and developing new measuring devices or signal processing technologies that allow the capture of biological information in response to stress.

Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system

Program Supervisor (PS): MOCHIZUKI Naoki, Director General, National Cerebral and Cardiovascular Center

Program Officer (PO): FUKAMIZU Akiyoshi, Director, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba

Program Officer (PO): YASUTOMO Koji, Professor, Graduate School of Medical Sciences, Tokushima University

This R&D area aims to clarify the biology of the basic mechanisms involved in aging and to develop medical approaches mediated via these mechanisms. The programs will include research that uses the most up-to-date analytical technologies (genetic, imaging, omics analysis) and can be progressed from analysis in model organisms through to applied research. This R&D area will be implemented by AMED and JST together, with the two organizations liaising closely to promote the research.

Immunological memory: Understanding, regulation and medical innovation

Program Supervisor (PS): NAKAYAMA Toshinori, President, Chiba University

Program Officer (PO): TAKEDA Kiyoshi, Professor, Graduate School of Medicine, Osaka University

We welcome R&D proposals that will contribute to: (1) a new and fundamental understanding of how human immunological memory is formed, maintained, and lost; (2) clarification of novel mechanisms of cancer immunity mediated by human immunological memory; (3) an understanding of human immunological memory against infectious diseases in societies living with COVID-19 and after the COVID-19 pandemic; and (4) development of novel methods controlling allergic and autoimmune diseases, based on an understanding of human immunological memory.

Integrated understanding of multi-sensing networks and elucidation of their control mechanisms leading to the innovation of medical technologies

Program Supervisor (PS): NAGAI Ryozo, President, Jichi Medical University

Program Officer (PO): TAKEUCHI Shoji, Professor, Graduate School of Information Science and Technology, the University of Tokyo

Program Officer (PO): NISHIDA Kohji, Professor, Graduate School of Medicine, Osaka University

This R&D area aims to develop an integrated understanding of multi-sensory systems that includes sensory systems and peripheral nerve networks, and create innovative seeds for medical technologies based on an understanding of control mechanisms. This R&D area is implemented by AMED and JST together, with the two organizations liaising closely to promote the research. 

Generating research infrastructure and novel technologies for anti-infective drug and vaccine discovery

Program Supervisor (PS): DOI Yohei, Professor, Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine / Professor, Division of Infectious Diseases, University of Pittsburgh School of Medicine

Program Officer (PO): MATSUURA Yoshiharu, Director, Center for Infectious Diseases Education and Research (CiDER) and SA Professor, Laboratory of Virus Control, Research Institute for Microbial Diseases (RIMD), Osaka University

We call for research proposals in the following specific areas: (1) develop new approaches, including drug discovery modalities, that will contribute to the prevention and treatment of infectious diseases; (2) optimize existing modalities for infectious disease drug discovery; and (3) develop technology platforms that will accelerate infectious disease drug discovery and generate innovative preventive and therapeutic agents against infectious diseases.

Solicitation Period

04/11/23 Tue - 05/30/23 Tue Noon (Japan standard time) No exceptions for delay

Interview Schedule

Interview Selection Meeting

Please confirm the details as indicated below. When a hearing review is conducted, the PI will be notified by e-mail no later than one week before the interview day.
Please understand we cannot answer any questions regarding the progress status of the selection process, including the eligibility of the individual project for the hearing review.
※Interview reviews will be conducted over the Internet.

Research and Development Area AMED-CREST PRIME
Elucidation of mechanisms for stress responses to disease development August 1st August 3th
August 4th
Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system August 10th
August 9th
August 3th
August 4th
Immunological memory: Understanding, regulation and medical innovation August 2nd We are not offering it.
Integrated understanding of multi-sensing networks and elucidation of their control mechanisms leading to the innovation of medical technologies

August 9th

August 7th
August 8th

Generating research infrastructure and novel technologies for anti-infective drug and vaccine discovery August 1st We are not offering it.

Public invitation briefing

Recording of Public invitation briefing

Contents Briefing materials
Elucidation of mechanisms for stress responses to disease development Download
Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system Download
Immunological memory: Understanding, regulation and medical innovation Download
Integrated understanding of multi-sensing networks and elucidation of their control mechanisms leading to the innovation of medical technologies Download
Generating research infrastructure and novel technologies for anti-infective drug and vaccine discovery Download

How to Apply

Proposal Documents

AMED-CREST

Mandatory or Optional Documents Remarks
Mandatory (Form C1)R&D Proposal  
Mandatory

(Appendix C1)Summary of Proposal
(Japanese/English)

 

Mandatory
when 
applicable

(Appendix C2)Human Whole Genome Sequence Analysis Protocol Form Appendix C2 must be submitted in Excel format, if your research plan includes whole human genome analysis and/or whole exome analysis.

PRIME

Mandatory or Optional Documents Remarks
Mandatory (Form P1)R&D Proposal  
Mandatory (Appendix P1)Summary of Proposal
(Japanese/English)
 

Mandatory
when 
applicable

(Appendix P2)Human Whole Genome Sequence Analysis Protocol Form Appendix P2 must be submitted in Excel format, if your research plan includes whole human genome analysis and/or whole exome analysis.

Mandatory
when 
applicable
(Only for the R&D area "Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system")

Additional form for duplicate application
(Japanese Only)

When making a duplicate application for the AMED PRIME and the JST PRESTO, download the "Additional form for duplicate application" at the JST PRESTO website and submit it to JST (no need to submit it to AMED).
※Please refer to Chapters 2 and 5 in the Application Guidelines and the JST PRESTO website for more details. 

Reference

04/11/23

Last updated 05/30/23