Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation(AMED-CREST, PRIME)

Understanding of Pathophysiological Processes and Discovery of Medical Technology Seeds through Spatiotemporal Research of Tissue Adaptation and Repair Mechanisms

[Research and Development Objective] Investigations into life phenomena and the discovery of medical technology seeds based on spatiotemporal insights into biological tissue adaptation and repair mechanisms

Outline of the Research & Development (R&D) Area

The goal of this R&D area is to significantly accelerate the discovery of technology seeds that contribute to health and medical care by deepening the spatiotemporal understanding of biological tissue adaptation and repair mechanisms.

The body maintains its functions through tissue adaptation and repair against various types of tissue injury or excessive stress. It remains to be elucidated how the organism responds to the damages from the inside and outside of the living body, what types of cells in the tissues are involved in adaptation and repair, and what kind of interactions proceed during adaptation and repair. When the regulatory mechanisms for the tissue adaptation and repair become dysfunctional, tissue homeostasis is broken down, thereby eventually leading to the onset of serious diseases. These processes are also not fully understood.

The aim of this R&D area is the elucidation of mechanisms of tissue adaptation and repair, their maintenance and broken-down. We will develop new technologies to obtain greater spatiotemporal insights, and will discover the seeds for preventive, diagnostic, and therapeutic technologies.

Year the Area adopted

2018

Management and Evaluation Framework

Program Supervisor (PS)

YOSHIMURA Akihiko
Professor, Keio University School of Mediceine

Program Officer (PO)

YOKOMIZO Takehiko
Professor, Juntendo University School of Medicine

R&D Area Advisors

ISHII Masaru
Professor, Graduate School of Medicine, Osaka University
IMAI Yumiko
Project Leader, National Institutes of Biomedical Innovation, Health and Nutrition
KATAGIRI Hideki
Professor, Tohoku University Graduate School of Medicine
TAKAKURA Nobuyuki
Professor, Research Institute for Microbial Diseases, Osaka University
TAKAHASHI Masahide
Professor, Nagoya University Graduate School of Medicine
TAMURA Kouichi
Executive Officer, Research, Head of Kobe Research Institute, Healios K.K.
FURUYASHIKI Tomoyuki
Professor, Graduate School of Medicine, Kobe University
MATSUSHIMA Kouji
Professor, Research Institute for Biomedical Sciences, Tokyo University of Science
MINAMINO Tohru
Professor, Niigata University Graduate School of Medical and Dental Sciences
MIYAJIMA Atsushi
Project Professor, Institute of Quantitative Biosciences, The University of Tokyo

Brochure

Last updated 2021.3.19