News Releases & Research Results News Releases & Research Results（2020）
Oct
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2020.10.16Neural circuits responsible for monitoring others’ actions
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2020.10.14Prostaglandin pathway associated with lifestyle-related diseases - Efficacy of aspirin and EP4 antagonist as antimetabolite drug candidates -
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2020.10.13Energy dynamic imaging for living kidneys - Renal prognosis based on the energy metabolism of the proximal tubules -
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2020.10.12A novel mechanism involved in the pathophysiology of autism spectrum disorder - Promote the establishment of therapeutic strategies and the development of new drugs for autism spectrum disorder -
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2020.10.9T cell abnormality characteristic of severe COVID-19
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2020.10.6Genome-wide association studies in more than 600,000 individuals reveal the effect of variants on the onset of coronary artery disease
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2020.10.6Development of Precision Medicine for Gastrointestinal Cancers: Utility of Liquid Biopsy in Genomic Analysis
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2020.10.2A highly accurate method for genome sequence estimation with privacy protection ensured - A novel deep learning-based method -
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2020.10.1Personality classification enhances the discrimination capacity of a blood biomarker for depression - Human-mouse cross-validation study -
Sep
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2020.9.30Mechanism of Salmonella infectious prevention mediated by short-chain fatty acid binding to a novel receptor protein
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2020.9.30Mechanism of gastritis caused by Helicobacter pylori: paving the way for the development of therapeutic modalities other than antibiotic eradication of H. pylori
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2020.9.29Development of a novel method for decoding viral genomes: discovery of novel viral proteins and elucidation of the pathogenesis of viral encephalitis
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2020.9.29Novel treatment for patients with heart failure: the effectiveness of cardiac rehabilitation
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2020.9.28The successful identification and characterization of in vivo senescent cells
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2020.9.28Suppression of the development of hepatocellular carcinoma by selective removal of damaged mitochondria: A rationale for a novel drug discovery strategy targeting dysfunctional mitochondria
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2020.9.17Transplantation of CD73-positive cells suppresses pulmonary fibrosis paving the way to the development of a novel therapy through induction of immune tolerance
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2020.9.17Depression-related PCSK5 gene, which induces inflammation in the deep brain, discovered in a mouse experiment
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2020.9.16Discovery of the molecular and neural mechanisms involved in the refractory manifestations of schizophrenia: Elucidation of a novel function of the schizophrenia-related gene SETD1A
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2020.9.15Development and validation of new diagnostic criteria for allergic bronchopulmonary mycosis
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2020.9.14Elucidation of the mechanism by which the effects of immunomodulator thalidomide on target proteins are altered through metabolism in the body - Development of drugs with few side effects -
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2020.9.14Lipid metabolism disorder in the cerebral white matter of schizophrenia patients - Unknown pathogenesis of schizophrenia -
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2020.9.11New findings of Japanese women’s menstrual cycle and basal body temperature by big data analysis – Age-dependent significant changes in menstrual cycle and basal body temperature during the high-temperature phase -
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2020.9.11Elucidation of the mechanism by which the foreign DNA sensor cGAS for innate immunity does not respond to autologous chromosomal DNA - A clue to elucidating the causes of diseases such as viral infection protection, autoimmune diseases, cancer, and neurodegenerative diseases -
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2020.9.11Discovery of a candidate biomarker for autism spectrum disorder - Biological reclassification of autism spectrum disorder -
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2020.9.8Development of a method for selectively removing undifferentiated iPS cells with an anti-obesity drug - Accelerating the realization of regenerative medicine with reduced risks of formation -
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2020.9.4Membrane protein PGRMC1 promotes obesity by facilitating lipid accumulation
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2020.9.4Activation of muscle stem cells by damaged muscles: Clues for elucidation of the pathogenesis of muscle diseases and the development of drugs for their treatment
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2020.9.3Novel circular RNA highly expressed in pancreatic cancer and its application as a biomarker: development of a novel diagnostic marker for pancreatic cancer
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2020.9.2Controlling the actions and physical properties of drugs by metal-catalyzed reactions in vivo: a new direction in designing prodrugs
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2020.9.2Discovery of a novel model of neural circuitry in basal ganglia involved in motor control: Interaction between direct and indirect pathways
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2020.9.1High-precision biomarker predictive of clinical efficacy of immune checkpoint inhibitors (PD-1/PD-L1 inhibitors): precision medicine in immunotherapy
Aug
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2020.8.28Extracellular vesicles secreted by HBV-infected cells prevent elimination of HBV in a mouse model of HBV infection.
