Division of Innovative Research and Development Advanced Research & Development Programs for Medical Innovation(AMED-CREST, PRIME)
Understanding proteostasis and discovering innovative medical applications
[Research and Development Objective]Understanding and medical application of proteostasis
Outline of the Research & Development (R&D) Area
This R&D area aims to clarify the relationship between structure and function based on evidence obtained from biochemical and structural biological approaches, to understand the molecular pathways that cause various diseases, and to discover potential solutions for healthcare or methods to maintain good health.
The R&D is focused on understanding the molecular basis of proteins during the processes that occur between initial protein translation and synthesis to ultimate degradation, and will investigate denaturation, aggregation, and degradation processes that set proteins on a final, irreversible pathway, as well as posttranslational modifications that have irreversible effects on protein function.
Target diseases include, but are not limited to, neurodegenerative disease, mental health disorders, intractable cancers, chronic inflammatory diseases, amyloidosis, fibrosis, rare diseases, infectious diseases, and lifestyle diseases like arteriosclerosis and diabetes, as well as insights into how to avoid aging and maintain a healthy state.As well as researchers involved in the fields of proteins and glycans, we welcome participation by basic science or clinical researchers in structural biology, immunity, metabolism, or nerve systems, as well as researchers from other fields, including analytical chemistry and bioinformatics.
The goal is to make progress in world-class, highly innovative research and development by bringing together and leveraging the strengths of a range of disciplines.
Year the Area adopted
2020
Management and Evaluation Framework
Program Supervisor (PS)
- NAGATA Kazuhiro
- Director General, JT Biohistory Research Hall
Program Officer (PO)
- ENDO Tamao
- Senior Fellow, Tokyo Metropolitan Institute of Gerontology
R&D Area Advisors
- ADACHI Takeshi
- Professor, School of Medicine, National Defense Medical College
- INADA Toshifumi
- Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
- IWAI Kazuhiro
- Dean, Professor, Graduate School of Medicine Kyoto University
- KATO Koichi
- Professor, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences
- KINOSHITA Taroh
- Professor, Research Institute for Microbial Diseases, Osaka University
- SHIMIZU Ritsuko
- Professor, Tohoku University School of Medicine
- SUZUKI Rami
- President and Representative Director Moderna Japan KK
- TANAKA Keiji
- Board Chairperson, Tokyo Metropolitan Institute of Medical Science
- FUJIMOTO Toyoshi
- Research Professor, Juntendo University School of Medicine
- MIYOSHI Eiji
- Professor, Graduate School of Medicine, Osaka University
- YAMADA Hisafumi
- Executive Vice President, Chugai Pharmaceutical Co., LTD.
Brochure
Last updated 04/08/24