News Releases & Research Results News Releases & Research Results（2020）
Dec
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12/29/20Significantly increased chimerism of donor cells in a heterologous chimera
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12/23/20Elucidation of the structure of the dopamine receptor involved in schizophrenia - Rapid search and designing of drugs with fewer side effects -
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12/22/20Elucidation of a novel acquired resistance mechanism for immune checkpoint inhibitors via prostaglandin E2 - Application to new immunotherapy -
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12/21/20Identification of novel disease-related gene mutations in inherited bone marrow failure syndrome with hematopoietic insufficiency, mental retardation, and short stature/microcephaly - Proposal of a new disease concept “AMeD syndrome” -
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12/18/20Acceleration of brain mapping research by artificial intelligence (AI) - Improved accuracy and reliability of AI-based brain circuit mapping technology by the Japanese brain science project -
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12/18/20Elucidation of the molecular brain pathology of neuropsychiatric disorders due to 22q11.2 deletion syndrome using iPS cells
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12/17/20Smallest scissors for genome editing - Elucidation of the three-dimensional structure of CRISPR-Cas12f -
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12/17/20Identification of the genes responsible for oocyte morphogenesis - Mass production of egg cytoplasm -
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12/15/20High-speed analysis of small motions of a protein that perceives "heat" and "pain" - Guidelines for the development of new analgesics with fewer side effects -
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12/14/20Elucidation of the hidden diversity of human centromere DNA sequences
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12/08/20Elucidation of the mechanism of generation of "osteoclasts" responsible for bone destruction at single-cell resolution - For the development of novel treatments for bone-destruction diseases such as osteoporosis and rheumatism -
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12/08/20Efficient gene suppression with a DNA/DNA double-stranded oligonucleotide as a candidate for novel nucleic acid drugs - Advances toward the development of therapeutics for intractable disease -
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12/08/20Development of an advanced artificial intelligence technology to find depression using brain networks - Advance toward the clinical application of an effective brain network marker across multiple imaging sites -
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12/08/20Identification of a novel biomarker for selecting liver cancer treatment - Clinical application for predicting malignancy and drug treatment effects -
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12/07/20Development of a supramolecular biosensor for rapid quantitation of a vitamin metabolite
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12/02/20Novel therapeutic target for schizophrenia - Potential usefulness of a nuclear receptor PPARα activator -
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12/02/20Structural analysis of a G protein-coupled prostaglandin receptor, leading to the elucidation of the EP4 activation mechanism - Promising findings for the development of therapeutic methods for ulcerative colitis, acute heart failure, osteoporosis, glomerulonephritis, etc. -
Nov
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11/25/20Early changes in Parkinson's disease, identified using health examination data
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11/25/20Development of chemically - modified microRNA143-3p targeting RAS networks -
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11/24/20Enhanced therapeutic effects of EGFR inhibitors by transdermal administration of tumor-suppressive miRNA-634 - For practical applications of microRNA ointment for squamous cell skin cancer -
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11/24/20Production of glial cells, effective for spinal cord injury, from clinical human iPS cells - Promising cell sources for clinical applications -
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11/24/20Ultra-stable artificial protein retaining its folding ability even with loosened hydrophobic packing
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11/21/20Mechanism of action of a molecule that suppresses intracellular stress response - Drug candidate molecule for suppressing structural changes of a translation initiation factor into an inhibitory form -
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11/20/20Suppression of malignant transformation through the activation of β2 adrenergic receptor signals - For the development of novel oral cancer treatments with few side effects -
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11/13/20Elucidation of the binding mechanism of a cyclic peptide to human serum albumin - Accelerate the discovery of cyclic peptide drugs -
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11/11/20Associations between blood metabolites and genomes - Association analysis between plasma metabolomes and gene polymorphisms for future medical care -
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11/11/20A new mitochondrial function that controls responses to viral infection - Regulation of antiviral responses by sensing intracellular energy status -
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11/11/20Elucidation of brain patterning - A mechanism of distinct formation of the cerebral cortex and the basal ganglia -
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11/10/20Recording of fly’s life cycle events with “DIAMonDS” - Development of a monitoring and detection system for Drosophila individual activities -
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11/05/20One-third of the elderly are potential patients with Parkinson's disease/Lewy body dementia, whose severity is reflected by esophageal lesions
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11/02/20Elucidation of the mechanism of SINEUP that increases protein synthesis - Future application to nucleic acid drugs -
Oct
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10/30/20Development of a new method for decoding viral genes - Discovery of novel viral proteins of HSV and elucidation of the onset mechanism of herpesvirus encephalitis -