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2020.8.28Efficient induction of cardiomyocytes using a soft scaffold for establishment of a new method for cardiac regeneration
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2020.8.27Elucidation of mechanism of central nervous inflammation promoted by gut microorganisms - a novel potential treatment and prevention method for multiple sclerosis
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2020.8.25Dysbiosis in the Gut Microbiome Shapes Disease Course in the Different Stages of Multiple Sclerosis - Combination of microbial composition and comprehensive functional gene analyses revealed the key microbial function associated with secondary progressive multiple sclerosis -
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2020.8.25Fibroblasts prevent auto-immunity - discovery of novel mechanism of T cell training -
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2020.8.21Sex difference in the mechanism of skeletal muscle growth and regeneration - elucidation of functional significance of estrogen receptor β
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2020.8.20How does aging cause lifestyle-related diseases? - A novel treatment strategy using autophagy inhibition -
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2020.8.20Discovery of a novel mutation involved in the progression of childhood brain tumor: A strategic foundation for personalized treatment for various cancers based on cell type
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2020.8.18Unveiling the DNA-binding mechanism of the transcription factor GATA3 which controls cell fate: A clue to elucidate etiologies of breast cancer and other diseases
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2020.8.17Development of a method to distinguish between schizophrenia and developmental disorder based on a machine-learning classification using neuroimaging data
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2020.8.17Elucidation of the chronic mechanisms of acute kidney injury using Mincle, a sensor for cell death - Development of novel preventive methods for chronic kidney diseases -
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2020.8.17Prediction of the risks of depressive symptoms using machine learning - For personalized medicine for mental disorders -
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2020.8.14Reinforcement of the pain control system in the brain through simultaneous learning by the brain and AI agents
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2020.8.11Development of a novel transplantation model for regenerative medicine - To promote iPS cell-based transplantation medicine -
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2020.8.11Identification of potential susceptibility genes for Japanese familial pancreatic cancer - To overcome pancreatic cancer -
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2020.8.7Discovery of a common mechanism underlying onset of a group of dementias called the frontotemporal lobar degeneration spectrum diseases
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2020.8.7Unbalanced neuronal fate specification associated with psychoses: Insights from research on brain organoids derived from induced pluripotent stem cells
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2020.8.5A molecular mechanism underlying the induction of direct hepatic reprogramming: Discovery of a novel mechanism of action of transcription factors
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2020.8.1Identification of a risk locus for interstitial lung disease complicating rheumatoid arthritis, as well as its association with chest CT image patterns related to pulmonary fibrosis
Jul
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2020.7.31Development of a method to elucidate complex genomic rearrangements using a new technology, long-read sequencer
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2020.7.31Are viruses active indoors or outdoors? - Elucidation of the strategy of hepatitis C virus infection in an integrated study of mathematics and experiments -
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2020.7.30Association of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages - Elucidation of a biological characteristic of supercentenarians -
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2020.7.29Elucidation of the molecular onset mechanism of incurable COPA syndrome - Development of new therapeutic agents for autoimmune/autoinflammatory diseases -
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2020.7.29Production of a large amount of tissue that serves as a source of the renal collecting duct
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2020.7.24Elucidation of clinical and genetic characteristics of mitochondrial liver disease for the first time in Japanese
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2020.7.23Optical biopsy for the immediate diagnosis of cancer without excision - Stereoscopic observation without tissue damage by imaging, followed by AI-based automatic diagnosis -
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2020.7.22Identification of a gene mutation strongly associated with the onset of schizophrenia by genome analysis!
