Terminated Projects

Key Fields	Basic Research for Medical Innovation, Other programs(1st)
R&D phase	Basic Study, Applied Study, Nonclinical Study/Pre-clinical Study, Clinical Study, Clinical Trials, Post Marketing, Clinical Research, None
Contact	Division of Research Programs, Department of International Strategy TEL: +81-3-6870-2216 E-mail: sicorp”at”amed.go.jp Remarks: ※Replace”at”with @.

Research Area – "Advancing Epigenetic Technologies": The aim is to support Japan- and Canada-based early career researchers develop fruitful international collaborations in the field of epigenetic mechanisms and technologies.
Funding Agency of Canadian Side: Canadian Institutes of Health Research (CIHR)
Duration: FY2020-FY2023

Project Title	Artificial Intelligence based adaptive and interpretable models for analyzing multi-track epigenomic sequential data
Country	Japan	Canada
PI	Dr. YAMANAKA Soichiro	Dr. Ahmed Ashraf
Affiliation	The University of Tokyo	University of Manitoba

Project Title	Single-cell probing of epigenetic memory in immunity
Country	Japan	Canada
PI	Dr.Jay Shin	Dr.David Langlais
Affiliation	RIKEN	McGill University

Project Title	Characterization of the integrative epigenetic and epitranscriptomic landscape of acute myeloid leukemias
Country	Japan	Canada
PI	Dr.YOSHIMI Akihide	Dr.Ly Vu
Affiliation	National Cancer Center Research Institute	Simon Fraser University

Research Area – "Epigenetics of Stem Cells": AMED-CIHR Joint Research Project "The Epigenetics of Stem Cells" is created to promote and expand joint researches on ways to lead to new innovative technologies that could address major challenges in the basic understanding of stem cell activity and function, as well as remove barriers to effective translation of stem cell research for health benefits.
Funding Agency of Canada Side: Canadian Institutes of Health Research (CIHR)
Duration: FY2013～FY2017

Project Title	Epigenetics and stemness in human hematopoiesis and leukemia: a new generation of stem cell targeted regenerative and leukemia therapeutics
Country	Japan	Canada
PI	Dr. Hiromitsu Nakauchi	Dr. John E. Dick
Affiliation	Center for StemCell Biology and RegenerativeMedicine, Institute of Medical Science, University of Tokyo	CanadaResearch Chair in Stem Cell Biology, Ontario Cancer Institute

Project Title	Genetic and epigenetic hierarchies distinguishing pluripotent and trophoblast stem cells
Country	Japan	Canada
PI	Dr. Hitoshi Niwa	Dr. Janet Rossant
Affiliation	Department of Pluripotent Stem Cell Biology, Institute for Molecular Embryology and Genetics, Kumamoto University	Developmental & Stem Cell Biology, The Hospital for Sick Children

Project Title	Directing Cellular Identity to Move Towards Progenitor Cell Therapies
Country	Japan	Canada
PI	Dr. Yasuhiro Yamada	Dr. Andras Nagy
Affiliation	Center for iPS cell Research and Application (CiRA), Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University	Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Ongoing Projects

Research Area – "Cell Therapy - a focus on quality, efficacy and safety": The aims are to: 1) strengthen research collaborations between Japan and Singapore within the field of ”Cell Therapy - a focus on quality, efficacy and safety” ; and 2) achieve world-class scientific results through the development and use of new and innovative technologies which can address the challenges facing the international community in the area of health research in both countries.
Funding Agency of Singapore Side: Agency for Science, Techonology and Research (A*STAR)
Duration: FY2019～FY2022

Project Title	Developing a safe and potentially efficacious piggyBac-based CAR-T cell strategy for virus-related cancers
Country	Japan	Singapore
PI	Dr. SAITO Shoji	Dr. Timothy Wai Ho Shuen
Affiliation	Department of Pediatric, Shinshu University	Division of Medical Oncology, National Cancer Centre Singapore

Project Title	Large-scale Preparation of Hair Follicle Germs using Hydrogel Printing
Country	Japan	Singapore
PI	Dr. KAGEYAMA Tatsuto	Dr. Michinao Hashimoto
Affiliation	Kanagawa Institute of Industrial Science and Technology (KISTEC)	Singapore University of Technology and Design

Project Title	Human stem cell-derived pancreatic beta cells for the treatment of diabetes
Country	Japan	Singapore
PI	Dr. SHIRAKAWA Jun	Dr. Adrian Kee Keong Teo
Affiliation	Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation, Gunma University	A*STAR/NUS Medicine, the Institute of Molecular and Cell Biology (IMCB)

Research Area – "Biological and Molecular Determinants of Human Ageing": The aim are to: 1) strengthen research collaborations between Japan and Singapore within the field of "Biological and Molecular Determinants of Human Ageing"; and 2) achieve world-class scientific results through the development and use of new and innovative technologies which can address the challenges facing the international community in the area of health research in both countries.
Funding Agency of Singapore Side: Agency for Science, Techonology and Research (A*STAR)
Duration: FY2017～FY2020

Project Title	Biological signatures of cardiovascular, musculoskeletal and cognitive ageing in the very old
Country	Japan	Singapore
PI	Dr. ARAI Yasumichi	Dr. Woon-Puay Koh
Affiliation	Keio University School of Medicine	Duke-NUS Medical School

Project Title	Effect of aging of the innate immune system on intracellular system network
Country	Japan	Singapore
PI	Dr. FUJIU Katsuhito	Dr. Xiaomeng Wang
Affiliation	The University of Tokyo	Singapore Eye Research Institute (SERI)

