Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation（AMED-CREST）

[Research and Development Objective] Creation of basic medical technologies for the prevention, diagnosis and treatment of cancer, arteriosclerotic diseases, and autoimmune disorders by the elucidation of the mechanisms underlying chronic inflammation

The purpose of this R&D area is to elucidate the mechanisms through which inflammation becomes chronic, and to create basic technologies for the early detection, control, resolution, and reparation of chronic inflammation.

More specifically, this involves research aimed at: (1) identifying factors that induce and maintain the chronicity of inflammation by determining failure mechanisms of inflammation control; (2) clarifying the mechanisms through which specific diseases (including cancer, degenerative neurological disorders, and arteriosclerotic diseases) develop as a result of chronic inflammation, and to create basic technologies to control them; and (3) creating basic technologies that allow for the early detection and quantitative assessment of chronic inflammation. This not only involves established basic and clinical research, but also emphasizes research that sufficiently sublimes evidence-based findings for understanding higher order inflammation control mechanisms, and leads to the development of new preemptive basic medical technologies.

2010

Program Supervisor (PS)

MIYASAKA Masayuki

R&D Area Advisors

INAGAKI Nobuya

Professor, Kyoto University

IMAMURA Takeshi

Professor, Ehime University

UEMATSU Satoshi

Professor, Chiba University

OHSUGI Yoshiyuki

Chairman&CEO, Ohsugi BioPharma Consulting Co., Ltd.

KOH Shosei

Director, Shironishi Hospital; Professor Emeritus, Shinshu University

TAKATSU Kiyoshi

Director, Toyama Prefectural Institute of Pharmaceutical Research

TAKAYANAGI Hiroshi

Professor, The University of Tokyo

YAMAUCHI-TAKIHARA Keiko

Professor, Osaka University

MURAKAMI Masaaki

Director, Hokkaido University

YOKOMIZO Takehiko

Professor, Juntendo University

YOSHIMURA Akihiko

Professor, Keio University