Division of Regenerative Medicine The Program for Technological Innovation of Regenerative Medicine
Outline
| Key Fields | Japan Regenerative Medicine Project |
|---|---|
| R&D phase | Basic Study, Applied Study |
| Contact |
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This program implements objective-achievement-type basic research, based on original ideas that advance the development of the field of stem cells and regenerative medicine. The main purpose of this program is to develop seeds of next-generation innovative medicine; therefore, emphasis is on research that will be expected high international competitiveness, research based on innovative and creative ideas, and also research that contributes to technological innovation. It also encourages collaboration with researchers in other countries and different fields. The funding lasts for up to three years, and around 15-25 million yen/year will be awarded. All the accepted proposals in FY2016, 2018, 2019 and 2020 are listed below.
Research Projects
List of Terminated Projects
| Adoption Fiscal Year (Research Period) |
Title of Research and Development | Principal Investigator | Position | Affiliation |
|---|---|---|---|---|
| 2016 (3 yrs) |
Reconstitution of functional kidney tissues by manipulation of differentiation processes | NISHINAKAMURA Ryuichi | Professor | Institute of Molecular Embryology and Genetics, Kumamoto University |
| 2016 (3 yrs) |
Direct reprogramming for heart regeneration | IEDA Masaki | Professor | Faculty of Medicine, University of Tsukuba |
| 2016 (3 yrs) |
Analysis of boundary epigenome networks that regulate Naïve/tumorigenic/differentiation property of primed human iPS cells | NISHINO Koichiro |
Associate Professor | Graduate School of Medicine and Veterinary Medicine/ Faculty of Agriculture, University of Miyazaki |
| 2016 (3 yrs) |
The use of pluripotent stem cells to model the mechanism of pancreatic beta cell maturation | KUME Shoen | Professor | School of Life Science and Technology, Tokyo Institute of Technology |
| 2016 (3 yrs) |
Study on function and control technology of cancer/non-cancer stem cells as assemblers | AOI Takashi | Professor | Graduate School of Science, Technology and Innovation, Kobe University |
| 2016 (3 yrs) |
Organ regeneration by local reactivation of developmental field | SATOH Akira | Associate Professor | Research Core for Interdisciplinary Sciences, Okayama University |
| 2016 (3 yrs) |
Establishment and application of liver fibrosis model using human induced pluripotent stem cell-derived liver cells | KIDO Taketomo | Research Associate | Institute for Quantitative Biosciences, The University of Tokyo |
| 2016 (3 yrs) |
Scalable generation of human iPS cell-derived lung epithelial cells and their application to disease modeling | GOTOH Shimpei | Associate Professor | Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University |
| 2016 (3 yrs) |
Neuro-regenerative therapy by human injury/ischemia-induced neural stem cells | TAKAGI Toshinori | Research Associate | Department of Neurosurgery, Hyogo College of Medicine |
| 2016 (3 yrs) |
Development of muscle regenerative therapy based on functional heterogeneity and hierarchy in muscle stem cell population | ONO Yusuke | Associate Professor | Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, Kumamoto University |
| 2016 (3 yrs) |
Elucidation of metabolic program and development of metabolic manipulation technology of hematopoietic stem cells | TAKUBO Keiyo | Project Director | Research Institute, National Center for Global Health and Medicine |
| 2016 (3 yrs) |
Reprogramming of cardiomyocytes from immature to mature status | UOSAKI Hideki | Lecturer | Center for Molecular Medicine, Division of Regenerative Medicine, Jichi Medical University |
| 2016 (3 yrs) |
Development of local manipulation tool of human pluripotent stem cells | OHGUSHI Masatoshi | Associate Professor | Institute for Frontier Life and Medical Sciences, Kyoto University |
List of Progressing Projects
| Adoption Fiscal Year (Research Period) |
Title of Research and Development | Principal Investigator | Position | Affiliation |
|---|---|---|---|---|
| 2018 (3 yrs) |
Development of novel optical methods to regulate differentiation of neural stem cells | IMAYOSHI Itaru | Professor | The Graduate School of Biostudies, Kyoto University |
| 2018 (3 yrs) |
Elucidation of cell properties in human trophoblast stem cell for the purpose of regenerative medicine | OKAE Hiroaki | Associate Professor | Department of Informative Genetics, Tohoku University School of Medicine |