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2020.7.22Unknown effects of intestinal flora on the spread of systemic inflammation
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2020.7.17Relief of phantom pain in hands lost in accidents by training to change brain activities - Novel treatment by a technology to move phantom limbs using brain signals -
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2020.7.15Multiomics analysis of HIV-1-infected cells in vivo - Clues for the development of an HIV-1 cure -
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2020.7.11Elucidation of the mechanism of cancer progression induced by a factor from vascular endothelial cells in tumor tissues - Development of novel therapies targeting the signals of cancer microenvironment networks -
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2020.7.10Development of a novel antibody drug for canine lymphoma - Starting a veterinarian-initiated clinical trial on canine lymphoma -
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2020.7.10Large-scale international analysis on the causative gene of severe cardiomyopathy in newborns - Early diagnosis and development of therapies of cardiomyopathy -
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2020.7.8Treatment of malignant tumors by “poison control by poisoning” - A novel therapeutic strategy for refractory tumors by reverse thinking -
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2020.7.8A cyclic peptide that enhances the anticancer effects of antibody drugs
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2020.7.7Development of a drug candidate that specifically acts on a “switch” in the brain - Fast-acting therapy without any side effects for psychiatric and neurological diseases -
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2020.7.3Effectiveness of transplantation of skeletal muscle stem cells derived from human induced pluripotent stem cells in muscular dystrophy mouse model
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2020.7.3Discovery of the structural change of norovirus particles before infection: A significant advance in the elucidation of the mechanism underlying norovirus infection, which should facilitate the development of novel therapeutic drugs and vaccines
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2020.7.1Discovery of a new mode of signal transmission in the brain - Clues for the development and treatment of diseases -
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2020.7.1In vivo visualization of an abnormal protein potentially inducing depression in older individuals: opening a path for the treatment and prevention of depression in the elderly
Jun
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2020.6.30Identification of a novel protein that prevents the development of autoimmune diseases - The chromatin remodeling factor Chd4 plays a role in self-antigen expression and prevents autoimmune diseases -
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2020.6.30Nationwide Survey of Chronic Active EB Virus Infection Based on the New WHO Classification and the New Diagnostic Criteria - Unravelling the Differences between Childhood and Elderly Onset Cases and their Treatments -
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2020.6.26Optical manipulation of neurons successfully evoking forelimb movements in monkeys
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2020.6.26Launch of an investigator-initiated clinical trial of a medical robot for needle insertion (Zerobot®) developed at Okayama University
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2020.6.26Discovery of a new autoantibody as an important cause of recurrent pregnancy loss
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2020.6.25To elucidate leukemia development mechanisms particular to the Japanese - Results of utilizing the BioBank Japan database -
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2020.6.25New SATREPS Projects for FY 2020 under AMED International Collaborative Research Program
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2020.6.24Discovery of specific functions of DNA methyltransferases, DNMT3A and DNMT3B - Contributing to the elucidation of mammalian development and cancer development mechanisms -
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2020.6.23Elucidation of the pathology of the novel coronavirus (SARS-CoV-2) infection (COVID-19) / Development of prevention and treatment methods - Usefulness of Syrian hamsters as an animal model for infection
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2020.6.19Altered DNA methylation status of a serotonin-related gene in male patients with schizophrenia and bipolar disorder
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2020.6.17Discovery of novel genes responsible for developmental disorders with trigonocephaly - New findings leading to the elucidation of the onset mechanism of developmental disorders -
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2020.6.12Elucidation of a novel anti-inflammatory mechanism created by the autonomic nervous system - New treatment for vagal infection, cancer, and inflammatory bowel diseases -
