News Releases & Research Results Production of a large amount of tissue that serves as a source of the renal collecting duct

News Releases & Research Results


The results of research and development conducted by Assistant Professor Shin-ichi Mae, Researcher Makoto Ryosaka, and Professor Kenji Osafune of the Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University.

The key results of R&D are as follows:

  • A method of producing ureteric bud tissue (organoids), a kidney progenitor tissue, from human iPS cells was invented. Furthermore, the tip cells removed from ureteric bud organoids were successfully expanded to regenerate ureteric bud organoids.
  • The pathological conditions of polycystic dysplastic kidney*, a congenital renal disease, were successfully reproduced using the technology.
    *Congenital disease with a large number of cysts (a liquid-containing a bag-shaped structure) formed in the kidneys. This disease is generally caused by renal failure due to abnormal differentiation of metanephric mesenchyme and ureteric bud. It occurs in about 1 in 4,300 births, a high incidence among congenital renal urinary tract abnormalities.
  • The results this R&D project of should facilitate the elucidation of the mechanism in which the ureteric buds repeat branching and differentiate into the collecting ducts and the establishment of a disease model of congenital renal disease.

This program was conducted with the support of the Research Center Network for Realization of Regenerative Medicine by AMED.

The results of this R&D project were published in Cell Reports on July 29.


Mae S., et al. Expansion of human iPSC-derived ureteric bud organoids with repeated branching potential Cell Reports


Last updated 07/29/20