| 2018 (3 yrs) |
Targeted organ generation using a novel method for making chimeras | KOBAYASHI Toshihiro | Assistant Professor | Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences |
| 2018 (3 yrs) |
Method for diagnosis of neural and neurodegenerative disorders using iPSC | SUGAWARA Tohru | Researcher | Department of Reproductive Biology and Cellular Medicine, National Center for Child Health and Development |
| 2018 (3 yrs) |
Development of selection and isolation methods for lineage-restricted mesenchymal progenitors derived from human pluripotent stem cells | TAKARADA Takeshi | Professor | Department of Regenerative Science, Okayama University |
| 2018 (3 yrs) |
Induction of fibrosis into endodermal organoids coupled by mechano-screen platform | TAKEBE Takanori | Professor | Research and Industry-University Alliance Organization, Tokyo Medical and Dental University |
| 2018 (3 yrs) |
Dynamics and regulation of higher order chromatin structure during heart development and cardiomyocyte differentiation | NOMURA Seitaro | Assistant Professor | Department of cardiology, The university of Tokyo hospital |
| 2018 (3 yrs) |
Development of All HLA Homozygous Pluripotent Stem Cells and Their Evaluation of Pan-transplantabllity | HAYASHI Yohei | Team Leader | RIKEN BioResource Research Center |
| 2018 (3 yrs) |
Development of a prediction system for rejection of regenerated graft and the a method for the prevention of graft rejection | MASUDA Kyoko | Assistant Professor | Institute for Frontier Life and Medical Sciences, Kyoto University |
| 2018 (3 yrs) |
Development of a reprogramming technology to produce adult-tissue derived highly plastic intestinal epithelial organoids | YUI Shiro | Associate Professor | Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University |
| 2019 (3 yrs) |
Direct reprogramming and cardiac regeneration for heart failure | IEDA Masaki | Professor | Faculty of Medicine, University of Tsukuba |
| 2019 (3 yrs) |
Development of treatment for cutaneous ulcers by embryonization of tissues | KURITA Masakazu | Assistant Professor | Department of Plastic, Reconstructive and Aesthetic surgery, The University of Tokyo Hospital |
| 2019 (3 yrs) |
Elucidation of pluripotent stem cell maintenance mechanism based on regulation of RNA functional structures and cell fate control | SAITO Hirohide | Professor | Center for iPS Research and Application, Kyoto University |
| 2019 (3 yrs) |
Strategies for promotion of neuronal migration and regeneration | SAWAMOTO Kazunobu | Professor | Department of Developmental and Regenerative Biology, Graduate School of Medical Science, Nagoya City University |
| 2019 (3 yrs) |
The study for the development of an innovative regenerative therapy for liver diseases using induced hepatic progenitor cells | SUZUKI Atsushi | Professor | Medical Institute of Bioregulation, Kyushu University |
| 2019 (3 yrs) |
To clarify the principle of human peri-implantation development using in vitro 3D gastruloids | TAKASHIMA Yasuhiro | Lecturer | Center for iPS Research and Application, Kyoto University |
| 2019 (3 yrs) |
Development of a positional memory-based therapy for muscle diseases | ONO Yusuke | Associate Professor | Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, Kumamoto University |
| 2019 (3 yrs) |
Generation of lung tissue simulators by human pluripotent stem cells | GOTOH Shimpei | Associate Professor | Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University |
| 2019 (3 yrs) |
Understanding and prediction model for neuron development from human pluripotent stem cell based on transcription/epigenetic diversity and sex difference | FUKUDA Atsushi |
Lecturer | Institute of Innovative Science and Technology, Medical Division, Tokai University |
| 2019 (3 yrs) |
Development of brain regeneration by the use of vascularized human brain organoid | MATSUI Takeshi | Lecturer |
Faculty of Medicine, Shimane University |
| 2019 (3 yrs) |
Development of novel methods to protect stem cells from functional impairment and cancer development using the longest-lived rodent | MIURA Kyoko | Associate Professor | Priority Organization for Innovation and Excellence / Faculty of Life Sciences, Kumamoto University |
| 2019 (3 yrs) |
Study of selective survival of gonocytes for the production of qualified Spermatogonial Stem Cell | YAMANAKA Soichiro | Associate Professor | Graduate School of Science, The University of Tokyo |