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10/30/20Development of a PET imaging agent that facilitates the development of therapeutic drugs for dementia - Promoting pathological analysis, early diagnosis, and new drug development by visualizing tau pathologies in the brain -
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10/30/20Elucidation of the proliferation mechanism of human pancreatic cells - Progress in cell therapies for diabetes -
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10/21/20A method of generating iPS cell-derived liver buds for regenerative medicine - Improved functionality and stability for application to regenerative medicine -
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10/21/20Human hepatic progenitor cells generated by direct reprogramming - Life-saving effects of cell transplantation in a mouse model of acute hepatic failure -
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10/21/20Cancer detection by orderly synthesizing heterogeneous glycan clusters - A new synthetic strategy for cell recognition by mimicking living organisms -
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10/21/20IRAK4 deficiency presenting with anti-NMDAR encephalitis in infancy - Relationship between early-onset anti-NMDAR encephalitis and genetic immune disorders -
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10/20/20A novel neurotransmitter mechanism for regulating mating-induced egg production
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10/20/20Identification of key cells involved in an unknown infection route of human T-cell leukemia virus type 1 - Elucidation of the mechanism of infection through the placenta -
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10/16/20Neural circuits responsible for monitoring others’ actions
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10/14/20Prostaglandin pathway associated with lifestyle-related diseases - Efficacy of aspirin and EP4 antagonist as antimetabolite drug candidates -
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10/13/20Energy dynamic imaging for living kidneys - Renal prognosis based on the energy metabolism of the proximal tubules -
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10/12/20A novel mechanism involved in the pathophysiology of autism spectrum disorder - Promote the establishment of therapeutic strategies and the development of new drugs for autism spectrum disorder -
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10/09/20T cell abnormality characteristic of severe COVID-19
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10/06/20Genome-wide association studies in more than 600,000 individuals reveal the effect of variants on the onset of coronary artery disease
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10/06/20Development of Precision Medicine for Gastrointestinal Cancers: Utility of Liquid Biopsy in Genomic Analysis
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10/02/20A highly accurate method for genome sequence estimation with privacy protection ensured - A novel deep learning-based method -
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10/01/20Personality classification enhances the discrimination capacity of a blood biomarker for depression - Human-mouse cross-validation study -
Sep
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09/30/20Mechanism of Salmonella infectious prevention mediated by short-chain fatty acid binding to a novel receptor protein
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09/30/20Mechanism of gastritis caused by Helicobacter pylori: paving the way for the development of therapeutic modalities other than antibiotic eradication of H. pylori
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09/29/20Novel treatment for patients with heart failure: the effectiveness of cardiac rehabilitation
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09/28/20The successful identification and characterization of in vivo senescent cells
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09/28/20Suppression of the development of hepatocellular carcinoma by selective removal of damaged mitochondria: A rationale for a novel drug discovery strategy targeting dysfunctional mitochondria
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09/17/20Transplantation of CD73-positive cells suppresses pulmonary fibrosis paving the way to the development of a novel therapy through induction of immune tolerance
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09/17/20Depression-related PCSK5 gene, which induces inflammation in the deep brain, discovered in a mouse experiment
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09/16/20Discovery of the molecular and neural mechanisms involved in the refractory manifestations of schizophrenia: Elucidation of a novel function of the schizophrenia-related gene SETD1A
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09/15/20Development and validation of new diagnostic criteria for allergic bronchopulmonary mycosis
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09/14/20Elucidation of the mechanism by which the effects of immunomodulator thalidomide on target proteins are altered through metabolism in the body - Development of drugs with few side effects -
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09/14/20Lipid metabolism disorder in the cerebral white matter of schizophrenia patients - Unknown pathogenesis of schizophrenia -
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09/11/20New findings of Japanese women’s menstrual cycle and basal body temperature by big data analysis – Age-dependent significant changes in menstrual cycle and basal body temperature during the high-temperature phase -
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09/11/20Elucidation of the mechanism by which the foreign DNA sensor cGAS for innate immunity does not respond to autologous chromosomal DNA - A clue to elucidating the causes of diseases such as viral infection protection, autoimmune diseases, cancer, and neurodegenerative diseases -
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09/11/20Discovery of a candidate biomarker for autism spectrum disorder - Biological reclassification of autism spectrum disorder -
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09/08/20Development of a method for selectively removing undifferentiated iPS cells with an anti-obesity drug - Accelerating the realization of regenerative medicine with reduced risks of formation -