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2020.6.10Development of gene-targeted antibacterial drugs for selective killing of bacteria - To overcome drug-resistant bacteria -
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2020.6.10Launch of CIRCULATE-Japan, a new project for personalized cancer treatment by liquid biopsy - Launch of the world’s largest investigator-initiated international joint trial on invisible cancers -
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2020.6.9Elucidation of genetic characteristics associated with disease onset in Japanese people: Genetic mutation screening by genome analysis in 210,000 Japanese individuals
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2020.6.5Discovery of a key molecule regulating sperm maturation: A new perspective on the etiology and treatment of infertility
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2020.6.4Comprehensive description of the human tissue virome in healthy individuals - “Hidden” associations between the human virome and human health and disease -
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2020.6.3Development of a novel therapy for Alport syndrome using an oligonucleotide therapeutic: Remarkable effectiveness confirmed in model animal for refractory inherited kidney disease
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2020.6.2Development of a sperm sorting technique that improves the success rate of in vitro fertilization
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2020.6.1Elucidation of a novel mechanism underlying inflammatory and malignant diseases caused by human T cell leukemia virus type 1, which is common among the Japanese population
May
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2020.5.27Novel drug candidate for polyglutamine (polyQ) diseases, intractable neurodegenerative diseases – Protein structure-stabilizing effects of L-arginine against aggregation
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2020.5.22Development of a new functional analysis method for BRCA2 gene variants that increase the risk of hereditary breast and ovarian cancers
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2020.5.21Molecular design of Smart Nanomachine® for treating Alzheimer's dementia with a low dose of antibody drug
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2020.5.21Fluorescence technology to visualize mitochondrial mitophagy - Contribution to the diagnosis and treatment of Parkinson's disease -
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2020.5.21Clinical trial with human ES cells for congenital urea cycle disorder - World's first transplantation of human ES cell-derived hepatocytes into humans!
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2020.5.12Identification of new gene regions responsible for type 2 diabetes in an East Asian population
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2020.5.7Genetic backgrounds and lifestyle habits predisposing the Japanese population to gastric cancer: Results of a large-scale trans-ethnic genome analysis in patients with gastric cancer
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2020.5.6Discovery of a new metabolic enzyme that mobilizes health-beneficial omega-3 fatty acids and suppresses obesity
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2020.5.5Discovery of a new function of peroxisomes as suppliers of cholesterol to cilia: Elucidation of the mechanism of the onset of ciliopathies caused by cholesterol insufficiency
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2020.5.5Discovery of the mechanism through which RS virus infection induces bacterial pneumonia: Paving the way for the development of novel preventive and therapeutic methods to treat secondary bacterial pneumonia
Apr
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2020.4.30Elucidation of a novel mechanism of exosome secretion in prostate cancer cells: Opening the way to novel prostate cancer therapies targeting exosomes
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2020.4.29Lowered levels of a particular lipid in the brain of patients with schizophrenia: A new perspective for drug discovery
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2020.4.27Establishment of a whole-organ/body imaging technique based on three-dimensional histology: An ideal protocol designed on the basis of physiochemical properties of biological tissues
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2020.4.22Elucidation of the mechanism through which parasitic worms suppress autoimmune diseases: Shedding new light on the prevention and treatment of type 1 diabetes
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2020.4.20Identification of calcium and integrin-binding protein 1 as a novel molecule involved in the early pathogenesis of Alzheimer's disease
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2020.4.18Discovery of a new molecular mechanism determining messenger RNA stability: New machinery for monitoring the critical process of gene expression
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2020.4.17Development of schizophrenia and autism classifiers based on brain functional connectivity, leading to elucidation of the relationship between the disorders: Opening the way for elucidation of the relationship between psychiatric disorders by disease classifiers adopting a machin...
