Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation(AMED-CREST)

Promotion and support of this Research and Development (R&D) Area was transferred from the Japan Science and Technology Agency (JST) as of April 1, 2015. The original English texts were based on those provided by the courtesy of JST.

Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies (Completed)

[Research and Development Objective] Clarification of the Control Mechanisms of Neural Circuit Operation and its Formation

Outline of the Research & Development (R&D) Area

This R&D area aims to elucidate the molecular and cellular mechanisms of the generation, development, and regeneration of the brain neural network; to investigate how neural networks composed of a variety of elements in individual brain areas work and express their specific functions; and to clarify how the brain works as a coherent system by integrating the activities of these local networks. On the basis of such research, it also aims to create technologies for controlling the process of formation and activities of the brain neural network.

Specific approaches may include elucidation of the molecular mechanisms of development, differentiation, regeneration, target recognition, and migration of neurons (components of neural networks) and glial cells that significantly influence neural network formation and functions; elucidation of the mode of neural network activities by combining new technologies, such as visualization of specific neurons with the use of specific expression molecules and fluorescent proteins, simultaneous recording of activities of many neurons, and local stimulation with a caged compound; research to clarify the relationship of higher order brain functions with synaptic events through the combination of research at the network and system levels in model animals and research on the regulatory mechanism of synaptic transmission at the molecular and cellular levels; elucidation of the mechanism of neural network reorganization at the critical period or after brain damage; and creation of technologies for intervention in its process.

Year the Area adopted


Management and Evaluation Framework

Program Supervisor (PS)

Professor, Takasaki University of Health and Welfare

R&D Area Advisors

ISA Tadashi
Professor, Kyoto University
OHMORI Harunori
Professor, Kyoto University
OKABE Shigeo
Professor, The University of Tokyo
Professor, Tamagawa University
KUDO Yoshihisa
Professor Emeritus, Tokyo University of Pharmacy and Life Sciences
KUBA Kenji
Professor Emeritus, Nagoya University
TSUDA Ichiro
Professor, Hokkaido University
Professor Emeritus, Niigata University Fellow, Brain Research Institute
Professor, Hokkaido University
WADA Keiji
Director, National Center of Neurology and Psychiatry


Last updated 2020.2.26