Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation（AMED-CREST, PRIME）

[Research and Development Objective] Investigations into life phenomena and the discovery of medical technology seeds based on spatiotemporal insights into biological tissue adaptation and repair mechanisms

The goal of this R&D area is to significantly accelerate the discovery of technology seeds that contribute to health and medical care by deepening the spatiotemporal understanding of biological tissue adaptation and repair mechanisms.

The body maintains its functions through tissue adaptation and repair against various types of tissue injury or excessive stress. It remains to be elucidated how the organism responds to the damages from the inside and outside of the living body, what types of cells in the tissues are involved in adaptation and repair, and what kind of interactions proceed during adaptation and repair. When the regulatory mechanisms for the tissue adaptation and repair become dysfunctional, tissue homeostasis is broken down, thereby eventually leading to the onset of serious diseases. These processes are also not fully understood.

The aim of this R&D area is the elucidation of mechanisms of tissue adaptation and repair, their maintenance and broken-down. We will develop new technologies to obtain greater spatiotemporal insights, and will discover the seeds for preventive, diagnostic, and therapeutic technologies.

2018

Program Supervisor (PS)

YOSHIMURA Akihiko

Professor, Keio University School of Mediceine

Program Officer (PO)

YOKOMIZO Takehiko

Professor, Juntendo University School of Medicine

R&D Area Advisors

ISHII Masaru

Professor, Graduate School of Medicine, Osaka University

IMAI Yumiko

Project Leader, National Institutes of Biomedical Innovation, Health and Nutrition

KATAGIRI Hideki

Professor, Tohoku University Graduate School of Medicine

TAKAKURA Nobuyuki

Professor, Research Institute for Microbial Diseases, Osaka University

TAKAHASHI Masahide

Director of Academic Program, Designated Professor,

Director of International Center for Cell and Gene Therapy, Fujita Health University

TAMURA Kouichi

Executive Officer, Research, Head of Kobe Research Institute, Healios K.K.

FURUYASHIKI Tomoyuki

Professor, Graduate School of Medicine, Kobe University

MATSUSHIMA Kouji

Professor, Research Institute for Biomedical Sciences, Tokyo University of Science

MINAMINO Tohru

Professor, Juntendo University Graduate School of Medicine

MIYAJIMA Atsushi

Project Professor, Institute of Quantitative Biosciences, The University of Tokyo