Project Title	Targeting age-associated white matter lesions
Country	Japan	Singapore
PI	Dr. IHARA Masafumi	Dr. Peter Tsun-Hon Wong
Affiliation	National Cerebral and Cardiovascular Center	National University of Singapore

Research Area – "Nanomedicine": The aims are to:
1) Strengthen research collaborations between Japan and Spain within the field of Nanomedicine;
2) Achieve world-class scientific results through the development and use of new and innovative
technologies which can address the challenges facing the international community in the area of
health research in both countries.
Funding Agency of Spain Side: State Research Agency of Spain （AEI）
Duration: FY2018～FY2021

Project Title	Development of phototherapeutic strategies for amyloid-related diseases enabled by a nanoscale view of amyloid photodamage (AMYLIGHT)
Country	Japan	Spain
PI	Dr. SOHMA Youhei	Dr. Cristina Flors
Affiliation	The University of Tokyo	IMDEA Nanociencia

Project Title	Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer (COnCorD)
Country	Japan	Spain
PI	Dr. Sabina Quader	Dr. Rosalía Rodríguez-Rodríguez
Affiliation	Innovation Centre of Nanomedicine (iCONM)	Universidad Internacional de Cataluña

Project Title	Nano-scaffolding for neuronal migration and regeneration (Nano-ReBrain)
Country	Japan	Spain
PI	Dr. KANEKO Naoko	Dr. Vicente Herranz-Pérez
Affiliation	Nagoya City University	Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)

Research Area – "Infectious Diseases": The overarching aim of the UK-Japan collaborative initiative in infectious diseases is to provide bi-lateral support to biomedical and health researchers in the UK and Japan that will allow them to forge lasting collaborations. This initative aims to strengthen existing links or foster new links that add value to research taking place in both countries. This is expected to be achieved by facilitating exchange and catalysing innovative synergy amongst collaborators and is particularly aimed at those who are in the early stages of their careers.
Funding Agency of the UK Side: The UK Medical Research Council（MRC）
Duration: FY2019～FY2022

Project Title	Elucidation of cell-autonomous immunity and host defense against Toxoplasma gondii by interferon-inducible GTPases
Country	Japan	U.K.
PI	Dr. YAMAMOTO Masahiro	Dr. Eva-Maria Frickel
Affiliation	Research Institute for Microbial Diseases, Osaka University	The University of Birmingham

Project Title	Interferon stimulated defences that target Hepatitis B Virus (HBV) and Hepatitis D Virus (HDV)
Country	Japan	U.K.
PI	Dr. WATASHI Koichi	Dr. Sam Wilson
Affiliation	National Institute of Infectious Diseases	MRC University of Glasgow Centre for Virus Research (CVR)

Project Title	Dynamic Imaging in Viral Encephalitis Defines Unique Roles for Chemoattractants
Country	Japan	U.K.
PI	Dr. MIYABE Yoshishige	Dr. Benedict Michael
Affiliation	St. Marianna University School of Medicine	University of Liverpool

Project Title	The HDAC6/USP7 axis in enveloped RNA virus infection
Country	Japan	U.K.
PI	Dr. MIYAKE Yasuyuki	Dr. Yohei Yamauchi
Affiliation	Nagoya University Graduate School of Medicine	University of Bristol School of Cellular and Molecular Medicine

Project Title	A cross-sectional approach to identification & interrogation of adaptive & functional mutations affecting CCHFV replication & pathogenicity in humans
Country	Japan	U.K.
PI	Dr. MORITA Kouichi	Dr. David Allen
Affiliation	Institute of Tropical Medicine, Nagasaki University	London School of Hygiene and Tropical Medicine (LSHTM)

Project Title	Study of the T cell Response During Cryptococcal Meningitis Using New Tools
Country	Japan	U.K.
PI	Dr. KAWAKAMI Kazuyoshi	Dr. Rebecca Drummond
Affiliation	Tohoku University Graduate School of Medicine	University of Birmingham

Project Title	The human T-cell leukaemia virus HTLV-1: transcriptional heterogeneity at the single-cell level
Country	Japan	U.K.
PI	Dr. SATO Yorifumi	Dr. Charles Bangham
Affiliation	Kumamoto University	Imperial College

Project Title	Systematic analysis of persistence mechanisms by high-throughput bar-seq and single cell analyses
Country	Japan	U.K.
PI	Dr.MUTO-FUJITA Ai	Dr.Suzie Hingley-Wilson
Affiliation	RIKEN	University of Surrey

Research Area – "Neuroscience - Computational Connectomics": The aim of the collaborative project is to provide bi-lateral support to biomedical and health researchers in Japan and Germany that will allow them to forge lasting collaborations in the field of neuroscience-computational connectomics.
Funding Agency of German Side: Deutsche Forschungsgemeinschaft e.V (DFG)
Duration: FY2020～FY2023

Project Title	Computational and Physiological Approaches to the Primate Anxiety Connectome
Country	Japan	Germany
PI	Dr. AMEMORI Ken-ichi	Prof. Dr. Peter Dayan
Affiliation	Kyoto University	Max Planck Institute for Biological Cybernetics / University of Tübingen

Project Title	The role of dynamic neural functional coupling in spontaneous thought
Country	Japan	Germany
PI	Dr.Mingbo Cai	Dr.Nicolas Schuck
Affiliation	The University of Tokyo	Max Planck Institute for Human Development

Ongoing Projects

Completed Terminated Projects - International Collaborative Research Program: Strategic International Collaborative Research Program (SICORP)

Outline

SICORP (Canada)

SICORP (Singapore)

SICORP (Spain)

SICORP (UK)

SICORP (Germany)