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09/04/20Membrane protein PGRMC1 promotes obesity by facilitating lipid accumulation
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09/04/20Activation of muscle stem cells by damaged muscles: Clues for elucidation of the pathogenesis of muscle diseases and the development of drugs for their treatment
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09/03/20Novel circular RNA highly expressed in pancreatic cancer and its application as a biomarker: development of a novel diagnostic marker for pancreatic cancer
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09/02/20Controlling the actions and physical properties of drugs by metal-catalyzed reactions in vivo: a new direction in designing prodrugs
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09/02/20Discovery of a novel model of neural circuitry in basal ganglia involved in motor control: Interaction between direct and indirect pathways
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09/01/20High-precision biomarker predictive of clinical efficacy of immune checkpoint inhibitors (PD-1/PD-L1 inhibitors): precision medicine in immunotherapy
Aug
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08/28/20Extracellular vesicles secreted by HBV-infected cells prevent elimination of HBV in a mouse model of HBV infection.
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08/28/20Efficient induction of cardiomyocytes using a soft scaffold for establishment of a new method for cardiac regeneration
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08/27/20Elucidation of mechanism of central nervous inflammation promoted by gut microorganisms - a novel potential treatment and prevention method for multiple sclerosis
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08/25/20Dysbiosis in the Gut Microbiome Shapes Disease Course in the Different Stages of Multiple Sclerosis - Combination of microbial composition and comprehensive functional gene analyses revealed the key microbial function associated with secondary progressive multiple sclerosis -
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08/25/20Fibroblasts prevent auto-immunity - discovery of novel mechanism of T cell training -
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08/21/20Sex difference in the mechanism of skeletal muscle growth and regeneration - elucidation of functional significance of estrogen receptor β
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08/20/20How does aging cause lifestyle-related diseases? - A novel treatment strategy using autophagy inhibition -
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08/20/20Discovery of a novel mutation involved in the progression of childhood brain tumor: A strategic foundation for personalized treatment for various cancers based on cell type
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08/18/20Unveiling the DNA-binding mechanism of the transcription factor GATA3 which controls cell fate: A clue to elucidate etiologies of breast cancer and other diseases
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08/17/20Development of a method to distinguish between schizophrenia and developmental disorder based on a machine-learning classification using neuroimaging data
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08/17/20Elucidation of the chronic mechanisms of acute kidney injury using Mincle, a sensor for cell death - Development of novel preventive methods for chronic kidney diseases -
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08/17/20Prediction of the risks of depressive symptoms using machine learning - For personalized medicine for mental disorders -
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08/14/20Reinforcement of the pain control system in the brain through simultaneous learning by the brain and AI agents
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08/11/20Development of a novel transplantation model for regenerative medicine - To promote iPS cell-based transplantation medicine -
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08/11/20Identification of potential susceptibility genes for Japanese familial pancreatic cancer - To overcome pancreatic cancer -
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08/07/20Discovery of a common mechanism underlying onset of a group of dementias called the frontotemporal lobar degeneration spectrum diseases
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08/07/20Unbalanced neuronal fate specification associated with psychoses: Insights from research on brain organoids derived from induced pluripotent stem cells
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08/05/20A molecular mechanism underlying the induction of direct hepatic reprogramming: Discovery of a novel mechanism of action of transcription factors
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08/01/20Identification of a risk locus for interstitial lung disease complicating rheumatoid arthritis, as well as its association with chest CT image patterns related to pulmonary fibrosis
Jul
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07/31/20Development of a method to elucidate complex genomic rearrangements using a new technology, long-read sequencer
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07/31/20Are viruses active indoors or outdoors? - Elucidation of the strategy of hepatitis C virus infection in an integrated study of mathematics and experiments -
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07/30/20Association of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages - Elucidation of a biological characteristic of supercentenarians -
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07/29/20Elucidation of the molecular onset mechanism of incurable COPA syndrome - Development of new therapeutic agents for autoimmune/autoinflammatory diseases -
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07/29/20Production of a large amount of tissue that serves as a source of the renal collecting duct
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07/24/20Elucidation of clinical and genetic characteristics of mitochondrial liver disease for the first time in Japanese
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07/23/20Optical biopsy for the immediate diagnosis of cancer without excision - Stereoscopic observation without tissue damage by imaging, followed by AI-based automatic diagnosis -
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07/22/20Identification of a gene mutation strongly associated with the onset of schizophrenia by genome analysis!
