Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation(AMED-CREST)

Promotion and support of this Research and Development (R&D) Area was transferred from the Japan Science and Technology Agency (JST) as of April 1, 2015. The original English texts were based on those provided by the courtesy of JST.

Fundamental Technologies for Medicine Concerning the Generation and Regulation of Induced Pluripotent Stem (iPS) Cells (Completed)

[Research and Development Objective] Creating fundamental technologies for advanced medicine through generation and regulation of stem cells, based on cellular reprogramming

Outline of the Research & Development (R&D) Area

The objective of this R&D area is to establish fundamental technologies contributing to advanced medicine through the development of cellular reprogramming technology. Remarkable progress has been made in this field recently, especially the generation of iPS cells. The research objectives include the advancement and simplification of this technology, the elucidation of pathological mechanisms through the development of model cells, the formulation of new therapy strategies, and novel methods for the early discovery of diseases.

Specifically, included is research on cellular reprogramming and differentiation mechanisms using genomics, chromosome structure and epigenetic analysis; research on gene transfer regulation; high-throughput screening of reprogramming-inducing compounds; and research using iPS cells generated from patients with congenital diseases for the elucidation of pathological mechanisms. Moreover, the research also covers an area that may lead to the pioneering of new therapy methods and preventive medicine through the integration of stem cell research and pathological studies.

Year the Area adopted


Management and Evaluation Framework

Program Supervisor (PS)

SUDA Toshio
Director, International Research Center for Medical Sciences (IRCMS), Kumamoto University

R&D Area Advisors

SASAKI Hiroyuki
Professor, Kyushu University
Professor, The University of Tokyo
TAKAI Yoshimi
Professor, Kobe University
TAKEUCHI Masatoshi
Team Leader, RIKEN
Professor, Osaka University
Director, RIKEN
Professor, The University of Tokyo


Last updated 2020.2.26