Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation（AMED-CREST, PRIME）

[Research and Development Objective] Elucidation of the mechanisms relating to changes in biological robustness associated with aging and control of age-related diseases

In the “ageing” research area, basic studies that aim at clarification of fundamental mechanisms underlying aging and researches that tackle age-related diseases by inhibiting the process that contribute to accelerating aging are encouraged to reduce the number of patients suffering from those diseases. The studies and researches follow the previous project on aging and bridge the fundamental molecular mechanism and clinical application. To facilitate understanding of aging, researchers will use model organisms to investigate the genetic, cell biological and inter-tissue/organ regulation that determine aging. In addition to these challenges, environmental cues that regulate or affect the speed of aging are also examined.
Methods to control aging will also be developed. Following findings of new principles of aging and mechanisms involved in the impairment of robustness and resilience that intrinsically function against aging, the researchers will identify the biomarker of aging and find novel therapy against accelerated aging.

2022

Program Supervisor (PS)

MOCHIZUKI Naoki

Director General, National Cerebral and Cardiovascular Center Research
Institute Medic

Program Officer (PO)

 FUKAMIZU Akiyoshi

Professor and Director, Life Science Center for Survival Dynamics, Tsukuba
Advanced Research Alliance (TARA), University of Tsukuba

 YASUTOMO Koji

Professor, Graduate School of Medicine, Tokushima University

R&D Area Advisors

AIBA Atsu

Professor, Graduate School of Medicine, The University of Tokyo

IMAI Toshio

Professor, Graduate School of Medicine,Kobe University

KATAGIRI Toyomasa

Professor, Institute for Enzyme Research, Tokushima University

SAYA Hideyuki

Professor/Director, Fujita Cancer Center, Fujita Health University

TSUDA Makoto

Professor, Department of Pharmaceutical Health Care
and Sciences, Kyushu University

NISHINA Hiroshi

Professor/Director, Medical Research Institute, Department
of Developmental and Regenerative Biology,
Tokyo Medical and Dental University

FUKAMI Kiyoko

Professor Emeritus, Department of Medical Science, Tokyo University
of Pharmacy and Life Sciences

FUKAMI Maki

Deputy Director, Research Institute, National Center
for Child Health and Development

MUKOYAMA Masashi

Professor, Faculty of Life Sciences, Kumamoto University

YONEDA Yoshihiro

Director, The Research Foundation for Microbial Diseases of Osaka University