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07/22/20Unknown effects of intestinal flora on the spread of systemic inflammation
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07/17/20Relief of phantom pain in hands lost in accidents by training to change brain activities - Novel treatment by a technology to move phantom limbs using brain signals -
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07/15/20Multiomics analysis of HIV-1-infected cells in vivo - Clues for the development of an HIV-1 cure -
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07/11/20Elucidation of the mechanism of cancer progression induced by a factor from vascular endothelial cells in tumor tissues - Development of novel therapies targeting the signals of cancer microenvironment networks -
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07/10/20Development of a novel antibody drug for canine lymphoma - Starting a veterinarian-initiated clinical trial on canine lymphoma -
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07/10/20Large-scale international analysis on the causative gene of severe cardiomyopathy in newborns - Early diagnosis and development of therapies of cardiomyopathy -
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07/08/20Treatment of malignant tumors by “poison control by poisoning” - A novel therapeutic strategy for refractory tumors by reverse thinking -
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07/08/20A cyclic peptide that enhances the anticancer effects of antibody drugs
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07/07/20Development of a drug candidate that specifically acts on a “switch” in the brain - Fast-acting therapy without any side effects for psychiatric and neurological diseases -
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07/03/20Effectiveness of transplantation of skeletal muscle stem cells derived from human induced pluripotent stem cells in muscular dystrophy mouse model
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07/03/20Discovery of the structural change of norovirus particles before infection: A significant advance in the elucidation of the mechanism underlying norovirus infection, which should facilitate the development of novel therapeutic drugs and vaccines
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07/01/20Discovery of a new mode of signal transmission in the brain - Clues for the development and treatment of diseases -
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07/01/20In vivo visualization of an abnormal protein potentially inducing depression in older individuals: opening a path for the treatment and prevention of depression in the elderly
Jun
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06/30/20Identification of a novel protein that prevents the development of autoimmune diseases - The chromatin remodeling factor Chd4 plays a role in self-antigen expression and prevents autoimmune diseases -
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06/30/20Nationwide Survey of Chronic Active EB Virus Infection Based on the New WHO Classification and the New Diagnostic Criteria - Unravelling the Differences between Childhood and Elderly Onset Cases and their Treatments -
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06/26/20Optical manipulation of neurons successfully evoking forelimb movements in monkeys
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06/26/20Launch of an investigator-initiated clinical trial of a medical robot for needle insertion (Zerobot®) developed at Okayama University
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06/26/20Discovery of a new autoantibody as an important cause of recurrent pregnancy loss
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06/25/20To elucidate leukemia development mechanisms particular to the Japanese - Results of utilizing the BioBank Japan database -
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06/25/20New SATREPS Projects for FY 2020 under AMED International Collaborative Research Program
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06/24/20Discovery of specific functions of DNA methyltransferases, DNMT3A and DNMT3B - Contributing to the elucidation of mammalian development and cancer development mechanisms -
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06/23/20Elucidation of the pathology of the novel coronavirus (SARS-CoV-2) infection (COVID-19) / Development of prevention and treatment methods - Usefulness of Syrian hamsters as an animal model for infection
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06/19/20Altered DNA methylation status of a serotonin-related gene in male patients with schizophrenia and bipolar disorder
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06/17/20Discovery of novel genes responsible for developmental disorders with trigonocephaly - New findings leading to the elucidation of the onset mechanism of developmental disorders -
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06/12/20Elucidation of a novel anti-inflammatory mechanism created by the autonomic nervous system - New treatment for vagal infection, cancer, and inflammatory bowel diseases -