| Adoption Fiscal Year (Research Period) |
Title of Research and Development | Principal Investigator | Position | Affiliation |
|---|---|---|---|---|
| 2020 (3 yrs) |
Spatiotemporal programs regulating hematopoietic stem cell maturation | TAKUBO Keiyo | Project Director | Department of Stem Cell Biology, National Center for Global Health and Medicine Research Institute |
| 2020 (3 yrs) |
Generation of T cells with diverse reactivity by regenerating thymic function | HAMAZAKI Yoko | Professor | Center for iPS Cell Research and Application, Kyoto University Laboratory of Immunobiology, Graduate school of medicine, Kyoto University |
| 2020 (3 yrs) |
Realization of human cardiomyocyte proliferation – A key for cardiac regeneration - |
YAMASHITA Jun K. | Professor | Center for iPS Cell Research and Application, Kyoto University |
| 2020 (3 yrs) |
Modeling Skeletal Muscle Tissue Regeneration with Stem Cell-Macrophage Interaction | KOIKE Hiroyuki | Assistant Professor | Department of Biochemistry & Molecular Biology Nippon Medical School |
| 2020 (3 yrs) |
Development of novel safe medical device to promote regeneration of injured peripheral nerve by human iPSC-derived neuron and bioabsorbable material | SHIBATA Shinsuke | Professor | Division of histology, Graduate School of Medicine and Dentistry, Niigata University |
| 2020 (3 yrs) |
3D tissue reconstruction with hierarchical vascular networks | TADOKORO Tomomi | Assistant Professor | Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University |
| 2020 (3 yrs) |
Development of designer niche cell that governs tissue microenvironment | TODA Satoshi | Assistant Professor | Nano Life Science Institute, Kanazawa University |
| 2020 (3 yrs) |
Development of human kidney regeneration technology from iPS cell-derived progenitor cells using mouse nephrogenic niche | YAMANAKA Shuichiro | Research Associate | Division of Nephrology and Hypertension, Department of internal medicine, The Jikei University School of Medicine |
| 2020 (3 yrs) |
3D Human Axial Development In Vitro: using novel human in vitro somitogenesis models to study birth defects with patient-relevant iPS cell lines | ALEV Cantas | Associate Professor | Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University |
| 2020 (3 yrs) |
Generating platelets in vitro for the clinic: optimisation and added clinical efficacy | ETO Koji | Professor | Center for iPS Cell Research and Application, Kyoto University |
| 2020 (3 yrs) |
Improving haematopoietic reconstitution in blood stem cell transplantation procedures through the regulation of stem cells and their niches | TAKIZAWA Hitoshi | Professor | International Research Center for Medical Sciences, Kumamoto University |
| 2020 (3 yrs) |
Elucidating and modulating macrophage and stem cell responses to bioactive nanoclays for bone regeneration | TABATA Yasuhiko | Professor | Laboratory of Biomaterials, Institute for Frontier Life and Medical Sciences, Kyoto University |
| 2020 (3 yrs) |
Non-invasive monitoring of human pluripotent stem cell differentiation into midbrain dopaminergic neural cells | MORIZANE Asuka | Junior Associate Professor | Clinical application, Center for iPS Cell Research and Application, Kyoto University |
| 2020 (3 yrs) |
Human blood stem cell expansion: Empowering new technology for stem cell medicine | YAMAZAKI Satoshi | Project Associate Professor |
Division of Stem Cell Biology, The Institute of Medical Science, The University of Tokyo |
| 2020 (3 yrs) |
Reprogramming adult human hepatocytes into liver progenitors with unlimited self-renewal, efficient differentiation and transplantation capacities | YUSA Kosuke | Professor | Stem Cell Genetics laboratory, Institute for Frontier Life and Medical Sciences, Kyoto University |
| 2020 (3 yrs) |
Harnessing spermatogonial stem cell flexibility to increase transplantation efficiency | YOSHIDA Shosei | Professor | Division of Germ Cell Biology, National Institute for Basic Biology |
Management
PS（Program Supervisor）
IWAMA Atsushi, M.D., Ph.D., Professor, Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
PO（Program Officer）
AKUTSU Hidenori, M.D., Ph.D., Director, Department of Reproductive Medicine, National Center for Child Health and Development
TOYOSHIMA Fumiko, Ph.D., Professor, Institute for Frontier Life and Medical Sciences, Kyoto University
YAMAMOTO Masaya, Ph.D., Professor, Department of Materials Processing, Graduate School of Engineering, Tohoku University
Last updated 04/12/21