Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation(AMED-CREST)

Promotion and support of this Research and Development (R&D) Area was transferred from the Japan Science and Technology Agency (JST) as of April 1, 2015. The original English texts were based on those provided by the courtesy of JST.

Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases (Completed)

[Strategic Objective] Development of medical technology using immunoregulation to overcome allergic and autoimmune diseases including pollinosis

Outline of the Research & Development (R&D) Area

This R&D area aims to improve prevention, diagnosis, and treatment of human immunological diseases, centered on allergic and autoimmune diseases, and includes research for development of basic technologies for improvement of appropriate functioning of the immune system.

Diseases centered on allergic responses and autoimmune systems vary from those that may lower the quality of life (QOL) of patients to those leading to death in serious cases. Deepened understanding of the immune mechanism and control of such diseases at levels of molecules, cells, organs, and tissues will be evolved into understanding of a higher-level control immune network system at individual levels, leading to clinical application.

Specific examples of research projects include immunoregulatory mechanisms by regulatory cells, construction mechanisms of the mucous membrane immune system, autoimmune system, acquired immune system, and natural immune system and their control, etiological mechanisms of autoimmune and allergic diseases, immune and infection control mechanisms, development of drugs and vaccines against diseases and measurement of their effects, establishment of methods for diagnosis and treatment of diseases, and so forth.

Year the Area adopted

2010

Management and Evaluation Framework

Program Supervisor (PS)

SUGAMURA Kazuo
Chief Director, Miyagi Prefectural Hospital Organization

R&D Area Advisors

SAITO Takashi
Group Director, RIKEN Yokohama Institute
SAKAGUCHI Shimon
Professor, Osaka University
SHIBUYA Kazuko
Associate Professor, University of Tsukuba
TAKATSU Kiyoshi
Director, Toyama Prefectual institute for Pharmaceutical Research
TOKUHISA Takeshi
President, Chiba University
NOSE Masato
Professor Emeritus, Ehime University
HANAI Nobuo
President, Kyowa Hakko Kirin Co., LTD.
MIYASAKA Nobuyuki
Professor, Tokyo Medical and Dental University
YAMAMOTO Kazuhiko
Professor, The University of Tokyo

Brochure

Last updated 2020.2.26