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06/10/20Development of gene-targeted antibacterial drugs for selective killing of bacteria - To overcome drug-resistant bacteria -
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06/10/20Launch of CIRCULATE-Japan, a new project for personalized cancer treatment by liquid biopsy - Launch of the world’s largest investigator-initiated international joint trial on invisible cancers -
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06/09/20Elucidation of genetic characteristics associated with disease onset in Japanese people: Genetic mutation screening by genome analysis in 210,000 Japanese individuals
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06/05/20Discovery of a key molecule regulating sperm maturation: A new perspective on the etiology and treatment of infertility
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06/04/20Comprehensive description of the human tissue virome in healthy individuals - “Hidden” associations between the human virome and human health and disease -
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06/03/20Development of a novel therapy for Alport syndrome using an oligonucleotide therapeutic: Remarkable effectiveness confirmed in model animal for refractory inherited kidney disease
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06/02/20Development of a sperm sorting technique that improves the success rate of in vitro fertilization
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06/01/20Elucidation of a novel mechanism underlying inflammatory and malignant diseases caused by human T cell leukemia virus type 1, which is common among the Japanese population
May
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05/27/20Novel drug candidate for polyglutamine (polyQ) diseases, intractable neurodegenerative diseases – Protein structure-stabilizing effects of L-arginine against aggregation
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05/22/20Development of a new functional analysis method for BRCA2 gene variants that increase the risk of hereditary breast and ovarian cancers
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05/21/20Molecular design of Smart Nanomachine® for treating Alzheimer's dementia with a low dose of antibody drug
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05/21/20Fluorescence technology to visualize mitochondrial mitophagy - Contribution to the diagnosis and treatment of Parkinson's disease -
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05/21/20Clinical trial with human ES cells for congenital urea cycle disorder - World's first transplantation of human ES cell-derived hepatocytes into humans!
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05/12/20Identification of new gene regions responsible for type 2 diabetes in an East Asian population
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05/07/20Genetic backgrounds and lifestyle habits predisposing the Japanese population to gastric cancer: Results of a large-scale trans-ethnic genome analysis in patients with gastric cancer
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05/06/20Discovery of a new metabolic enzyme that mobilizes health-beneficial omega-3 fatty acids and suppresses obesity
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05/05/20Discovery of a new function of peroxisomes as suppliers of cholesterol to cilia: Elucidation of the mechanism of the onset of ciliopathies caused by cholesterol insufficiency
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05/05/20Discovery of the mechanism through which RS virus infection induces bacterial pneumonia: Paving the way for the development of novel preventive and therapeutic methods to treat secondary bacterial pneumonia
Apr
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04/30/20Elucidation of a novel mechanism of exosome secretion in prostate cancer cells: Opening the way to novel prostate cancer therapies targeting exosomes
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04/29/20Lowered levels of a particular lipid in the brain of patients with schizophrenia: A new perspective for drug discovery
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04/27/20Establishment of a whole-organ/body imaging technique based on three-dimensional histology: An ideal protocol designed on the basis of physiochemical properties of biological tissues
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04/22/20Elucidation of the mechanism through which parasitic worms suppress autoimmune diseases: Shedding new light on the prevention and treatment of type 1 diabetes
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04/20/20Identification of calcium and integrin-binding protein 1 as a novel molecule involved in the early pathogenesis of Alzheimer's disease
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04/18/20Discovery of a new molecular mechanism determining messenger RNA stability: New machinery for monitoring the critical process of gene expression
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04/17/20Development of schizophrenia and autism classifiers based on brain functional connectivity, leading to elucidation of the relationship between the disorders: Opening the way for elucidation of the relationship between psychiatric disorders by disease classifiers adopting a machin...
