Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation（AMED-CREST）

[Research and Development Objective] Creating fundamental technologies for advanced medicine through generation and regulation of stem cells, based on cellular reprogramming

The objective of this R&D area is to establish fundamental technologies contributing to advanced medicine through the development of cellular reprogramming technology. Remarkable progress has been made in this field recently, especially the generation of iPS cells. The research objectives include the advancement and simplification of this technology, the elucidation of pathological mechanisms through the development of model cells, the formulation of new therapy strategies, and novel methods for the early discovery of diseases.

Specifically, included is research on cellular reprogramming and differentiation mechanisms using genomics, chromosome structure and epigenetic analysis; research on gene transfer regulation; high-throughput screening of reprogramming-inducing compounds; and research using iPS cells generated from patients with congenital diseases for the elucidation of pathological mechanisms. Moreover, the research also covers an area that may lead to the pioneering of new therapy methods and preventive medicine through the integration of stem cell research and pathological studies.

2010

Program Supervisor (PS)

SUDA Toshio

Director, International Research Center for Medical Sciences (IRCMS), Kumamoto University

R&D Area Advisors

SASAKI Hiroyuki

Professor, Kyushu University

SHIOMI Mikiko

Professor, The University of Tokyo

TAKAI Yoshimi

Professor, Kobe University

TAKEUCHI Masatoshi

Team Leader, RIKEN

NAKANO Toru

Professor, Osaka University

HAYASHIZAKI Yoshihide

Director, RIKEN

MIYAZONO Kohei

Professor, The University of Tokyo