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2020.4.13Development of the web-based service “SANITA Mental Health Class,” which delivers mental health education resources compliant with the new Course of Study
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2020.4.8Regeneration of renal tissue from multiple renal progenitor cells separately differentiated from human iPS cells
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2020.4.7Prevention of dry eye disease with ω-hydroxy lipids in tear film - For the development of a new treatment for dry eye disease -
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2020.4.7World's best performance in RNA analysis with single cells - Achievement in an international performance comparison study -
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2020.4.6Safe thrombolytic therapy with alteplase for cerebral infarction of unknown onset time without the FLAIR imaging findings of cerebral infarction
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2020.4.2First elucidation of the importance of the stomach in immune induction: discovery of the mechanism of immune protection by group 2 innate lymphoid cells against infection with Helicobacter pylori
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2020.4.1Successful generation of disease model animals by target-specific gene switching
Mar
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2020.3.31Tohoku Medical Megabank Organization and Japan Pharmaceutical Manufacturers Association launched a joint research project aiming at the early practical application of preventive/preemptive medical solutions
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2020.3.31Discovery of new compounds involved in the circadian clock that also enhance brown adipocyte differentiation
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2020.3.27Marketing approval of NS-065/NCNP-01 (“viltolarsen”) for the treatment of Duchenne muscular dystrophy
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2020.3.26Elucidation of regional diversity in a Japanese population using machine learning for large-scale genomics - Utilization of Japanese genome data for genomic personalized medicine -
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2020.3.25A new oncogenic function of the cell immortalizing enzyme telomerase - Development of a novel cancer treatment -
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2020.3.25Publication of primate omics database, D3G, for drug discovery - Provision of high-quality data, including human and non-human primate genomes -
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2020.3.25A new function of protein SLFN11 to markedly improve the efficacy of anticancer drugs
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2020.3.24Reproduction of the forced termination of aberrant translational retardation in vitro - Mechanism of the fate determination of a nascent peptide chain by ribosome ubiquitination -
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2020.3.24Hypertension and obesity were identified as major risk factors for shortening the life spans of today using genomic information collected from 700,000 people - Elucidation of health factors, treatable in all people, using inherent genetic information -
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2020.3.23Identification of an existing Japanese pancreatitis drug, Nafamostat, as a candidate drug to prevent transmission of SARS-CoV-2
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2020.3.23Involvement of the gene responsible for lysosomal disease in the development of Parkinson's disease - Possibility of a novel therapy targeting a lysosomal-related protein -
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2020.3.19Identification of an intracellular signal critical for the development of head and neck cancer - Creation of a mouse model for the fastest cancer development -
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2020.3.16Start of operation of a pathological diagnosis network and verification of an AI diagnosis system
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2020.3.13Identification of the gene responsible for progressive myoclonic epilepsy
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2020.3.12World's first prospective clinical test on a rare type of malignant lymphoma - Establishment of a standard treatment to improve the prognosis of patients -
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2020.3.7Establishment of a foundation for the simulation experiment of bone reconstruction (remodeling) - To predict the effects of drug therapy on bone diseases -
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2020.3.6Elucidation of the mechanism of psychosomatic correlation connecting the mind and body - A new treatment strategy for stress-related diseases -
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2020.3.6Characterization of mitochondria carrying unique genomes in a Japanese population
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2020.3.6Elucidation of the genetic mechanism of efficient DNA damage repair - Revelation of the pathogenesis of Cockayne syndrome (progeria), a rare hereditary intractable disease/Establishment of a disease mouse model useful for elucidating the pathological conditions of various aging-r...