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04/13/20Development of the web-based service “SANITA Mental Health Class,” which delivers mental health education resources compliant with the new Course of Study
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04/08/20Regeneration of renal tissue from multiple renal progenitor cells separately differentiated from human iPS cells
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04/07/20Prevention of dry eye disease with ω-hydroxy lipids in tear film - For the development of a new treatment for dry eye disease -
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04/07/20World's best performance in RNA analysis with single cells - Achievement in an international performance comparison study -
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04/06/20Safe thrombolytic therapy with alteplase for cerebral infarction of unknown onset time without the FLAIR imaging findings of cerebral infarction
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04/02/20First elucidation of the importance of the stomach in immune induction: discovery of the mechanism of immune protection by group 2 innate lymphoid cells against infection with Helicobacter pylori
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04/01/20Successful generation of disease model animals by target-specific gene switching
Mar
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03/31/20Tohoku Medical Megabank Organization and Japan Pharmaceutical Manufacturers Association launched a joint research project aiming at the early practical application of preventive/preemptive medical solutions
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03/31/20Discovery of new compounds involved in the circadian clock that also enhance brown adipocyte differentiation
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03/27/20Marketing approval of NS-065/NCNP-01 (“viltolarsen”) for the treatment of Duchenne muscular dystrophy
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03/26/20Elucidation of regional diversity in a Japanese population using machine learning for large-scale genomics - Utilization of Japanese genome data for genomic personalized medicine -
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03/25/20A new oncogenic function of the cell immortalizing enzyme telomerase - Development of a novel cancer treatment -
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03/25/20Publication of primate omics database, D3G, for drug discovery - Provision of high-quality data, including human and non-human primate genomes -
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03/25/20A new function of protein SLFN11 to markedly improve the efficacy of anticancer drugs
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03/24/20Reproduction of the forced termination of aberrant translational retardation in vitro - Mechanism of the fate determination of a nascent peptide chain by ribosome ubiquitination -
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03/24/20Hypertension and obesity were identified as major risk factors for shortening the life spans of today using genomic information collected from 700,000 people - Elucidation of health factors, treatable in all people, using inherent genetic information -
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03/23/20Identification of an existing Japanese pancreatitis drug, Nafamostat, as a candidate drug to prevent transmission of SARS-CoV-2
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03/23/20Involvement of the gene responsible for lysosomal disease in the development of Parkinson's disease - Possibility of a novel therapy targeting a lysosomal-related protein -
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03/19/20Identification of an intracellular signal critical for the development of head and neck cancer - Creation of a mouse model for the fastest cancer development -
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03/16/20Start of operation of a pathological diagnosis network and verification of an AI diagnosis system
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03/13/20Identification of the gene responsible for progressive myoclonic epilepsy
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03/12/20World's first prospective clinical test on a rare type of malignant lymphoma - Establishment of a standard treatment to improve the prognosis of patients -
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03/07/20Establishment of a foundation for the simulation experiment of bone reconstruction (remodeling) - To predict the effects of drug therapy on bone diseases -
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03/06/20Elucidation of the mechanism of psychosomatic correlation connecting the mind and body - A new treatment strategy for stress-related diseases -
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03/06/20Characterization of mitochondria carrying unique genomes in a Japanese population
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03/06/20Elucidation of the genetic mechanism of efficient DNA damage repair - Revelation of the pathogenesis of Cockayne syndrome (progeria), a rare hereditary intractable disease/Establishment of a disease mouse model useful for elucidating the pathological conditions of various aging-r...
Feb
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02/28/20Dietary fiber intake during pregnancy promotes the development of metabolic functions in fetuses to render the offspring resistant to obesity after birth
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02/27/20Development of engineered immune cells sensing pathogenic virus with high sensitivity to prevent infection
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02/26/20Discovery of novel treatment target and predictive markers of postoperative prognosis for lung cancer frequently observed in the Japanese (lung adenocarcinoma)
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02/26/20Elucidation of the molecular mechanism of the gene mutation responsible for impairing brain development and sociality in autism spectrum disorder patients―expectation of development of a therapeutic strategy for the disorder―
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02/25/20Regulatory approval for ALK inhibitor alectinib for recurrent/refractory ALK-positive anaplastic large cell lymphoma
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02/25/20Brain system involved in concern over others’ gain: neuronal mechanism to process and integrate information on reward obtained by self and others
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02/24/20Postulated action mechanism of anti-PD-1 antibody for Hodgkin Lymphoma - Transfer of PD-L1/L2 from cancer cells to cancer-supporting monocytes/macrophages through trogocytosis -
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02/20/20World’s first success in elucidating the molecular mechanism of action for the anti-inflammatory effects of sesamin
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02/19/20Important roles of the synapses in spinal and bulbar muscular atrophy - Elucidation of pathology and development of therapies by targeting neuromuscular junctions -
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02/19/20Elucidation of the mechanism of impaired predictability of the brain in schizophrenia
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02/07/20Determining the risk of Parkinson’s disease and dementia during annual checkups―A step forward in prevention and early detection
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02/06/20Results from a research on the prognosis of Leigh syndrome in Japan
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02/06/20Proposal of measures for controlling Zika fever in its endemic areas based on survey results of the Zika virus epidemic in Vietnam
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02/06/20Identification of a nuclear proteolytic mechanism induced by liquid–liquid phase separation: A novel proteolytic mechanism that helps cells to adapt to environmental stress
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02/06/20Semaphorin is a key molecule that induces the formation of nasal polyps: A novel diagnostic and treatment target for refractory empyema
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02/04/20Mechanoreceptor regulates cold tolerance: A novel insight into the mechanism of temperature sensing
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02/04/20Establishment of a genetic risk score model for ischemic stroke: Validation in a prospective cohort in the “Hisayama Study”
Jan
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01/30/20Proposal of measures for controlling Zika fever in its endemic areas based on survey results of the Zika virus epidemic in Vietnam
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01/29/20Approval of deep learning-based software (EndoBRAIN®-EYE) as a medical device to support endoscopic image diagnosis
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01/28/20Risk factors for severe drug eruption caused by sulfa drugs - Prevention of adverse effects by genetic testing -
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01/27/20Investigator-initiated clinical trial of cardiomyocyte sheets generated from iPS cells -Treatment of severe cardiomyopathy -
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01/27/20Visual restoration by innovative gene therapy using genome editing technologies – toward realization of Gene therapy to normalize gene mutations -
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01/24/20Repair of articular cartilage damage by transplantation of allogeneic iPS cell-derived cartilage
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01/24/20Viral encephalitis caused by autophagy suppression - New findings of the pathogenesis of the West Nile virus -
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01/23/20How to keep boron inside cells during radiotherapy: a simple novel approach to cancer treatment
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01/21/20Development of an artificial protein to cure intractable wounds - Implementation of a company-initiated clinical trial after an investigator-initiated clinical trial through industry-government-academia collaboration -
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01/21/20Elucidation of the lipid production mechanism critical for skin barrier formation - Drug development for skin barrier-related diseases -
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01/21/20Visualization of the AMPA receptor responsible for brain functions in the living human brain
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01/20/20Identification of gene regions and traits responsible for adaptive evolution in Japanese and Westerners - Alcohol and bread intakes are deeply involved in Japanese and Westerners, respectively
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01/17/20Elucidation of intestinal environment changes due to gastrectomy - Overcoming complications after gastrectomy
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01/15/20Development of an educational support program for the family members of “hikikomori” (socially withdrawn) people - Advances in addressing long-term social withdrawal -
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01/14/20Novel immunoregulation method with iPS cells - Utilization of iPS cells in transplantation medicine
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01/10/20Increased BACH1 protein function serves as a switch that promotes pancreatic cancer metastasis.
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01/08/20Generating functional hypothalamic-pituitary units from human iPS cells: Contribution to regenerative medicine and disease study
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01/07/20Discovery of the key to pathogenetic mechanism underlying “Severe Fever with Thrombocytopenia Syndrome (SFTS)”, a tick-borne viral infectious disease: Identification of viral infection target cells
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01/06/20Development of a monitoring method for tumorigenicity following iPS cells transplantation: Visualization of tumorigenic changes of neural stem/progenitor cells