Feb
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2020.2.28Dietary fiber intake during pregnancy promotes the development of metabolic functions in fetuses to render the offspring resistant to obesity after birth
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2020.2.27Development of engineered immune cells sensing pathogenic virus with high sensitivity to prevent infection
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2020.2.26Discovery of novel treatment target and predictive markers of postoperative prognosis for lung cancer frequently observed in the Japanese (lung adenocarcinoma)
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2020.2.26Elucidation of the molecular mechanism of the gene mutation responsible for impairing brain development and sociality in autism spectrum disorder patients―expectation of development of a therapeutic strategy for the disorder―
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2020.2.25Regulatory approval for ALK inhibitor alectinib for recurrent/refractory ALK-positive anaplastic large cell lymphoma
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2020.2.25Brain system involved in concern over others’ gain: neuronal mechanism to process and integrate information on reward obtained by self and others
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2020.2.24Postulated action mechanism of anti-PD-1 antibody for Hodgkin Lymphoma - Transfer of PD-L1/L2 from cancer cells to cancer-supporting monocytes/macrophages through trogocytosis -
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2020.2.20World’s first success in elucidating the molecular mechanism of action for the anti-inflammatory effects of sesamin
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2020.2.19Important roles of the synapses in spinal and bulbar muscular atrophy - Elucidation of pathology and development of therapies by targeting neuromuscular junctions -
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2020.2.19Elucidation of the mechanism of impaired predictability of the brain in schizophrenia
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2020.2.7Determining the risk of Parkinson’s disease and dementia during annual checkups―A step forward in prevention and early detection
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2020.2.6Results from a research on the prognosis of Leigh syndrome in Japan
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2020.2.6Proposal of measures for controlling Zika fever in its endemic areas based on survey results of the Zika virus epidemic in Vietnam
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2020.2.6Identification of a nuclear proteolytic mechanism induced by liquid–liquid phase separation: A novel proteolytic mechanism that helps cells to adapt to environmental stress
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2020.2.6Semaphorin is a key molecule that induces the formation of nasal polyps: A novel diagnostic and treatment target for refractory empyema
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2020.2.4Mechanoreceptor regulates cold tolerance: A novel insight into the mechanism of temperature sensing
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2020.2.4Establishment of a genetic risk score model for ischemic stroke: Validation in a prospective cohort in the “Hisayama Study”
Jan
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2020.1.30Proposal of measures for controlling Zika fever in its endemic areas based on survey results of the Zika virus epidemic in Vietnam
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2020.1.29Approval of deep learning-based software (EndoBRAIN®-EYE) as a medical device to support endoscopic image diagnosis
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2020.1.28Risk factors for severe drug eruption caused by sulfa drugs - Prevention of adverse effects by genetic testing -
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2020.1.27Investigator-initiated clinical trial of cardiomyocyte sheets generated from iPS cells -Treatment of severe cardiomyopathy -
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2020.1.27Visual restoration by innovative gene therapy using genome editing technologies – toward realization of Gene therapy to normalize gene mutations -
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2020.1.24Repair of articular cartilage damage by transplantation of allogeneic iPS cell-derived cartilage
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2020.1.24Viral encephalitis caused by autophagy suppression - New findings of the pathogenesis of the West Nile virus -
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2020.1.23How to keep boron inside cells during radiotherapy: a simple novel approach to cancer treatment
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2020.1.21Development of an artificial protein to cure intractable wounds - Implementation of a company-initiated clinical trial after an investigator-initiated clinical trial through industry-government-academia collaboration -
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2020.1.21Elucidation of the lipid production mechanism critical for skin barrier formation - Drug development for skin barrier-related diseases -
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2020.1.21Visualization of the AMPA receptor responsible for brain functions in the living human brain
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2020.1.20Identification of gene regions and traits responsible for adaptive evolution in Japanese and Westerners - Alcohol and bread intakes are deeply involved in Japanese and Westerners, respectively
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2020.1.17Elucidation of intestinal environment changes due to gastrectomy - Overcoming complications after gastrectomy
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2020.1.15Development of an educational support program for the family members of “hikikomori” (socially withdrawn) people - Advances in addressing long-term social withdrawal -
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2020.1.14Novel immunoregulation method with iPS cells - Utilization of iPS cells in transplantation medicine
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2020.1.10Increased BACH1 protein function serves as a switch that promotes pancreatic cancer metastasis.
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2020.1.8Generating functional hypothalamic-pituitary units from human iPS cells: Contribution to regenerative medicine and disease study
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2020.1.7Discovery of the key to pathogenetic mechanism underlying “Severe Fever with Thrombocytopenia Syndrome (SFTS)”, a tick-borne viral infectious disease: Identification of viral infection target cells
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2020.1.6Development of a monitoring method for tumorigenicity following iPS cells transplantation: Visualization of tumorigenic changes of neural stem/progenitor cells